EFFECTS OF A SELECTIVE ENDOTHELIN A‐RECEPTOR ANTAGONIST, BQ‐123, IN SALT‐LOADED STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

1992 • 880 citations

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 • 737 citations

Establishment of the strokeprone spontaneously hypertensive rat (SHR)

1972 • 606 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

Endothelin is a potent mitogen for rat vascular smooth muscle cells

1989 • 509 citations

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.

1991 • 505 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Cardiac Hypertrophy in Spontaneously Hypertensive Rats

1974 • 458 citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

1989 • 413 citations

Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension.

1993 • 337 citations

Effects of endothelins on collagen turnover in cardiac fibroblasts

1993 • 290 citations

Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.

1994 • 252 citations

The effect of acute arterial hypertension on the blood-brain barrier to protein tracers

1970 • 224 citations

An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis

1991 • 192 citations

Potassium reduces cerebral hemorrhage and death rate in hypertensive rats, even when blood pressure is not lowered.

1985 • 158 citations

Endothelin-1 and Endothelin-3 Induce Chemotaxis and Replication of Pulmonary Artery Fibroblasts

1992 • 145 citations

Enalapril prevents stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats.

1989 • 143 citations

Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model

1993 • 123 citations

Relation of plasma renin to end organ damage and to protection of K+ feeding in stroke-prone hypertensive rats.

1990 • 123 citations

Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors

1989 • 98 citations

Potent selective vasoconstrictor effects of endothelin in the pig kidneyin vivo

1998 • 93 citations

Endothelin stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum‐free medium

1990 • 92 citations

A novel ET_A antagonist (BQ‐123) inhibits endothelin‐1‐induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells

1992 • 92 citations

Haemodynamic and renal tubular effects of low doses of endothelin in anaesthetized rats.

1991 • 80 citations

Contribution of Cardiovascular Factors to the Development of Hypertension in Spontaneously Hypertensive Rats

1974 • 64 citations

Renin-angiotensin system in stroke-prone spontaneously hypertensive rats

1979 • 62 citations

Endothelin Potentiates Growth Factor‐stimulated DNA Synthesis in Swiss 3T3 Cells

1989 • 52 citations

Thromboxane A2 in severe hypertension and stroke in stroke-prone spontaneously hypertensive rats.

1988 • 26 citations

Effects of endothelin on renal hemodynamics and tubuloglomerular feedback

1992 • 25 citations

Brain edema in acute arterial hypertension

1977 • 19 citations

Development of Hypertension and Life Span in Stroke-Prone Spontaneously Hypertensive Rats During Oral Long-Term Treatment with Various Antihypertensive Drugs

1989 • 19 citations

Permeability of intracranial extracerebral vessels in stroke-prone SHR.

1981 • 11 citations