Myocardial No-Reflow in Humans

Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year

1995 • 1,586 citations

Prognostic Significance of Microvascular Obstruction by Magnetic Resonance Imaging in Patients With Acute Myocardial Infarction

1998 • 1,364 citations

Angiographic Assessment of Myocardial Reperfusion in Patients Treated With Primary Angioplasty for Acute Myocardial Infarction

1998 • 1,277 citations

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

2008 • 1,256 citations

Thrombus Aspiration during Primary Percutaneous Coronary Intervention

2008 • 1,047 citations

Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up study

2008 • 891 citations

Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.

1983 • 845 citations

Atherothrombosis and High-Risk Plaque

2005 • 721 citations

Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial

2007 • 660 citations

A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Adenosine as an Adjunct to Reperfusion in the Treatment of Acute Myocardial Infarction (AMISTAD-II)

2005 • 567 citations

Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction

1999 • 535 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker.

1994 • 476 citations

Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow.

1989 • 468 citations

Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials

2007 • 462 citations

Impact of Microvascular Dysfunction on Left Ventricular Remodeling and Long-Term Clinical Outcome After Primary Coronary Angioplasty for Acute Myocardial Infarction

2004 • 414 citations

Beneficial Effects of Intracoronary Adenosine as an Adjunct to Primary Angioplasty in Acute Myocardial Infarction

2000 • 408 citations

Association between hyperglycemia and the no-reflow phenomenon inpatients with acute myocardial infarction

2002 • 390 citations

Relationship of the TIMI Myocardial Perfusion Grades, Flow Grades, Frame Count, and Percutaneous Coronary Intervention to Long-Term Outcomes After Thrombolytic Administration in Acute Myocardial Infarction

2002 • 386 citations

Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction

1999 • 372 citations

Angiographic Assessment of Reperfusion in Acute Myocardial Infarction by Myocardial Blush Grade

2003 • 371 citations

Microvascular Obstruction and the No-Reflow Phenomenon After Percutaneous Coronary Intervention

2008 • 370 citations

Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction?

1993 • 344 citations

Manual Thrombus-Aspiration Improves Myocardial Reperfusion

2005 • 342 citations

Mean Platelet Volume on Admission Predicts Impaired Reperfusion and Long-Term Mortality in Acute Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

2005 • 341 citations

Reperfusion injury: Experimental evidence and clinical implications

1999 • 333 citations

The coronary no-reflow phenomenon: a review of mechanisms and therapies

2001 • 319 citations

Intracoronary Compared With Intravenous Bolus Abciximab Application in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

2008 • 301 citations

Time to Treatment in Primary Percutaneous Coronary Intervention

2007 • 300 citations

Mediation of Cardioprotection by Transforming Growth Factor-β

1990 • 292 citations

Rheolytic Thrombectomy With Percutaneous Coronary Intervention for Infarct Size Reduction in Acute Myocardial Infarction

2006 • 288 citations

Angiographic Morphologic Features of Infarct-Related Arteries and Timely Reperfusion in Acute Myocardial Infarction

2002 • 282 citations

Coronary microembolization*1

2004 • 281 citations

Tissue osmolality, cell swelling, and reperfusion in acute regional myocardial ischemia in the isolated porcine heart.

1981 • 264 citations

Beneficial Effect of Intracoronary Verapamil on Microvascular and Myocardial Salvage in Patients With Acute Myocardial Infarction

1997 • 257 citations

PATHOPHYSIOLOGY OF ISCHEMIA REPERFUSION INJURY

2000 • 253 citations

Abciximab in primary coronary stenting of ST-elevation myocardial infarction: a European meta-analysis on individual patients' data with long-term follow-up

2007 • 243 citations

Prognostic Impact of Early ST-Segment Resolution in Acute ST-Elevation Myocardial Infarction

2004 • 240 citations

A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction

2002 • 231 citations

The no-reflow phenomenon: A basic mechanism of myocardial ischemia and reperfusion

2006 • 212 citations

Effect of No-Reflow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction on Six-Month Mortality

2006 • 208 citations

Coronary no‐reflow phenomenon: From the experimental laboratory to the cardiac catheterization laboratory

2008 • 204 citations

Combined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction

2005 • 195 citations

Role of adenosine in hyperemic response of coronary blood flow in microembolization

1986 • 193 citations

The Extent of Microvascular Damage During Myocardial Contrast Echocardiography Is Superior to Other Known Indexes of Post-Infarct Reperfusion in Predicting Left Ventricular Remodeling

2008 • 192 citations

Predictive factors for development of the no-reflow phenomenon in patients with reperfused anterior wall acute myocardial infarction

2001 • 192 citations

Prognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarction

2004 • 187 citations

Intravenous atrial natriuretic peptide prevents left ventricular remodeling in patients with first anterior acute myocardial infarction

2001 • 165 citations

Value of Platelet Reactivity in Predicting Response to Treatment and Clinical Outcome in Patients Undergoing Primary Coronary Intervention

2006 • 141 citations

Intracoronary nitroprusside for the prevention of the no-reflow phenomenon after primary percutaneous coronary intervention in acute myocardial infarction. A randomized, double-blind, placebo-controlled clinical trial

2006 • 123 citations

Temporal evolution and functional outcome of no reflow: sustained and spontaneously reversible patterns following successful coronary recanalisation

2003 • 121 citations

Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: Role of inhibitory effect on reactive oxygen species formation

2004 • 119 citations

The effect of acute hypercholesterolemia on myocardial infarct size and the no-reflow phenomenon during coronary occlusion-reperfusion.

