The Role of Glucocorticoids in Secretory Activation and Milk Secretion, a Historical Perspective

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.

1995 • 926 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue

1979 • 437 citations

Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!

2007 • 354 citations

Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium

1996 • 292 citations

Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor.

1991 • 284 citations

Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine

2006 • 249 citations

Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland.

1995 • 238 citations

Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene.

1996 • 238 citations

Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells.

1990 • 217 citations

REGULATION OF MILK PROTEIN GENE EXPRESSION

1999 • 217 citations

Complex hormonal regulation of rat casein gene expression.

1982 • 204 citations

Functional Development of the Mammary Gland: Use of Expression Profiling and Trajectory Clustering to Reveal Changes in Gene Expression During Pregnancy, Lactation, and Involution

2003 • 202 citations

Specific DNA Binding of Stat5, but Not of Glucocorticoid Receptor, Is Required for Their Functional Cooperation in the Regulation of Gene Transcription

1997 • 184 citations

Hormonal regulation of tight junction closure in the mouse mammary epithelium during the transition from pregnancy to lactation

2001 • 181 citations

Genetic dissection of glucocorticoid receptor function in mice

1998 • 173 citations

Time course of milk accumulation-induced opening of mammary tight junctions, and blood clearance of milk components

1997 • 165 citations

Characterization of Stat5a and Stat5b Homodimers and Heterodimers and Their Association with the Glucocortiocoid Receptor in Mammary Cells

1998 • 164 citations

Multiple Hormone Interactions in the Development of Mammary Gland in Vitro

1970 • 161 citations

Glucocorticoid-induced formation of tight junctions in mouse mammary epithelial cells in vitro.

1992 • 152 citations

SOME ULTRASTRUCTURAL EFFECTS OF INSULIN, HYDROCORTISONE, AND PROLACTIN ON MAMMARY GLAND EXPLANTS

1970 • 140 citations

Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression.

1995 • 128 citations

Prolactin induction of casein mRNA in organ culture. A model system for studying peptide hormone regulation of gene expression.

1978 • 126 citations

The differential actions of cortisol on the accumulation of α-lactalbumin and casein in midpregnant mouse mammary gland in culture

1980 • 124 citations

Promoter-dependent Synergy between Glucocorticoid Receptor and Stat5 in the Activation of β-Casein Gene Transcription

1997 • 123 citations

INFLUENCE OF HORMONES ON LOBULO-ALVEOLAR DIFFERENTIATION OF MOUSE MAMMARY GLANDS IN VITRO

1966 • 123 citations

Glucocorticoid Receptor/Signal Transducer and Activator of Transcription 5 (STAT5) Interactions Enhance STAT5 Activation by Prolonging STAT5 DNA Binding and Tyrosine Phosphorylation

1999 • 123 citations

Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family

1999 • 120 citations

Increased Exposure of Tissues to Cortisol in Late Pregnancy

1970 • 116 citations

A compilation of composite regulatory elements affecting gene transcription in vertebrates

1995 • 98 citations

Hormone-dependent Accumulation of Rough Endoplasmic Reticulum in Mouse Mammary Epithelial Cells in Vitro

1971 • 98 citations

Specific cytoplasmic glucocorticoid hormone receptors in lactating mammary glands

1973 • 96 citations

Transcriptional Changes Underlying the Secretory Activation Phase of Mammary Gland Development

2005 • 95 citations

Cooperative Effects of STAT5 (Signal Transducer and Activator of Transcription 5) and C/EBP β (CCAAT/Enhancer-Binding Protein-β) onβ -Casein Gene Transcription Are Mediated by the Glucocorticoid Receptor

2001 • 95 citations

Prolactin and Glucocorticoid Hormones Control Transcription of the β-Casein Gene by Kinetically Distinct Mechanisms

1990 • 92 citations

Prolactin, alone or in combination with glucocorticoids, enhances tight junction formation and expression of the tight junction protein occludin in mammary cells

