Immune activation modulates hematopoiesis through interactions between CD27 and CD70

Osteoblastic cells regulate the haematopoietic stem cell niche

2003 • 3,370 citations

Identification of the haematopoietic stem cell niche and control of the niche size

2003 • 2,900 citations

Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

2004 • 1,929 citations

Socializing with the Neighbors

2004 • 1,711 citations

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

1998 • 1,145 citations

Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application

2003 • 974 citations

Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells

2001 • 769 citations

Cellular Niches Controlling B Lymphocyte Behavior within Bone Marrow during Development

2004 • 757 citations

CD27 is required for generation and long-term maintenance of T cell immunity

2000 • 726 citations

Upregulation of Flt3 Expression within the Bone Marrow Lin−Sca1+c-kit+ Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity

2001 • 691 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow

2002 • 460 citations

Bone marrow is a major site of long-term antibody production after acute viral infection

1995 • 384 citations

Flow cytometric identification of murine neutrophils and monocytes

1996 • 357 citations

CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool

2003 • 355 citations

Bone marrow as a priming site for T-cell responses to blood-borne antigen

2003 • 343 citations

Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse

1991 • 267 citations

B cell memory and the long-lived plasma cell

1999 • 250 citations

Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation.

1995 • 239 citations

CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-κB and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-κB-inducing Kinase

1998 • 239 citations

Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion

2001 • 237 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen.

1987 • 231 citations

Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation

2003 • 215 citations

Generation of Plasma Cells From Peripheral Blood Memory B Cells: Synergistic Effect of Interleukin-10 and CD27/CD70 Interaction

1998 • 204 citations

Expression of the Murine CD27 Ligand CD70 In Vitro and In Vivo

2003 • 193 citations

Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor

1993 • 185 citations

Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro.

1984 • 180 citations

CD27-CD70 interactions regulate B-cell activation by T cells.

1995 • 179 citations

Characterization of the human CD27 ligand, a novel member of the TNF gene family.

1994 • 171 citations

Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization

1995 • 166 citations

Tumor Rejection Induced by CD70-mediated Quantitative and Qualitative Effects on Effector CD8+ T Cell Formation

2004 • 149 citations

The cloning of CD70 and its identification as the ligand for CD27.

1994 • 139 citations

CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling.

1997 • 136 citations

CD27 Is Acquired by Primed B Cells at the Centroblast Stage and Promotes Germinal Center Formation

2004 • 134 citations

Characterization of murine CD70 by molecular cloning and mAb

1998 • 113 citations

Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators

2001 • 108 citations

Expression of CD27 on Murine Hematopoietic Stem and Progenitor Cells

2000 • 105 citations

Self-Renewal of Multipotent Long-Term Repopulating Hematopoietic Stem Cells Is Negatively Regulated by FAS and Tumor Necrosis Factor Receptor Activation

2001 • 103 citations

Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors.

1991 • 94 citations

CD27/CD70 Interaction Augments IgE Secretion by Promoting the Differentiation of Memory B Cells into Plasma Cells

1998 • 91 citations

Essential Role for the P55 Tumor Necrosis Factor Receptor in Regulating Hematopoiesis at a Stem Cell Level

1999 • 89 citations

The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2

1998 • 88 citations

Bone Marrow and Thymus Expression of Interferon-γ Results in Severe B-Cell Lineage Reduction, T-Cell Lineage Alterations, and Hematopoietic Progenitor Deficiencies

1997 • 86 citations

Sustained engraftment of mice transplanted with IL-1-primed blood-derived stem cells.

1992 • 70 citations

Antigen‐presenting cell‐derived signals determine expression levels of CD70 on‘qc primed T cells

1997 • 60 citations

Culture of hematopoietic cells

1994 • 51 citations

Combined measurement of growth and differentiation in suspension cultures of purified human CD34-positive cells enables a detailed analysis of myelopoiesis.

1992 • 16 citations