The psychopharmacology of the human pineal

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Light Suppresses Melatonin Secretion in Humans

1980 • 1,873 citations

Proceedings of the National Academy of Sciences, USA

1996 • 1,621 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

The British Journal of Psychiatry

2005 • 976 citations

Molecular Pharmacology

1971 • 853 citations

Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N -Acetyltransferase

1970 • 748 citations

Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus

1979 • 582 citations

The development, topographical relations and innervation of the epiphysis cerebri in the albino rat

1960 • 566 citations

Mode of action of antidepressant drugs

1978 • 514 citations

Retinohypothalamic projection in mammals: a comparative study

1973 • 475 citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

1985 • 415 citations

Age-Dependent Reduction in Serum Melatonin Concentrations in Healthy Human Subjects

1982 • 379 citations

Photoneural Regulation of the Mammalian Pineal Gland

1985 • 367 citations

Rapid Light-Induced Decrease in Pineal Serotonin N -Acetyltransferase Activity

1972 • 356 citations

Biological Psychiatry

1985 • 337 citations

FALL IN NOCTURNAL SERUM MELATONIN DURING PREPUBERTY AND PUBESCENCE

1984 • 309 citations

A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression.

1984 • 295 citations

Supersensitivity to light: possible trait marker for manic-depressive illness

1985 • 276 citations

Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase.

1983 • 263 citations

Melatonin Metabolism: Neural Regulation of Pineal Serotonin: Acetyl Coenzyme A N -Acetyltransferase Activity

1971 • 261 citations

Atypical Synergisticα₁- andβ-Adrenergic Regulation of Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′- Monophosphate in Rat Pinealocytes

1985 • 256 citations

European Journal of Pharmacology

2004 • 253 citations

Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects

1985 • 247 citations

Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic→ spinal cord circuit in the melatonin rhythm generating system

1983 • 236 citations

Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects

1984 • 233 citations

Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome

1985 • 222 citations

Different Types of Melatonin Circadian Secretory Rhythms in Some Blind Subjects

1983 • 214 citations

Nocturnal Elevation of Plasma Melatonin and Urinary 5-Hydroxyindoleacetic Acid in Young Men: Attempts at Modification by Brief Changes in Environmental Lighting and Sleep and by Autonomic Drugs

1976 • 201 citations

Substance P containing and cholinergic projections from the habenula

1978 • 194 citations

HUMAN SERUM MELATONIN CHANGES DURING THE MENSTRUAL CYCLE

1976 • 181 citations

Two-oscillator structure of the pacemaker controlling the circadian rhythm of N-acetyltransferase in the rat pineal gland

1982 • 177 citations

CONTROL OF THE CIRCADIAN RHYTHM IN SEROTONIN CONTENT OF THE RAT PINEAL GLAND

1965 • 170 citations

Melatonin, the pineal gland and human puberty

1979 • 166 citations

Regulation of Pineal Melatonin in the Syrian Hamster

1979 • 165 citations

PINEALECTOMY ABOLISHES PLASMA MELATONIN IN THE RAT

1980 • 161 citations

Regional Distribution of Prostaglandins D₂, E₂, and F_2α and Related Enzymes in Postmortem Human Brain

1984 • 148 citations

Effects of damage to the suprachiasmatic area of the anterior hypothalamus on the daily melatonin and cortisol rhythms in the rhesus monkey

1981 • 146 citations

Beta adrenergic-blockers decrease adrenergically stimulated N-acetyltransferase activity in pineal glands in organ culture

1976 • 145 citations

Evidence for a specific monoamine oxidase associated with sympathetic nerves

1971 • 142 citations

Plasma melatonin—An index of brain aging in humans?

1986 • 136 citations

The Circadian Pattern of Melatonin and Its Positive Relationship with Progesterone in Women

1986 • 136 citations

A Comparison of Melatonin Secretion in Depressed Patients and Normal Subjects

1988 • 135 citations

THE EFFECTS OF EXOGENOUS MELATONIN ON ENDOCRINE FUNCTION IN MAN

1986 • 133 citations

Role of the pineal gland and melatonin in seasonal reproductive function in mammals.