1999 • 89 citations

INFLUENCE OF INSULIN ON MAINTENANCE AND SECRETORY STIMULATION OF MOUSE MAMMARY TISSUES BY HORMONES IN ORGAN-CULTURE¹

1961 • 88 citations

Progesterone Receptor Repression of Prolactin/Signal Transducer and Activator of Transcription 5-Mediated Transcription of the β-Casein Gene in Mammary Epithelial Cells

2006 • 77 citations

Transcription factor regulation in mammary epithelial cells

2002 • 74 citations

The Epithelial Glucocorticoid Receptor Is Required for the Normal Timing of Cell Proliferation during Mammary Lobuloalveolar Development but Is Dispensable for Milk Production

2004 • 70 citations

Glucocorticoid-Induced Degradation of Glycogen Synthase Kinase-3 Protein Is Triggered by Serum- and Glucocorticoid-Induced Protein Kinase and Akt Signaling and Controls β-Catenin Dynamics and Tight Junction Formation in Mammary Epithelial Tumor Cells

2007 • 68 citations

Effect of Insulin and Cortisol on Organ Cultures of Adult Mouse Mammary Gland.

1959 • 68 citations

Elevated plasma cortisol reduces permeability of mammary tight junctions in the lactating bovine mammary epithelium

1998 • 66 citations

Regulation of enzyme turnover during tissue differentiation. Interactions of insulin, prolactin and cortisol in controlling the turnover of fatty acid synthetase in rabbit mammary gland in organ culture

1976 • 66 citations

Lactogenic Hormone and Cell Type-Specific Control of the Whey Acidic Protein Gene Promoter in Transfected Mouse Cells

1991 • 65 citations

Comparative Proteomic Analysis of Proliferating and Functionally Differentiated Mammary Epithelial Cells

2003 • 64 citations

Absolute requirement of glucocorticoid for expression of the casein gene in the presence of prolactin.

1980 • 64 citations

Expression of stromelysin‐1 and timp‐1 in the involuting mammary gland and in early invasive tumors of the mouse

1994 • 64 citations

Glucocorticoid Down-regulation of Fascin Protein Expression Is Required for the Steroid-induced Formation of Tight Junctions and Cell-Cell Interactions in Rat Mammary Epithelial Tumor Cells

1999 • 61 citations

Secretory activation in the mammary gland: it's not just about milk protein synthesis!

2007 • 61 citations

Effects of adrenalectomy and of treatment with adrenal cortex hormones on the arginase and phosphatase levels of lactating rats

1946 • 61 citations

Requirement for Ras and Phosphatidylinositol 3-Kinase Signaling Uncouples the Glucocorticoid-induced Junctional Organization and Transepithelial Electrical Resistance in Mammary Tumor Cells

1999 • 61 citations

Mammary gland development and lactation are controlled by different glucocorticoid receptor activities

2001 • 60 citations

Glucocorticoid Regulation of Prolactin Receptors on Mammary Cells in Culture*

1979 • 59 citations

Hormone-inducible casein messenger RNA in a serum-free organ culture of whole mammary gland

1977 • 57 citations

Lobuloalveolar Differentiation in Mouse Mammary Tissues in vitro

1964 • 57 citations

Further Studies on the Corticosteroid-Binding Globulin in the Rat: Proposed Endocrine Control

1966 • 56 citations

Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region.

1994 • 56 citations

Glucocorticoid-induced Functional Polarity of Growth Factor Responsiveness Regulates Tight Junction Dynamics in Transformed Mammary Epithelial Tumor Cells

1995 • 55 citations

Mammary Lobulo-Alveolar Growth Induced by Anterior Pituitary Hormones in Adreno-Ovariectomized and Adreno-Ovariectomized-Hypophysectomized Rats.

