Role of Prostaglandins and Arachidonic Acid Derivatives in the Coupling of Cerebral Blood Flow to Cerebral Metabolism

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

Mechanisms of action of transmitters and other substances on smooth muscle.

1979 • 2,193 citations

On the Regulation of the Blood‐supply of the Brain

1890 • 1,743 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

On the local reactions of the arterial wall to changes of internal pressure

1902 • 1,485 citations

Drugs which inhibit prostaglandin biosynthesis.

1974 • 1,325 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.

1977 • 1,093 citations

Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles.

1978 • 1,086 citations

The Effects of Changes in Pa <scp>CO</scp> ₂ Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time

1974 • 1,015 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain

1970 • 854 citations

Insulin effects on monovalent cation transport and Na-K-ATPase activity

1978 • 692 citations

THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUES

1971 • 658 citations

The importance of phospholipase-A2 in prostaglandin biosynthesis

1976 • 647 citations

The prostaglandins: a family of biologically active lipids.

1968 • 613 citations

Free radicals in cerebral ischemia.

1978 • 589 citations

Localization of Functional Activity in the Central Nervous System by Measurement of Glucose Utilization with Radioactive Deoxyglucose

1981 • 572 citations

On the specific vaso‐dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)

1936 • 452 citations

UNSTABLE METABOLITES OF ARACHIDONIC ACID AND THEIR ROLE IN HAEMOSTASIS AND THROMBOSIS

1978 • 447 citations

Inhibition of prostaglandin biosynthesis

1974 • 402 citations

Hypotheses on physiological roles of prostaglandins.

1969 • 400 citations

Blood–Brain Barrier in Physiology and Medicine

1977 • 395 citations

Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin.

1973 • 391 citations

Cerebral arterial spasm

1974 • 390 citations

Polarity of the blood-brain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells

1980 • 389 citations

Amine mechanisms in the cerebral circulation.

1976 • 343 citations

PROSTAGLANDIN E2, PROSTAGLANDIN I2 AND THE VASCULAR CHANGES OF INFLAMMATION

1979 • 343 citations

Analysis of vasoactivity of local pH, PCO2 and bicarbonate on pial vessels.

1977 • 340 citations

Cerebral artery spasm

1978 • 320 citations

STUDIES ON THE ABSORPTION, DISTRIBUTION AND EXCRETION OF INDOMETHACIN IN VARIOUS SPECIES

1966 • 318 citations

Cerebral circulation and norepinephrine: relevance of the blood-brain barrier

1976 • 299 citations

Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats.

1980 • 290 citations

The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits

1977 • 287 citations

Perivascular Potassium and pH as Determinants of Local Pial Arterial Diameter in Cats

1972 • 286 citations

Inhibition of prostaglandin synthesis in man

1972 • 276 citations

Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette.

1977 • 263 citations

Cerebral Arteriolar Damage by Arachidonic Acid and Prostaglandin G ₂

1980 • 245 citations

Brain Edema: Induction in Cortical Slices by Polyunsaturated Fatty Acids

1978 • 242 citations

The Role of Prostaglandins in the Central Nervous System

1979 • 241 citations

Blood Flow and Metabolism in the Brain

1976 • 236 citations

FREE-RADICAL OXIDATION AND ANTIOXIDANTS

1978 • 234 citations

The phosphatidylinositol cycle and the regulation of arachidonic acid production

1981 • 230 citations

Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea‐pig lungs

1973 • 223 citations

Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats.

1981 • 222 citations

Transient cerebral ischemia and brain prostaglandins

1979 • 217 citations

Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

1979 • 206 citations

Endogenous prostaglandins as local regulators of blood flow in man: effect of indomethacin on reactive and functional hyperaemia.

1976 • 202 citations

Prostaglandin I2 and indomethacin prevent impairment of post-ischemic brain reperfusion in the dog.

1979 • 202 citations

Inhibition of Prostaglandin Synthesis and the Response of Baboon Cerebral Circulation to Carbon Dioxide

1973 • 197 citations

Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase

1978 • 193 citations

Prostaglandins, oxygen tension and smooth muscle tone

1972 • 180 citations

CHANGES IN FREE FATTY ACIDS OF BRAIN BY DRUG‐INDUCED CONVULSIONS, ELECTROSHOCK AND ANAESTHESIA

1971 • 180 citations

Effect of pH on ionic exchange and function in rat and rabbit myocardium

1975 • 165 citations

Cerebral arterial smooth muscle contraction by thromboxane A2.

