Persistently conserved positions in structurally similar, sequence dissimilar proteins: Roles in preserving protein fold and function

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

The Protein Data Bank

2000 • 35,287 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

Identification of common molecular subsequences

1981 • 9,753 citations

SCOP: A structural classification of proteins database for the investigation of sequences and structures

1995 • 6,372 citations

Amino acid substitution matrices from protein blocks.

1992 • 5,998 citations

Divergence measures based on the Shannon entropy

1991 • 4,240 citations

CATH – a hierarchic classification of protein domain structures

1997 • 2,558 citations

Interior and surface of monomeric proteins

1987 • 924 citations

The sequence, crystal structure determination and refinement of two crystal forms of lipase B from Candida antarctica

1994 • 861 citations

Enlarged representative set of protein structures

1994 • 794 citations

Protein superfamilles and domain superfolds

1994 • 779 citations

Helix capping

1998 • 685 citations

Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods

1998 • 560 citations

Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions

1990 • 485 citations

Universally conserved positions in protein folds: reading evolutionary signals about stability, folding kinetics and function

1999 • 419 citations

Alternative packing arrangements in the hydrophobic core of λrepresser

1989 • 375 citations

Systematic mutation of bacteriophage T4 lysozyme

1991 • 341 citations

[36] SSAP: Sequential structure alignment program for protein structure comparison

1996 • 330 citations

Genetic Studies of the lac Repressor. XIV. Analysis of 4000 Altered Escherichia coli lac Repressors Reveals Essential and Non-essential Residues, as well as "Spacers" which do not Require a Specific Sequence

1994 • 278 citations

The FSSP database: fold classification based on structure-structure alignment of proteins

1996 • 260 citations

Identification of side-chain clusters in protein structures by a graph spectral method 1 1Edited by J. M. Thornton

1999 • 251 citations

Genetic Studies of the Lac Repressor XV: 4000 Single Amino Acid Substitutions and Analysis of the Resulting Phenotypes on the Basis of the Protein Structure

1996 • 220 citations

How evolution makes proteins fold quickly

1998 • 186 citations

Stabilization centers in proteins:Identification, characterization and predictions

1997 • 161 citations

A graph-theoretic algorithm for comparative modeling of protein structure

1998 • 157 citations

Structure-based conformational preferences of amino acids

1999 • 143 citations

Pairwise sequence alignment below the twilight zone11Edited by B. Honig

2001 • 139 citations

Dissecting α-helices: Position-specific analysis of α-helices in globular proteins

1998 • 128 citations

Protein stability effects of a complete set of alanine substitutions in Arc repressor

1994 • 123 citations

Evolutionary conservation of the folding nucleus1 1Edited by A. R. Fersht

2001 • 123 citations

Identification of kinetically hot residues in proteins

1998 • 120 citations

Refined X-ray Structures of Haloalkane Dehalogenase at pH 6·2 and pH 8·2 and Implications for the Reaction Mechanism

1993 • 117 citations

Non-functional conserved residues in globins and their possible role as a folding nucleus 1 1Edited by F. E. Cohen

1999 • 117 citations

Expectations from structural genomics

2000 • 110 citations

Structure-derived substitution matrices for alignment of distantly related sequences

2000 • 107 citations

Replacement of Tryptophan Residues in Haloalkane Dehalogenase Reduces Halide Binding and Catalytic Activity

1995 • 60 citations

Characterization of novel proteins based on known protein structures 1 1Edited by R. Huber

2000 • 49 citations

Evaluation of PSI‐BLAST alignment accuracy in comparison to structural alignments

2000 • 42 citations

Conserved key amino acid positions (CKAAPs) derived from the analysis of common substructures in proteins

2000 • 40 citations

Amino Acid Pair Interchanges at Spatially Conserved Locations

1996 • 34 citations

Glimmers in the midnight zone: characterization of aligned identical residues in sequence-dissimilar proteins sharing a common fold.

2000 • 9 citations

Search for a new description of protein topology and local structure.

2000 • 5 citations