1986 • 131 citations

Some Effects of Melatonin and the Control of its Secretion in Humans

1985 • 130 citations

Sympathetic Nerve Endings in the Pineal Gland Protect Against Acute Stress-Induced Increase in N-Acetyltransferase (EC 2.3.1.5.) Activity

1976 • 127 citations

Patterns of plasma melatonin with ageing and mental condition: stability of nyctohemeral rhythms and differences in seasonal variations

1984 • 123 citations

REDUCED NOCTURNAL MELATONIN SECRETION IN CHRONIC SCHIZOPHRENIA: RELATIONSHIP TO BODY WEIGHT

1982 • 120 citations

A Melatonin Rhythm Persists in Rat Pineals in Darkness1

1971 • 117 citations

Intraventricular Carbachol Mimics the Effects of Light on the Circadian Rhythm in the Rat Pineal Gland

1979 • 115 citations

The circadian rhythm in plasma melatonin concentration of the urbanized man: the effect of summer and winter time

1985 • 114 citations

The relationship between the pineal gland and the pituitary-adrenal axis in health, endocrine and psychiatric conditions

1983 • 109 citations

Effect of Norepinephrine on the Concentration of Adenosine 3′,5′-Monophosphate of Rat Pineal Gland in Organ Culture

1972 • 109 citations

Circadian Rhythms in Serum Melatonin from Infancy to Adolescence

1985 • 109 citations

Role of the beta adrenergic receptor in the elevation of adenosine cyclic 3',5'-monophosphate and induction of serotonin N-acetyltransferase in rat pineal glands.

1973 • 107 citations

ABNORMAL CIRCADIAN RHYTHM OF MELATONIN IN DIABETIC AUTONOMIC NEUROPATHY

1986 • 104 citations

MEDIATION BY β‐ADRENERGIC RECEPTORS OF EFFECT OF NOREPINEPHRINE ON PINEAL SYNTHESIS OF [¹⁴C]SEROTONIN AND [¹⁴C]MELATONIN

1971 • 101 citations

Reciprocal Day/Night Relationship between Serotonin Oxidation and N-Acetylation Products in the Rat Pineal Gland^*

1983 • 95 citations

A clinical study on the relationship between the pineal gland and the opioid system

1986 • 94 citations

Vasoactive Intestinal Peptide Stimulation of Pineal Serotonin-N-Acetyltransferase Activity: General Characteristics

1983 • 88 citations

Atenolol reduces plasma melatonin concentration in man.

1983 • 87 citations

24‐HOUR PROFILES OF MELATONIN, CORTISOL, INSULIN, C‐PEPTIDE AND GIP FOLLOWING A MEAL AND SUBSEQUENT FASTING

1982 • 87 citations

Cyclic Adenosine Monophosphate: Stimulation of Melatonin and Serotonin Synthesis in Cultured Rat Pineals

1969 • 85 citations

Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase.

1976 • 84 citations

Effect of treatment of rats with antidepressants on melatonin concentrations in the pineal gland and serum.

1982 • 83 citations

Postsynaptic localization of the alpha receptor-mediated stimulation of phosphatidylinositol turnover in pineal gland

1979 • 82 citations

Pineal Serotonin N -Acetyltransferase Activity: Abrupt Decrease in Adenosine 3′,5′-Monophosphate May Be Signal for "Turnoff"

1978 • 81 citations

The Effect of Desipramine upon Melatonin and Cortisol Secretion in Depressed and Normal Subjects

1985 • 78 citations

The adrenal medulla may mediate the increase in pineal melatonin synthesis induced by stress, but not that caused by exposure to darkness

1977 • 76 citations

<b>VASOACTIVE INTESTINAL POLYPEPTIDE STIMULATES ADENYLATE CYCLASE AND SEROTONIN <i>N</i>-ACETYLTRANSFERASE ACTIVITIES IN RAT PINEAL <i>IN </i></b><b><i>VITRO </i></b>

1980 • 75 citations

The pineal gland: a model of neuroendocrine regulation.