1977 • 159 citations

Nomenclature for leukotrienes

1980 • 157 citations

Prostaglandins and the central nervous system.

1974 • 156 citations

Effect of prostaglandin E2 on central and peripheral catecholamine neurons

1973 • 153 citations

Inhibition of Prostaglandin Synthesis in Rat Brain

1978 • 148 citations

Low concentrations of indomethacin inhibit phospholipase A2 of rabbit polymorphonuclear leukocytes.

1978 • 146 citations

Experimental vasoconstriction of cerebral arteries by prostaglandins

1972 • 143 citations

Contribution of Intrarenal Generation of Prostaglandin to Autoregulation of Renal Blood Flow in the Dog

1973 • 142 citations

Responses of human and baboon arteries to prostaglandin endoperoxides and biologically generated and synthetic prostacyclin: their relevance to cerebral arterial spasm in man.

1979 • 140 citations

Synthesis of prostaglandins and thromboxane B2 by cerebral arteries.

1979 • 135 citations

The effect of indomethacin on the blood flow—metabolism couple in the brain under normal, hypercapnic and hypoxic conditions

1979 • 127 citations

Increase in free Ca2+ in muscle after exposure to CO2

1978 • 122 citations

Features of Astrocytic Function Apparently Involved in the Response of Central Nervous Tissue to Ischemia-Hypoxia

1981 • 117 citations

The effect of indomethacin on cerebral blood flow and oxygen consumption in the rat at normal and increased carbon dioxide tensions

1981 • 115 citations

Prostaglandin Profiles in Tissue and Blood Vessels from Human Brain

1980 • 115 citations

Identification of a smooth muscle-stimulating factor in bovine brain Prostaglandins and related factors 25

1964 • 113 citations

PROSTAGLANDIN ‐ NOREPINEPHRINE INTERACTIONS IN BRAIN: MICROELECTROPHORETIC AND HISTOCHEMICAL CORRELATES

1971 • 110 citations

Prostacyclin release and the modulation of some vasoactive hormones

1980 • 110 citations

The physiology of the cerebral circulation

1973 • 109 citations

Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization

1979 • 109 citations

Biochemical Aspects of Prostaglandins and Thromboxanes

1977 • 107 citations

Regional and species differences in endogenous prostaglandin biosynthesis by brain homogenates

1979 • 106 citations

Prediction of late ischemic complications after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood flow

1980 • 106 citations

Correlation between release of free arachidonic acid and prostaglandin formation in brain cortex and cerebellum

1976 • 105 citations

Experimental Study on the Genesis of Cerebral Vasospasm

1975 • 104 citations

Prostacyclin, indomethacin and the cerebral circulation

1980 • 102 citations

Molecular Aspects of Membrane Structure in Cerebral Edema

1972 • 101 citations

Role of prostaglandin F2a in the genesis of experimental cerebral vasospasm

1972 • 101 citations

Indomethacin inhibits responses to all vasoconstrictors in the rat mesenteric vascular bed: Restoration of responses by prostaglandin E2

1976 • 100 citations

Biosynthesis of Prostacyclin in Rat Cerebral Microvessels and the Choroid Plexus

1981 • 97 citations

Identification of β-adrenergic-sensitive adenylate cyclase in intracranial blood vessels

1979 • 96 citations

Greater Number of Capillary Endothelial Cell Mitochondria in Brain Than in Muscle

1975 • 95 citations

Entry of [3H]norepinephrine, [125I]albumin and evans blue from blood into brain following unilateral osmotic opening of the blood-brain barrier

1978 • 94 citations

Lamb ductus arteriosus: Effect of prostaglandin synthesis inhibitors on the muscle tone and the response to prostaglandin E2

1975 • 94 citations

Role of prostaglandin F2 in human cerebral vasospasm

1974 • 89 citations

Measurement of prostaglandin F2α levels in human cerebrospinal fluid in normal and pathological conditions

1975 • 88 citations

Effects of prostacyclin on the canine isolated basilar artery

1979 • 88 citations

Response of the cerebral circulation in baboons to changing perfusion pressure after indomethacin.

