Synthesis of prostaglandins and thromboxane B2 by cerebral arteries.

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Drugs which inhibit prostaglandin biosynthesis.

1974 • 1,325 citations

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

1977 • 886 citations

Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium

1977 • 683 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

Cerebral arterial spasm

1974 • 390 citations

Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain

1977 • 232 citations

Cerebral arterial smooth muscle contraction by thromboxane A2.

1977 • 159 citations

Prostaglandins and the central nervous system.

1974 • 156 citations

Prostaglandin synthesis by bovine mesenteric arteries and veins.

1975 • 152 citations

Thromboxane A2 biosynthesis in the ureter obstructed isolated perfused kidney of the rabbit.

1978 • 146 citations

Blood vessel-hormone interactions: angiotensin, bradykinin, and prostaglandins

1977 • 134 citations

Endogenous formation of the prostaglandin endoperoxine metabolite, thromboxane B2, by brain tissue

1976 • 122 citations

Cerebral arterial spasm

1976 • 113 citations

The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system

1968 • 109 citations

Experimental Study on the Genesis of Cerebral Vasospasm

1975 • 104 citations

Role of prostaglandin F2a in the genesis of experimental cerebral vasospasm

1972 • 101 citations

THE DISCOVERY OF PROSTACYCLIN – – – A FRESH INSIGHT INTO ARACHIDONIC ACID METABOLISM

1977 • 77 citations

The effects of prostaglandins E1, A1, and F2a on the cerebral circulation of dogs and monkeys

1972 • 72 citations

Prostaglandin-induced effects in the primate cerebral circulation

1977 • 71 citations

The biosynthesis of prostaglandins by brain tissue in vitro.

1976 • 59 citations

Effects of prostaglandin synthesis inhibitors on angiotensin tachyphylaxis in the isolated coeliac and mesenteric arteries of the rabbit.

1974 • 58 citations

Biosynthesis of thromboxane B2: Assay, isolation, and properties of the enzyme system in human platelets

1976 • 54 citations

Levels and disappearance of prostaglandin F2alpha in cerebral spinal fluid: a clinical and experimental study.

1977 • 50 citations

Pharmacological comparison of prostaglandin F2α, serotonin and norepinephrine on cerebrovascular tone of monkey

1971 • 39 citations

Maintenance of the tone of the human umbilical artery by prostaglandin and thromboxane formation.

1976 • 36 citations

The synthesis of prostaglandins in human platelets.

1972 • 28 citations

Spasmogenic qualities of prostaglandin F2α in the cat

1976 • 26 citations

Local effect of prostaglandins on cat pial arteries

1974 • 25 citations

Effects of prostaglandins A1, E1, E2 and F2alpha on the basilar artery of cats.

1974 • 23 citations

Pleocytosis and elevation of prostaglandins F2a and E2 in cerebrospinal fluid following intracisternal injection of thrombin.

1977 • 22 citations

Effects of prostaglandins on cerebral blood vessels

1975 • 21 citations

Prostaglandins and cerebral vasospasm: a problem of interpretation.

1975 • 20 citations

Prostaglandins and experimental cerebral vasospasm.

1972 • 20 citations

Vasoactive properties of prostaglandin compounds on the in vitro human basilar artery.

1977 • 18 citations

THE STRUCTURE OF PROSTAGLANDIN I2

1977 • 9 citations

EXPERIMENTAL STROKE AND HEART ATTACK INDUCED BY THROMBOXANE A2 MIXTURE AND THEIR PREVENTION BY THROMBOXANE A2 ANTAGONISTIC SUBSTANCE, EG626

1977 • 4 citations