1978 • 73 citations

Disappearance of Plasma Melatonin after Removal of a Neoplastic Pineal Gland

1983 • 70 citations

Melatonin, pituitary function and stress in humans

1979 • 70 citations

Vasoactive intestinal peptide (VIP) occurs in nerves of the pineal gland

1980 • 66 citations

Circadian Rhythm in Pineal Serotonin: Effect of Monoamine Oxidase Inhibition and Reserpine

1965 • 65 citations

Rat Pinealα₁-Adrenoceptors: Identification and Characterization Using [¹²⁵I]Iodo-2-[β-(4-Hydroxyphenyl)-Ethylaminomethyl]Tetralone

1984 • 61 citations

Daily Rhythm of Plasma Melatonin in Normal and Precocious Puberty*

1982 • 60 citations

Control of pineal N-acetylserotonin by a beta adrenergic receptor.

1973 • 59 citations

Regulation of noradrenaline release in the rat pineal through a negative feedback mechanism mediated by presynaptic α-adrenoceptors

1977 • 58 citations

Clonidine reduces plasma melatonin levels

1986 • 58 citations

Kinetic and fluorescent histochemical analysis of the serotonin compartments in rat pineal gland

1969 • 57 citations

The influence of the frequency and pattern of sympathetic nerve activity on serotonin N‐acetyltransferase in the rat pineal gland.

1982 • 57 citations

The Daily Profile of Plasma Melatonin in Obese and Prader-Willi Syndrome Children

1982 • 56 citations

Stimulation of adenylate cyclase activity in different areas of human brain by substance P

1975 • 54 citations

Plasma melatonin during desmethylimipramine treatment: evidence for changes in noradrenergic transmission.

1985 • 53 citations

Factors Influencing Melatonin, 5-Hydroxytryptophol, 5-Hydroxyindoleacetic Acid, 5-Hydroxytryptamine and Tryptophan in Rat Pineal Glands

1982 • 51 citations

Melatonin, Light and Chronobiological Disorders

1985 • 51 citations

Patterns of melatonin rhythms in depression.

1986 • 51 citations

Human plasma melatonin is elevated during treatment with the monoamine oxidase inhibitors clorgyline and tranylcypromine but not deprenyl

1986 • 50 citations

Ovine Pineal α₁-Adrenoceptors: Characterization and Evidence for a Functional Role in the Regulation of Serum Melatonin

1985 • 48 citations

Selective inhibition of MAO-A but not MAO-B activity increases rat pineal melatonin

1985 • 47 citations

Effect of naloxone on the nocturnal rise of rat pineal melatonin content

1984 • 47 citations

Distribution of Substance P Neurons in the Epithalamus of the Rat: An Immunohistochemical Investigation

1984 • 47 citations

Taurine Modulation of the Benzodiazepine‐γ‐Aminobutyric Acid Receptor Complex in Brain Membranes

1984 • 47 citations

Desmethylimipramine treatment increases melatonin production in humans

1986 • 44 citations

<b>RECEPTORS FOR VASOACTIVE INTESTINAL POLYPEPTIDE ON RAT DISPERSED PINEAL </b><b>CELLS </b>

1983 • 41 citations

Psychoneuroendocrinology

1986 • 40 citations

The effect of chronic antidepressant administration on β‐adrenoceptor function of the rat pineal

1983 • 39 citations

URINARY 6‐SULPHATOXY MELATONIN EXCRETION DURING THE HUMAN MENSTRUAL CYCLE

1982 • 39 citations

Light and Agonists Alter Pineal N -Acetyltransferase Induction by Vasoactive Intestinal Polypeptide

1983 • 37 citations

Comparison of the Effects of β‐Adrenergic Agents on Pineal Serotonin N‐Acetyltransferase Activity and Melatonin Content in Two Species of Hamsters

1984 • 36 citations

Pharmacological Studies on the Regulation of N‐Acetyltransferase Activity and Melatonin Content of the Pineal Gland of the Syrian Hamster

1985 • 35 citations

Antidepressant drugs with varying pharmacological profiles alter rat pineal beta adrenergic-mediated function.