1977 • 87 citations

Cerebral Arterial Spasm

1981 • 86 citations

Facilitated transport of prostaglandins across the blood—cerebrospinal fluid and blood—brain barriers

1976 • 85 citations

Effect of anti‐inflammatory drugs on the binding of calcium to cellular membranes in various human and guinea‐pig tissues

1973 • 84 citations

Altered levels of PGF in cat spinal cord tissue following traumatic injury

1976 • 84 citations

Are prostaglandins involved in experimental ischemic edema in gerbils?

1981 • 83 citations

Autoradiographic distribution studies of 3h-labeled prostaglandin e1 in mice. prostaglandins and related factors 31

1965 • 83 citations

Prostaglandins and the Central Nervous System

1974 • 79 citations

Effects of indomethacin on regional blood flow in conscious rabbits—a microsphere study

1979 • 76 citations

Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs

1972 • 74 citations

The effects of prostaglandins E1, A1, and F2a on the cerebral circulation of dogs and monkeys

1972 • 72 citations

Role of prostaglandins in pial arteriolar response to CO2 and hypoxia

1980 • 72 citations

Effect of indomethacin on basal and carbon dioxide stimulated cerebral blood flow in man

1981 • 71 citations

Prostaglandin-induced effects in the primate cerebral circulation

1977 • 71 citations

The Relation Between Cerebral Oxygen Consumption and Cerebral Vascular Reactivity to Carbon Dioxide

1971 • 68 citations

Effect of exogenous noradrenaline on local cerebral blood flow after osmotic opening of the blood‐brain barrier in the rat.

1978 • 66 citations

Endogenous Prostaglandin Release Contributes Directly to Coronary Artery Tone

1975 • 66 citations

The effect of hypoxia on prostaglandin output and on tone in isolated coronary arteries

1977 • 64 citations

Responsiveness to potassium and calcium ions of isolated cerebral arteries

1974 • 64 citations

Metabolism of prostaglandin E1 in the cerebral cortex and cerebellum of the dog and rat

1972 • 64 citations

A dissociation between fever and prostaglandin concentration in cerebrospinal fluid.

1975 • 63 citations

Prostacyclin in the cardiovascular system.

1980 • 62 citations

The effects of carbon dioxide on the entry and accumulation of drugs in the central nervous system.

1961 • 62 citations

Cellular Mechanisms of Prostaglandin Action

1979 • 57 citations

Unified Account of the Variable Effects of Carbon Dioxide on Nerve Cells

1970 • 56 citations

Electroconvulsive shock raises prostaglandins F in rat cerebral cortex

1975 • 55 citations

Late effects of subarachnoid haemorrhage on the response of the primate cerebral circulation to drug-induced changes in arterial blood pressure

1979 • 53 citations

Platelet Aggregation in Experimental Spinal Cord Injury

1979 • 53 citations

Indomethacin and inhibition of protein kinase reactions

1980 • 50 citations

Levels and disappearance of prostaglandin F2alpha in cerebral spinal fluid: a clinical and experimental study.

1977 • 50 citations

Vasoconstrictor effect of angiotensin on pial arteries.

1978 • 50 citations

Blood platelets do not provide endoperoxides for vascular prostacyclin production

1979 • 50 citations

Local Cerebral Blood Flow Values as Estimated with Diffusible Tracers: Validity of Assumptions in Normal and Ischemic Tissue

1981 • 49 citations

The interaction of pH and divalent cations at the neuromuscular junction.

1975 • 47 citations

Effects of prostaglandins on the internal and external carotid blood flow in the monkey

1974 • 47 citations

Responses of isolated dog cerebral and peripheral arteries to prostaglandins after application of aspirin and polyphloretin phosphate.

1978 • 47 citations

Prostaglandins as Mediators of Reactive Hyperaemia in Kidney

1974 • 47 citations

Effects of anti-inflammatory agents and some other drugs on prostaglandin biotransport.