1961 • 54 citations

Antagonistic Regulation of Tight Junction Dynamics by Glucocorticoids and Transforming Growth Factor-βin Mouse Mammary Epithelial Cells

1996 • 53 citations

Glucocorticoid receptor binding sites in the promoter region of milk protein genes

1993 • 52 citations

Dynamics of Glucocorticoid Receptor and Mineralocorticoid Receptor: Implications from Live Cell Imaging Studies

2007 • 52 citations

Glucocorticoids in Mammary Secretions and Blood Serum during Reproduction and Lactation and Distributions of Glucocorticoids, Progesterone, and Estrogens in Fractions of Milk

1978 • 51 citations

Corticosterone is required for the prolactin receptor gene expression in the late pregnant mouse mammary gland

1997 • 48 citations

Effects of Glucocorticoids on Casein Gene Expression in the Rabbit

1977 • 46 citations

Inhibition by low concentrations of ouabain of prolactin-induced lactogenesis in rabbit mammary-gland explants

1978 • 46 citations

Hormone-Dependent β-Casein mRNA Stabilization Requires Ongoing Protein Synthesis

1989 • 45 citations

Glucocorticoid Down-regulation of RhoA Is Required for the Steroid-induced Organization of the Junctional Complex and Tight Junction Formation in Rat Mammary Epithelial Tumor Cells

2003 • 44 citations

Glucocorticoid modulation of prolactin receptors on mammary cells of lactating mice

1979 • 42 citations

The Mineralocorticoid Receptor May Compensate for the Loss of the Glucocorticoid Receptor at Specific Stages of Mammary Gland Development

2002 • 41 citations

Glucocorticoids and Progesterone Prevent Apoptosis in the Lactating Rat Mammary Gland*

2002 • 39 citations

Induction of Lactation in Pregnant Heifers with 9-Fluoroprednisolone Acetate

1965 • 39 citations

Corticosteroid-binding globulin (CBG) production by hepatic and extra-hepatic sites in the ovine fetus; effects of CBG on glucocorticoid negative feedback on pituitary cells in vitro

1995 • 38 citations

Transcription factors acting on the promoter of the rat fatty acid synthase gene

2002 • 38 citations

Effect of feeding on the diurnal rhythm of plasma cortisol and adrenocorticotrophic hormone concentrations in the pregnant ewe and sheep fetus

1991 • 38 citations

Interactions of insulin, corticosterone and prolactin in promoting milk-fat synthesis by mammary explants from pregnant rabbits

1972 • 38 citations

Retention of glucocorticoid by isolated mammary tissue may complicate interpretation of results from invitro experiments

1979 • 35 citations

Effects of various synthetic glucocorticoids on milk production and blood glucose and ketone body concentrations in normal and ketotic cows.

1970 • 35 citations

Reproductive Functions of Corticotropin‐Releasing Hormone. Research and Potential Clinical Utility of Antalarmins (CRH Receptor Type 1 Antagonists)

2004 • 34 citations

Glucocorticoid induced expression of connective tissue growth factor contributes to lactogenic differentiation of mouse mammary epithelial cells

2007 • 30 citations

Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic mice

2007 • 30 citations

Involvement of the Helix-Loop-Helix Protein Id-1 in the Glucocorticoid Regulation of Tight Junctions in Mammary Epithelial Cells

2000 • 29 citations

Selective glucocorticoid control of Rho kinase isoforms regulate cell–cell interactions

2007 • 28 citations

Glucocorticoids Control β-Catenin Protein Expression and Localization through Distinct Pathways that Can Be Uncoupled by Disruption of Signaling Events Required for Tight Junction Formation in Rat Mammary Epithelial Tumor Cells

2003 • 27 citations

THE EFFECT OF PITUITARY GROWTH HORMONE AND ADRENOCORTICOTROPIC HORMONE ON ESTABLISHED LACTATION

1955 • 27 citations

Transforming Growth Factor-α Abrogates the Glucocorticoid Stimulation of Tight Junction Formation and Reverses the Steroid-Induced Down-regulation of Fascin in Rat Mammary Epithelial Tumor Cells by a Ras-Dependent Pathway

2002 • 26 citations

Role of spermidine in casein gene expression in the rabbit

1978 • 26 citations

The effect of adrenalectomy on the metabolism of the mammary glands of lactating rats