1984 • 34 citations

Serum melatonin and pineal indoleamine metabolism in a species with a small day/night rhythm

1985 • 34 citations

Role of the Pineal Gland in the Photoperiodic Control of Reproductive and Non‐Reproductive Functions in Mink ( Mustela vison )

1985 • 34 citations

Taurine: Stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism

1979 • 33 citations

Pineal N-acetyltransferase Activity in Blinded and Anosmic Male Rats12

1971 • 32 citations

Role of Prostaglandins in Rat Pineal Neuroeffector Junction. Changes in Melatonin and Norepinephrine Release in Vitro*

1982 • 31 citations

LH AND MELATONIN SECRETION PATTERNS IN PUBERTAL BOYS

1978 • 31 citations

Molecular mechanisms of neuroendocrine integration in the central nervous system: An approach through the study of the pineal gland and its innervating sympathetic pathway

1983 • 30 citations

Pineal Function in Burns: Melatonin Is Not a Marker for General Sympathetic Activity

1985 • 29 citations

The Kinetics of Norepinephrine-induced Stimulation of Serotonin N-Acetyltransferase in Bovine Pineal Gland

1980 • 29 citations

Studies on Melatonin and Other Pineal Factors

1982 • 29 citations

NOREPINEPHRINE INCREASES THE [³²P]LABELLING OF A SPECIFIC PHOSPHOLIPID FRACTION OF POST‐SYNAPTIC PINEAL MEMBRANES

1972 • 29 citations

Clinical studies of the effect of (+) and (?)-oxaprotiline upon noradrenaline uptake

1985 • 29 citations

Benzodiazepines: rat pinealocyte binding sites and augmentation of norepinephrine-stimulated N-acetyltransferase activity.

1984 • 26 citations

Benzodiazepine binding sites in human pineal gland

1984 • 25 citations

Light and Agonist Alter Vasoactive Intestinal Peptide Binding and Intracellular Accumulation of Adenosine 3′,5′-Monophosphate in the Rat Pineal Gland

1985 • 24 citations

Effect of Indomethacin on Monoamine Metabolism and Melatonin Synthesis in Rat Pineal Gland

1980 • 24 citations

A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures

1981 • 23 citations

DOWN-REGULATION AT PINEAL β-ADRENOCEPTORS IN DEPRESSED PATIENTS TREATED WITH DESIPRAMINE?

1983 • 23 citations

In vivo responses of the pineal gland of the Syrian hamster to isoproterenol or norepinephrine.

1982 • 21 citations

Characterization of Flunitrazepam and Beta-Carboline High Affinity Binding in Bovine Pineal Gland

1983 • 21 citations

Regulation of Rat Pineal Hydroxyindole‐O‐Methyltransferase: Evidence of S‐Adenosylmethionine‐Mediated Glucocorticoid Control

1980 • 19 citations

Neuroendocrine and Other Studies of the Mechanism of Antidepressant Action of Desipramine

2007 • 18 citations

The Role of Rhythms in the Response to Melatonin

1985 • 17 citations

Melatonin Rhythms in Human Serum

1981 • 16 citations

A Study of Sulphatoxymelatonin Excretion and Gonadotropin Status During Weight Gain in Anorexia Nervosa

1988 • 16 citations

Decrease of serotonin N-acetyltransferase activity in rat pineal organs after treatment with prostaglandin synthesis inhibitor indomethacin

1976 • 14 citations

NOCTURNAL URINARY MELATONIN EXCRETION AND PLASMA CORTISOL LEVELS IN CHILDREN AND ADOLESCENTS AFTER A SINGLE ORAL DOSE OF DEXAMETHASONE

1986 • 14 citations

24 HOUR MELATONIN SECRETORY PATTERN IN CUSHING'S SYNDROME

1983 • 14 citations

Modulation of rat pineal acetyl-Co A:arylamine N-acetyltransferase induction by alpha adrenergic drugs.

1984 • 12 citations

Effects of steroids on β-adrenergic binding sites in sheep pineal glands

1982 • 11 citations

Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro

1982 • 11 citations

Des-Try-γ-endorphin (DTγE) and pineal levels of melatonin and arginine vasopressin (AVP)

1981 • 9 citations