Dual effect of serotonin on formalin-induced nociception in the rat spinal cord

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Modified formalin test: characteristic biphasic pain response

1989 • 971 citations

Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding

1992 • 681 citations

Molecular biology of 5-HT receptors

1994 • 679 citations

5-HT3 receptors are membrane ion channels

1989 • 630 citations

Spinal serotonin terminal system mediates antinociception

1981 • 504 citations

Nervous system distribution of the serotonin 5-HT3 receptor mRNA.

1993 • 369 citations

Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA

1991 • 259 citations

Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord

1993 • 185 citations

5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord

1989 • 184 citations

Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems

1991 • 165 citations

Efflux of 5‐hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla.

1985 • 164 citations

5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals

1993 • 162 citations

Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord

1983 • 142 citations

Autoradiographic evidence of serotonin1 binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord

1987 • 138 citations

Central and peripheral 5-HT3 receptors

1992 • 137 citations

Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats.

1988 • 132 citations

5-HT3 receptors modulate spinal nociceptive reflexes

1990 • 132 citations

Reversal of the antinociceptive effects of intrathecally administered serotonin in the rat by a selective 5-HT3 receptor antagonist

1988 • 126 citations

Changes in nociception after lesions of descending serotonergic pathways induced with 5,6-dihydroxytryptamine

1985 • 97 citations

Intrathecal serotonin in mice: Analgesia and inhibition of a spinal action of substance P

1983 • 90 citations

Increase of serotonin metabolism within the dorsal horn of the spinal cord during nucleus raphe magnus stimulation, as revealed by in vivo electrochemical detection

1982 • 85 citations

Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain

1986 • 79 citations

Serotonin preferentially hyperpolarizes capsaicin-sensitive C type sensory neurons by activating 5-HT1A receptors

1992 • 56 citations

5-HT<sub>1A</sub> Receptors Mediate the Effect of the Bulbospinal Serotonin System on Spinal Dorsal Horn Nociceptive Neurons

1994 • 55 citations

5-HT3, receptor antagonists inhibit sensory neuropeptide release from the rat spinal cord

1990 • 55 citations

Selective serotonin1A/1B agonists differentially affect spinal nociceptive reflexes

1990 • 53 citations

The role of 5-HT1A and 5-HT1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour

1992 • 43 citations

Similar behavioural effects of 5-hydroxytryptamine and substance P injected intrathecally in mice

1983 • 36 citations

Different function of spinal 5-HT1A and 5-HT2 receptor subtypes in modulating behaviour induced by excitatory amino acid receptor agonists in mice

1993 • 30 citations

Serotonin inhibits high-threshold Ca2+ channel currents in capsaicin-sensitive acutely isolated adult rat DRG neurons

1994 • 29 citations

Changes in nociception after 6-hydroxydopamine lesions of descending catecholaminergic pathways in mice

1986 • 27 citations

Effect of subcutaneous administration of the chemical algogen formalin, on 5-HT metabolism in the nucleus raphe magnus and the medullary dorsal horn: a voltammetric study in freely moving rats

1992 • 25 citations

Pharmacological characterization of 5-hydroxytryptamine2 and 5-hydroxytryptamine3 receptors in rat dorsal root ganglion cells.

1990 • 22 citations

Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks

1989 • 21 citations

Increased behavioural response to intrathecal serotonin after lesion of serotonergic pathways with 5,7‐dihydroxytryptamine seems not to be due to depletion of serotonin

1988 • 17 citations