1976 • 47 citations

Cerebrovascular response during and following severe insulin‐induced hypoglycemia: CO₂‐sensitivity, autoregulation, and influence of prostaglandin synthesis inhibition

1981 • 47 citations

The distribution of tritium‐labelled prostaglandin E₁ injected in amounts sufficient to produce central nervous effects in cats and chicks

1968 • 45 citations

Prostaglandins and renal function II. The effect of prostaglandin inhibition on autoregulation of blood flow in the intact kidney of the dog

1975 • 44 citations

5-Hydroxytryptamine accumulation in cerebrovascular injury

1974 • 44 citations

Effects of prostaglandins E1, E2, A1, A2, and F2α on canine carotid arterial blood flow, cerebrospinal fluid pressure, and intraocular pressure

1973 • 44 citations

Effects of prostaglandin E1 on experimental cerebral vasospasm

1972 • 43 citations

Responses of baboon cerebral and extracerebral arteries to prostacyclin and prostaglandin endoperoxide in vitro and in vivo.

1979 • 42 citations

Effects of angiotensin II on cerebral blood vessels

1979 • 42 citations

Determination of prostaglandin F2α, E2, D2 and 6-keto-F1α in human cerebrospinal fluid

1979 • 41 citations

Effect of Non-narcotic Analgesics on Membrane Permeability of Molluscan Neurones

1972 • 41 citations

Prostaglandins and potassium relaxation in vascular smooth muscle of the rat. The role of Na-K ATPase.

1980 • 40 citations

Unimportance of perivascular H+ and K+ activities for the adjustment of pial arterial diameter during changes of arterial blood pressure in cats

1979 • 40 citations

Prostaglandins and thromboxanes: biochemical and physiological considerations.

1978 • 39 citations

Pharmacological comparison of prostaglandin F2α, serotonin and norepinephrine on cerebrovascular tone of monkey

1971 • 39 citations

Measurement of prostaglandin E2 in cerebrospinal fluid in patients suffering from stroke.

1977 • 38 citations

Osmotic opening of the blood-brain barrier: value in pharmacological studies on the cerebral circulation

1977 • 38 citations

Inhibitors of prostaglandin catabolism. I. Differential sensitivity of 9-PGDH, 13-PGR and 15-PGDH to low concentrations of indomethacin

1975 • 37 citations

The effect of local changes in potassium and bicarbonate concentration on hypothalamic blood flow in the rabbit.

1976 • 36 citations

Prostaglandin release from the human umbilical artery in vitro

1973 • 35 citations

Potassium-induced relaxation in isolated cerebral arteries contracted with prostaglandin F2?

1976 • 35 citations

PROSTACYCLIN‐DEPENDENT ACTIVATION OF ADENYLATE CYCLASE IN A NEURONAL SOMATIC CELL HYBRID: PROSTANOID STRUCTURE‐ACTIVITY RELATIONSHIPS

1980 • 34 citations

MAINTENANCE OF IONIC COMPOSITION

1979 • 33 citations

Effects of Indomethacin on Cerebral Blood Flow and Oxygen Consumption in Barbiturate-Anesthetized Normocapnic and Hypercapnic Rats

1981 • 33 citations

Inhibition of functional vasodilatation and prostaglandin formation in rabbit adipose tissue by indomethacin and aspirin

1973 • 32 citations

The effect of potassium on nicotine-induced contracture and Ca45 movements in frog sartorius muscle.

1966 • 31 citations

Some Further Studies on Vasogenic Edema

1976 • 31 citations

Local cerebral blood flow in the brain during bicuculline‐induced seizures and the modulating influence of inhibition of prostaglandin synthesis

1981 • 30 citations

Cerebral blood flow in rats during physiological and humoral stimuli.

1981 • 30 citations

Cerebral Vasospasm

1980 • 28 citations

CATABOLISM OF PROSTAGLANDIN ENDOPEROXIDES INTO PROSTAGLANDIN E₂ AND F_2x BY THE RAT BRAIN

1976 • 28 citations

Constriction of Pial Arterioles Produced by Prostaglandin F _2α

1975 • 27 citations

Topical prostacyclin (PGI2) inhibits platelet aggregation in pial venules of the mouse.

