Fibroblast Growth Factors In The Developing Central Nervous System

Fibroblast growth factors.

2001 • 1,946 citations

Receptor Specificity of the Fibroblast Growth Factor Family

1996 • 1,871 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

1998 • 868 citations

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis

2000 • 847 citations

FGFs, heparan sulfate and FGFRs: complex interactions essential for development

2000 • 771 citations

Midbrain development induced by FGF8 in the chick embryo

1996 • 734 citations

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisy

1998 • 693 citations

Inductive interactions direct early regionalization of the mouse forebrain

1997 • 651 citations

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2

1998 • 593 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

1995 • 569 citations

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1992 • 552 citations

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

1993 • 551 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

Keratinocyte growth factor is required for hair development but not for wound healing.

1996 • 541 citations

Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

1990 • 533 citations

Initiation of neural induction by FGF signalling before gastrulation

2000 • 519 citations

FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung

1998 • 483 citations

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis

1995 • 476 citations

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

1993 • 456 citations

FGF2 Concentration Regulates the Generation of Neurons and Glia from Multipotent Cortical Stem Cells

1997 • 455 citations

Mice homozygous for a targeted disruption of the proto-oncogeneint-2have developmental defects in the tail and inner ear

1993 • 446 citations

Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice

1998 • 437 citations

Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate Proteoglycan

1993 • 420 citations

Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex

2000 • 419 citations

FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression

1999 • 407 citations

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

1991 • 406 citations

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

1992 • 404 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

1999 • 397 citations

Molecular Cloning of a Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, which has a Unique Secretion Property

1993 • 390 citations

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

1995 • 390 citations

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

1996 • 385 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Cloning and growth of multipotential neural precursors: Requirements for proliferation and differentiation

1993 • 381 citations

Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain

1997 • 326 citations

Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice

2000 • 316 citations

Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.

1993 • 287 citations

FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions

1994 • 275 citations

Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system

1994 • 272 citations

Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures

2000 • 268 citations

Purification and characterization of acidic fibroblast growth factor from bovine brain.

1984 • 267 citations

Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro

1990 • 257 citations

Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I.

1991 • 245 citations

Binocular Disparity and the Perception of Depth

1997 • 238 citations

A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1

1997 • 228 citations

FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development

1995 • 223 citations

FGF/FGFR-2(IIIb) Signaling Is Essential for Inner Ear Morphogenesis

2000 • 217 citations

Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene

1999 • 213 citations

Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system

1990 • 212 citations

Functions of fibroblast growth factors in vertebrate development

1996 • 208 citations

Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo

1998 • 199 citations

A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers

1996 • 198 citations

Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression

2000 • 192 citations

Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides

1999 • 189 citations

Prominent expression of acidic fibroblast growth factor in motor and sensory neurons

1991 • 189 citations

Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.

1988 • 181 citations

Multiple roles for FGF-3 during cranial neural development in the chicken

1995 • 176 citations

Early posterior neural tissue is induced by FGF in the chick embryo

1998 • 160 citations

Fibroblast Growth Factor Receptor-1 (FGFR-1) Is Essential for Normal Neural Tube and Limb Development

1997 • 154 citations

Spinal cord neuroblasts proliferate in response to basic fibroblast growth factor

1994 • 151 citations

FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation

1998 • 149 citations

FGF Signaling and the Anterior Neural Induction in Xenopus

1999 • 146 citations

Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis

1995 • 142 citations

Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart

1997 • 139 citations

The Role of FGF-3 in Early Inner Ear Development: An Analysis in Normal andkreislerMutant Mice

1996 • 139 citations

Developmental expression of the Xenopus int-2 (FGF-3) gene: activation by mesodermal and neural induction

1992 • 136 citations

Fibroblast Growth Factor Receptor Signaling Crosstalk in Skeletogenesis

2010 • 132 citations

Evidence that fibroblast growth factor 5 is a major muscle-derived survival factor for cultured spinal motoneurons

1993 • 132 citations

Induction of inner ear fate by FGF3

2000 • 129 citations

Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo

2000 • 129 citations

Expression of basic fibroblast growth factor in the nervous system of early avian embryos

1990 • 128 citations

Expression of fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3) in the developing head and face

1997 • 119 citations

FGF2 regulates proliferation of neural crest cells, with subsequent neuronal differentiation regulated by LIF or related factors

1994 • 118 citations

Genomic structure, mapping, activity and expression of fibroblast growth factor 17

1999 • 115 citations

The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea.

