Total-Genome Analysis of BRCA1/2-Related Invasive Carcinomas of the Breast Identifies Tumor Stroma as Potential Landscaper for Neoplastic Initiation

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

Molecular characterization of the tumor microenvironment in breast cancer

2004 • 1,278 citations

BRCA1 and BRCA2: 1994 and beyond

2004 • 941 citations

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

2021 • 875 citations

Breast Cancer Facts and Figures 2000

2000 • 519 citations

A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes

2002 • 483 citations

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

2002 • 424 citations

Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.

2000 • 400 citations

A role for mitochondrial enzymes in inherited neoplasia and beyond

2003 • 387 citations

Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression.

2001 • 284 citations

Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors.

2002 • 251 citations

Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions

2001 • 189 citations

The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications

2005 • 182 citations

Distinct Genomic Profiles in Hereditary Breast Tumors Identified by Array-Based Comparative Genomic Hybridization

2005 • 164 citations

Risk Factors for Breast Cancer According to Family History of Breast Cancer

1996 • 157 citations

Stromal Regulation of Neoplastic Development

2005 • 157 citations

Combined Total Genome Loss of Heterozygosity Scan of Breast Cancer Stroma and Epithelium Reveals Multiplicity of Stromal Targets

2004 • 143 citations

Mechanisms of common fragile site instability

2005 • 140 citations

Mammary Gland Architecture as a Determining Factor in the Susceptibility of the Human Breast to Cancer

2001 • 122 citations

Pooled Analysis of Loss of Heterozygosity in Breast Cancer: a Genome Scan Provides Comparative Evidence for Multiple Tumor Suppressors and Identifies Novel Candidate Regions

2003 • 105 citations

Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes

2004 • 92 citations

New highlights on stroma–epithelial interactions in breast cancer

2004 • 82 citations

Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas.

1997 • 70 citations

Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors

2005 • 68 citations

TP53 mutation, allelism and survival in non-small cell lung cancer

2005 • 68 citations

Patterns of Allelic Loss of Synchronous Adenocarcinomas of the Lung

2005 • 59 citations

Loss of heterozygosity in normal breast epithelial tissue and benign breast lesions in BRCA1/2 carriers with breast cancer

2004 • 43 citations

Allele Imbalance, or Loss of Heterozygosity, in Normal Breast Epithelium of Sporadic Breast Cancer Cases and BRCA1 Gene Mutation Carriers Is Increased Compared With Reduction Mammoplasty Tissues

2005 • 40 citations

Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families

2005 • 37 citations

Clinically significant cancer evolves from transient mutated and/or aneuploid neoplasia by cell fusion to form unstable syncytia that give rise to ecologically viable parasite species

2005 • 26 citations

The cell clone ecology hypothesis and the cell fusion model of cancer progression and metastasis: History and experimental support

2005 • 25 citations

A study of chromosome aneuploidy in hereditary breast cancer patients and their healthy blood relatives.

2001 • 7 citations