1979 • 27 citations

Spasmogenic qualities of prostaglandin F2α in the cat

1976 • 26 citations

Prostaglandins and the cerebral circulation.

1983 • 26 citations

Roles of hypercapnia and acidosis in the vasodilator response to hypercapnic acidosis

1968 • 25 citations

The effects of isoprenaline and tyramine on the 45calcium uptake, the total calcium content and the contraction force of isolated guinea-pig atria in dependence on different extracellular hydrogen ion concentrations

1972 • 25 citations

Local effect of prostaglandins on cat pial arteries

1974 • 25 citations

Effect of intracarotid prostaglandin E1 on regional cerebral blood flow in man.

1976 • 24 citations

Termination of migraine headache by a new anti‐inflammatory vasoconstrictor agent

1965 • 21 citations

Prostacyclic production in rabbit arteries in situ: Inhibition by arachidonic acid-induced endothelial cell damage or by low-dose aspirin

1981 • 21 citations

Comparative effects of chloralose anesthesia and Sernylan analgesia on cerebral blood flow, CO2 responsiveness, and brain metabolism in the baboon.

1977 • 20 citations

The effect of indomethacin on autoregulation of renal blood flow in the anasthetized dog.

1977 • 19 citations

Assay methods for prostaglandins and thromboxanes.

1980 • 18 citations

Pial Arterial Response to Systemic Hypoxia in Anaesthetised Cats

1981 • 18 citations

The effect of salicylate on cerebral blood flow in man.

1977 • 17 citations

Role of Platelets in Vasogenic Brain Edema

1981 • 17 citations

Platelet Aggregation in the Pathogenesis of Cerebrovascular Disorders

1977 • 15 citations

The effects of CO2 and pH on the spontaneous activity of the taenia coli of guinea-pig

1972 • 15 citations

The Role of Humoral Agents Released by Platelet Aggregation in the Pathogenesis of Transient Ischemic Attacks

1978 • 13 citations

H+, CO2, Prostaglandins and Cerebrovascular Smooth Muscle

1976 • 13 citations

THE EFFECT OF SODIUM SALICYLATE ON CEREBRAL BLOOD FLOW AND METABOLISM

1980 • 12 citations

Interactions of Ionic Mechanisms in the Regulation of the Resistance of Pial Vessels

1975 • 12 citations

Some facts and thoughts on the biosynthesis of prostaglandins and thromboxanes in brain.

1978 • 11 citations

Effects of cerebral ventricular, systemic, and local administration of prostaglandin F2a on canine cerebral hemodynamics

1974 • 11 citations

Role of protein binding and pharmacokinetics in the lack of correlation between inhibition of PG-synthetase and antinflammatory activity of a homologous series of nonsteroidal antinflammatory compounds

1977 • 10 citations

Effect of SQ 80,338 (1-(3-phenyl-2-propenyl)-1H-imidazole) on thromboxane synthetase activity and arachidonic acid-induced platelet aggregation and bronchoconstriction.

1980 • 10 citations

Membrane Basis of Vascular Regulation

1976 • 9 citations

Prostaglandins and the Microvascular System: Physiological and Histochemical Correlations

1972 • 8 citations

5-methoxy-2-methyl-3-indole acetic acid, a metabolite and alkali hydrolysis product of indomethacin, inhibits pkateket aggregation, in vivo

1981 • 8 citations

Effect of Prostaglandin E&lt;sub&gt;1&lt;/sub&gt; on Cerebral Circulatory Disturbances

1972 • 8 citations

The Chemical Control of the Cerebral Circulation

1977 • 7 citations

Effects of Indomethacine and D 600 on the Smooth Muscles of Pial Vessels

1974 • 7 citations

Effect of intravenous indomethacin on cerebral clearance rate of inhaled xenon ¹³³

1968 • 6 citations

Measurement of prostaglandin F2α levels in cerebrospinal fluid of febrile and afebrile patients with advanced cancer

1977 • 5 citations

The plasma membrane sodium pump, PGE2 release, and acidic phospholipid turnover in the guinea pig taenia coli.

1980 • 3 citations

Effect of prostaglandins F2alpha and E1 on local tissue Po2 and microflow of the brain cortex (cat).

1980 • 2 citations