Gene therapy through signal transduction pathways and angiogenic growth factors as therapeutic targets in breast cancer

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

Isolation and structure of bryostatin 1

1982 • 638 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Microvessel quantitation and prognosis in invasive breast carcinoma

1992 • 566 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections.

1990 • 428 citations

Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response

1987 • 416 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

Karnofsky Memorial Lecture. The immunotherapy and gene therapy of cancer.

1992 • 394 citations

Suramin: an anticancer drug with a unique mechanism of action.

1989 • 370 citations

Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages.

1984 • 366 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTORS ASSOCIATED WITH LACK OF RESPONSE TO ENDOCRINE THERAPY IN RECURRENT BREAST CANCER

1989 • 224 citations

In vitro and in vivo targeting of gene expression to melanoma cells.

1993 • 190 citations

Epidermal growth factor receptor (EGFr); results of a 6 year follow-up study in operable breast cancer with emphasis on the node negative subgroup

1991 • 171 citations

Novel growth regulatory factors and tumour angiogenesis

1991 • 162 citations

Quantitative in-vivo studies on angiogenesis in a rat sponge model.

1987 • 143 citations

The mitogenic signaling pathway but not the plasminogen activator-inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells.

1989 • 133 citations

Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites.

1991 • 115 citations

Vasculature as a Target for Tumour Therapy

2015 • 109 citations

Tumor Growth Dependent on Kaposi's Sarcoma-Derived Fibroblast Growth Factor Inhibited by Pentosan Polysulfate

1991 • 106 citations

Suramin: prototype of a new generation of antitumor compounds.

1990 • 101 citations

Epidermal growth factor receptor and other oncogenes as prognostic markers.

1992 • 98 citations

Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells.

1986 • 98 citations

Protein kinase C activators suppress stimulation of capillary endothelial cell growth by angiogenic endothelial mitogens.

1987 • 97 citations

Successful treatment of murine melanoma with bryostatin 1.

1991 • 94 citations

Heparin-binding growth factor 1 stimulates tyrosine phosphorylation in NIH 3T3 cells.

1989 • 85 citations

Monoclonal antibodies directed against basic fibroblast growth factor which inhibit its biological activity in vitro and in vivo

1989 • 72 citations

Anticancer strategies involving the vasculature: vascular targeting and the inhibition of angiogenesis.

1992 • 65 citations

Loss of HLA class‐I alleles, heavy chains and β₂‐microglobulin in colorectal cancer

1992 • 61 citations

Gene expression and immunohistochemical localization of basic fibroblast growth factor in renal cell carcinoma

1992 • 52 citations

Bifunctional effects of transforming growth factor-β (TGF-β) on endothelial cell growth correlate with phenotypes of TGF-β binding sites

1990 • 51 citations

Angiogenic effects of macrophages isolated from ascitic fluid aspirated from women with advanced ovarian cancer

1992 • 48 citations

Localization of platelet-derived endothelial cell growth factor in human placenta and purification of an alternatively processed form.

1990 • 44 citations

Phorbol ester and bryostatin effects on growth and the expression of oestrogen responsive and TGF-β1 genes in breast tumour cells

1991 • 28 citations

Growth control of normal and malignant breast epithelium.

1990 • 26 citations

Mast cell-basophil system in tumor growth.

1989 • 7 citations

The Therapeutic Implications of the Molecular Biology of Breast Cancer

1991 • 6 citations

PROGNOSTIC-SIGNIFICANCE OF C-ERBB-2 ONCOPROTEIN EXPRESSION IN BREAST-CANCER - AN IMMUNOHISTOCHEMICAL STUDY

1988 • 1 citations