1964 • 26 citations

Influence of glucocorticoids on mammary prolactin receptors in pregnant mice after ovariectomy

1982 • 25 citations

THE EFFECT OF GLUCOCORTICOID ON IMMUNOGLOBULIN SECRETION INTO COLOSTRUM IN COWS

1975 • 25 citations

Regulation of enzyme turnover during tissue differentiation

1977 • 24 citations

Artificial Induction of Lactation in Cattle by Use of Dexamethasone Trimethylacetate

1975 • 24 citations

The differential actions of cortisol on the synthesis and turnover of alpha-lactalbumin and casein and on accumulation of their mRNA in mouse mammary gland in organ culture

1983 • 22 citations

Effects of two glucocorticoids on milk yield and biochemical measurements in healthy and ketotic cows

1987 • 20 citations

[61] Preparation and culture of mammary gland explants

1981 • 19 citations

EFFECTS OF CORTISONE ACETATE ON MILK PRODUCTION AND MAMMARY INVOLUTION IN PARTURIENT RATS¹

1958 • 18 citations

Glucocorticoid Binding in Mammary Tissue Slices of Cattle in Various Reproductive States

1976 • 17 citations

Distribution between Protein-Bound and Free Forms of Plasma Cortisol in the Gilt and Fetal Pig Near Term

1997 • 17 citations

Stimulation of milk secretion with inhibition of milk ejection by corticosteroids during extended lactation in the rat

1984 • 17 citations

Mammary glucocorticoid receptor of mice in pregnancy and in lactation

1976 • 17 citations

Interaction of Steroids with Dexamethasone-Binding Receptor and Corticosteroid-Binding Globulin in the Mammary Gland of the Mouse in Relation to Lactation*

1981 • 17 citations

Hormonal Actions on Mammary Metabolism

1975 • 16 citations

Maintenance of the Mammary Lobulo-Alveolar System in Rats After Adreno-Orchidectomy by Prolactin and Growth Hormone1

1965 • 15 citations

Role of glucocorticoids and progesterone in the development of rough endoplasmic reticulum involved in casein biosynthesis

1979 • 14 citations

Regulatory Sequences Involved in the Hormonal Control of Casein Gene Expression^a

1986 • 11 citations

Secretion of a cysteine proteinase from a hormone-independent cell population of cultured explants of murine mammary gland.

1985 • 11 citations

Regulation of Urokinase-Type Plasminogen Activator Production by Rat Mammary Myoepithelial Cells

1996 • 10 citations

Hormone-Dependent Accumulation of Rough Endoplasmic Reticulum in Mouse Mammary Epithelial Cells <italic>In Vitro</italic><xref ref-type="fn" rid="FN1">1</xref>

1972 • 9 citations

Ultrastructural alterations in mammary glands of pregnant rats after ovariectomy and hysterectomy: Effect of adrenal steroids and prolactin

1979 • 9 citations

Glucocorticoids Maintain the Extracellular Matrix of Differentiated Mammary Tissue During Explant and Whole Organ Culture

2000 • 8 citations

Effect of Adrenalectomy and Glucocorticoid Therapy on Lipid Metabolism of Lactating Rats

1998 • 6 citations

Characterization of the Corticosteroid-Binding Globulin Response to Decidualization in the Hamster*

1989 • 6 citations

Effect of Adrenalectomy and Corticoid Replacement on Mammary Gland Growth in Rats.

1962 • 5 citations

Serum Corticosteroid-binding Globulin (CBG) and Hepatic CBG mRNA Relationships during Hamster Pregnancy: Contribution of Decidualization1

1991 • 4 citations

Glucocorticoid receptor of rat mammary gland during pregnancy and lactation.

1986 • 4 citations

The role of the extracellular matrix and lactogenic hormones in mammary gland apoptosis

1996 • 4 citations

Regulation of plasma corticosteroid-binding globulin in adult cynomolgus monkey (Macaca fascicularis) during different reproductive states

1990 • 3 citations