1995 • 106 citations

Structure and Expression of a Novel Fibroblast Growth Factor, FGF-17, Preferentially Expressed in the Embryonic Brain

1998 • 103 citations

6 Fibroblast Growth Factor Signaling Regulates Growth and Morphogenesis at Multiple Steps during Brain Development

1999 • 98 citations

Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties.

1993 • 96 citations

Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development

1996 • 93 citations

Organization and Reorganization of Neuromuscular Junctions in Mice Lacking Neural Cell Adhesion Molecule, Tenascin-C, or Fibroblast Growth Factor-5

1998 • 93 citations

The Regulation of Neural Precursor Cells within the Mammalian Brain

1995 • 89 citations

Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development

1991 • 86 citations

Neural Induction in Whole Chick Embryo Cultures by FGF

1998 • 85 citations

Distinct developmental expression of a new avian fibroblast growth factor receptor

1994 • 82 citations

Distribution of basic fibroblast growth factor in the developing rat brain

1994 • 79 citations

Novel FGF receptor (Z‐FGFR4) is dynamically expressed in mesoderm and neurectoderm during early zebrafish embryogenesis

1995 • 79 citations

Nucleo-cytoplasmic translocation and secretion of fibroblast growth factor-2 during avian gastrulation

1995 • 66 citations

Receptor Binding and Mitogenic Properties of Mouse Fibroblast Growth Factor 3

1995 • 59 citations

Graded interference with FGF signalling reveals its dorsoventral asymmetry at the mid-hindbrain boundary

1999 • 56 citations

Focal delivery of fibroblast growth factor-1 by transfected cells induces spiral ganglion neurite targeting in vitro

1998 • 54 citations

Pax-3 regulates neurogenesis in neural crest-derived precursor cells

1999 • 53 citations

Developmental expression of splicing variants of fibroblast growth factor receptor 3 (FGFR3) in mouse.

1996 • 50 citations

Postgastrulation effects of fibroblast growth factor on Xenopus development

1998 • 46 citations

Characterization of the 1B Promoter of Fibroblast Growth Factor 1 and Its Expression in the Adult and Developing Mouse Brain

1996 • 45 citations

Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development

1999 • 43 citations

Glial expression of fibroblast growth factor-9 in rat central nervous system

1999 • 43 citations

An Important Role for the IIIb Isoform of Fibroblast Growth Factor Receptor 2 in Mesenchymal-Epithelial Signalling during Mouse Organogenesis

2000 • 43 citations

Postgastrulation effects of fibroblast growth factor onXenopus development

1998 • 42 citations

Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture

1993 • 33 citations

Co-localization of FGF-2 and a novel heparan sulphate proteoglycan in embryonic mouse brain

1994 • 30 citations

FGF‐9 is an autocrine/paracrine neurotrophic substance for spinal motoneurons

1999 • 28 citations

Motor neurons in human and rat spinal cord synthesize fibroblast growth factor-9

1997 • 28 citations

Suppression of Fibroblast Growth Factors 1 and 2 by Antisense Oligonucleotides in Embryonic Chick Retinal Cellsin VitroInhibits Neuronal Differentiation and Survival

1998 • 26 citations

Acidic fibroblast growth factor enhances neurite outgrowth and stimulates expression of GAP-43 and Tα1 α-tubulin in cultured neurones from adult rat dorsal root ganglia

1996 • 19 citations

Fgf-R3 is expressed in a subset of chicken spinal motorneurons

1998 • 14 citations

Acidic fibroblast growth factor enhances neurite outgrowth and stimulates expression of GAP-43 and Tα1 α-tubulin in cultured neurones from adult rat dorsal root ganglia

1996 • 1 citations