Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

1991 • 3,177 citations

The rat brain in stereotaxic coordinates (2nd edn)

1987 • 1,743 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

G-protein-coupled receptor heterodimerization modulates receptor function

1999 • 1,146 citations

Neuroleptics and operant behavior: The anhedonia hypothesis

1982 • 1,021 citations

Psychotomimesis Mediated by κ Opiate Receptors

1986 • 822 citations

Regulation of Cocaine Reward by CREB

1998 • 762 citations

Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

2002 • 740 citations

Drug-activation of brain reward pathways

1998 • 679 citations

Dramatic decreases in brain reward function during nicotine withdrawal

1998 • 676 citations

Drug dependence: stress and dysregulation of brain reward pathways

1998 • 652 citations

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

1988 • 599 citations

Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens

2001 • 508 citations

CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli

2002 • 506 citations

Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats

2003 • 473 citations

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.

1993 • 458 citations

Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats

1991 • 441 citations

Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.

1988 • 399 citations

Desipramine Facilitation of Initial Cocaine Abstinence

1989 • 371 citations

Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum

1995 • 364 citations

Decreased brain reward produced by ethanol withdrawal.

1995 • 349 citations

Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors.

1988 • 315 citations

Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect

2002 • 310 citations

Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis.

1994 • 275 citations

Altered responsiveness to cocaine in rats exposed to methylphenidate during development

2001 • 262 citations

Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression

1999 • 250 citations

The curve-shift paradigm in self-stimulation

1986 • 250 citations

Regional and Cellular Mapping of cAMP Response Element-Mediated Transcription during Naltrexone-Precipitated Morphine Withdrawal

2002 • 207 citations

U50,488, a κ opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats

1994 • 171 citations

Dorsal raphe, substantia nigra and locus coeruleus: Interconnections with each other and the neostriatum

1977 • 170 citations

Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum

1993 • 170 citations

A ‘crash’ course on psychostimulant withdrawal as a model of depression

2002 • 154 citations

Cellular Sites for Dynorphin Activation of κ-Opioid Receptors in the Rat Nucleus Accumbens Shell

1999 • 152 citations

Enhanced CREB phosphorylation and changes in c-Fos and FRA expression in striatum accompany amphetamine sensitization

1997 • 130 citations

Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat

1992 • 129 citations

Sensitization to the Behavioral Effects of Cocaine: Modulation by Dynorphin and κ-Opioid Receptor Agonists

1997 • 128 citations

Microinjections of phencyclidine (PCP) and related drugs into nucleus accumbens shell potentiate medial forebrain bundle brain stimulation reward

1996 • 123 citations

Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds

1995 • 117 citations

Quantitative determination of the effects of catecholaminergic agonists and antagonists on the rewarding efficacy of brain stimulation

1987 • 113 citations

Self‐Stimulation and Drug Reward Mechanisms

1992 • 111 citations

Desmethylimipramine attenuates cocaine withdrawal in rats

1992 • 96 citations

Potent and Selective Indolomorphinan Antagonists of the Kappa-Opioid Receptor

2000 • 95 citations

Analysis of [3H] bremazocine binding in single and combinatorial opioid receptor knockout mice

2001 • 69 citations

Dopamine‐dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum

2003 • 51 citations

Identity of the putative δ1-opioid receptor as a δ–κ heteromer in the mouse spinal cord

2003 • 49 citations

Repeated Exposure to Rewarding Brain Stimulation Downregulates GluR1 Expression in the Ventral Tegmental Area

2001 • 41 citations

Effects of naltrexone on nucleus accumbens, lateral hypothalamic and ventral tegmental self-stimulation rate—frequency functions

1988 • 37 citations

Acute and chronic desipramine treatment effects on rewarding electrical stimulation of the lateral hypothalamus

1990 • 22 citations

Inhibition of dopamine efflux in the rat nucleus accumbens during abstinence after free access to d-amphetamine

2002 • 14 citations