1987 • 118 citations

Distal embolization during primary angioplasty: Histopathologic features and predictability

2005 • 113 citations

Chronic pre-treatment of statins is associated with the reduction of the no-reflow phenomenon in the patients with reperfused acute myocardial infarction

2006 • 112 citations

Endothelin-1 and acute myocardial infarction: a no-reflow mediator after successful percutaneous myocardial revascularization

2006 • 108 citations

Pathophysiology of Myocardial Infarction

2008 • 103 citations

The sequential changes in myocardial thickness and thickening which occur during acute transmural infarction, infarct reperfusion and the resultant expression of reperfusion injury

2004 • 100 citations

Intracoronary verapamil for reversal of no‐reflow during coronary angioplasty for acute myocardial infarction

2002 • 97 citations

Adjunctive devices in primary or rescue PCI: A meta-analysis of randomized trials

2007 • 96 citations

High dose adenosine for suboptimal myocardial reperfusion after primary PCI: A randomized placebo‐controlled pilot study

2007 • 96 citations

Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury

2006 • 96 citations

Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury

2000 • 95 citations

Coronary microembolization

2006 • 90 citations

Detection of embolic particles with the Doppler guide wire during coronary intervention in patients with acute myocardial infarction

2005 • 85 citations

Effects of the Nitric Oxide Donor Nitroprusside on No-Reflow Phenomenon During Coronary Interventions for Acute Myocardial Infarction

2005 • 85 citations

Left ventricular remodeling after primary coronary angioplasty in patients treated with abciximab or intracoronary adenosine

2005 • 84 citations

Predictors of outcome in patients undergoing PCI. Results of the RIVIERA study

2007 • 83 citations

Ischemic preconditioning and preinfarction angina in the clinical arena

2004 • 80 citations

Myocardial contrast echocardiography in acute myocardial infarction: Pathophysiological background and clinical applications

1996 • 79 citations

Comparison in patients having primary coronary angioplasty of abciximab versus tirofiban on recovery of left ventricular function

2004 • 78 citations

Thrombus Aspiration Reduces Microvascular Obstruction After Primary Coronary Intervention

2006 • 78 citations

Ischemia-Reperfusion Injury at the Microvascular Level

2000 • 77 citations

Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention

2008 • 70 citations

Myocardial contrast echocardiography in ST elevation myocardial infarction: ready for prime time?

2008 • 70 citations

Assessment of no-reflow regions using cardiac MRI

2006 • 65 citations

Natriuretic peptides and myocardial ischaemia

2004 • 64 citations

Usefulness of myocardial blush grade early and late after primary coronary angioplasty for acute myocardial infarction in predicting left ventricular function

2003 • 59 citations

Combined assessment of thrombolysis in myocardial infarction flow grade, myocardial perfusion grade, and ST-segment resolution to evaluate epicardial and myocardial reperfusion

2004 • 55 citations

Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs

1996 • 54 citations

No-Reflow Phenomenon After Acute Myocardial Infarction Is Associated With Reduced Clot Permeability and Susceptibility to Lysis

2007 • 52 citations

Relation Between Neutrophil Counts on Admission, Microvascular Injury, and Left Ventricular Functional Recovery in Patients With an Anterior Wall First Acute Myocardial Infarction Treated With Primary Coronary Angioplasty

2007 • 52 citations

Relation of Myocardial Blush Grade to Microvascular Perfusion and Myocardial Infarct Size After Primary or Rescue Percutaneous Coronary Intervention

2007 • 50 citations

Baseline systemic inflammatory status and no-reflow phenomenon after percutaneous coronary angioplasty for acute myocardial infarction

2006 • 50 citations

The acute reperfusion management of STEMI in patients with impaired glucose tolerance and type 2 diabetes

2005 • 49 citations

Effects of leukocyte activation on myocardial vascular resistance.

1990 • 45 citations

Nicorandil reduces myocardial infarct size by opening the Katp channel in rabbits

1997 • 44 citations

Level of Selvester QRS score is predictive of ST-segment resolution and 30-day outcomes in patients with acute myocardial infarction undergoing primary coronary intervention

2006 • 40 citations

Ethanol Abolishes Ischemic Preconditioning in Humans

2008 • 39 citations

Association of C-reactive protein and myocardial perfusion in patients with ST-elevation acute myocardial infarction

2005 • 38 citations

Decreased no-reflow in patients with anterior myocardial infarction and pre-infarction angina

1999 • 37 citations

Frequency of Slow Coronary Flow Following Successful Stent Implantation and Effect of Nitroprusside

2007 • 27 citations

Depletion of antioxidants is associated with no‐reflow phenomenon in acute myocardial infarction

2004 • 27 citations

Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion

2006 • 26 citations

Carvedilol preserves endothelial junctions and reduces myocardial no-reflow after acute myocardial infarction and reperfusion

2006 • 23 citations

Prospective, Multicenter Study of Thrombectomy in Patients with Acute Myocardial Infarction: The X‐Tract AMI Registry

2007 • 20 citations

Contemporary outcomes of rescue percutaneous coronary intervention for acute myocardial infarction: Comparison with primary angioplasty and the role of distal protection devices (EMERALD trial)

2008 • 16 citations

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