Molecular Analysis of Homocysteic Acid-Induced Neuronal Stress

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

1996 • 8,994 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

14-3-3 Proteins: Structure, Function, and Regulation

2000 • 1,552 citations

Embryonic Stem Cells Express Neuronal Properties in Vitro

1995 • 1,173 citations

Calcium and oxidative stress: from cell signaling to cell death

2002 • 803 citations

Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro

1996 • 775 citations

14-3-3 proteins in the nervous system

2003 • 601 citations

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase‐related protein 2, α‐enolase and heat shock cognate 71

2002 • 579 citations

Molecular Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Cell Death

2001 • 532 citations

Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia

1993 • 475 citations

Stress management – heat shock protein-70 and the regulation of apoptosis

2001 • 428 citations

Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons

1992 • 421 citations

Twenty-five years of immobilized metal ion affinity chromatography: past, present and future

2001 • 344 citations

The b' domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins

1998 • 332 citations

Impaired Homocysteine Metabolism and Atherothrombotic Disease

2001 • 268 citations

Chronic heart failure and micronutrients

2001 • 247 citations

14-3-3ζ Is an Effector of Tau Protein Phosphorylation

2000 • 215 citations

Vitamin D and systemic cancer: is this relevant to malignant melanoma?

2002 • 199 citations

Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker

2002 • 196 citations

Structure Determination of the N-Terminal Thioredoxin-like Domain of Protein Disulfide Isomerase Using Multidimensional Heteronuclear ¹³C/¹⁵N NMR Spectroscopy

1996 • 194 citations

Gene expression on acute myocardial stress. Induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress

1995 • 188 citations

Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer.

1997 • 186 citations

14-3-3 α and δ Are the Phosphorylated Forms of Raf-activating 14-3-3 β and ζ

1995 • 181 citations

Integrating stress-response and cell-cycle checkpoint pathways

2001 • 167 citations

The unfolded protein response and Alzheimer’s disease

2001 • 145 citations

14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylation

2000 • 129 citations

Regulation of stress‐activated protein kinase signaling pathways by protein phosphatases

2002 • 102 citations

The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia

2000 • 90 citations

Phosphorylation of RTP, an ER Stress-Responsive Cytoplasmic Protein

2000 • 85 citations

The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia

2003 • 81 citations

Homocysteine-dependent Alterations in Mitochondrial Gene Expression, Function and Structure

1998 • 76 citations

14-3-3 Isotypes facilitate coupling of protein kinase C-ζ to Raf-1: negative regulation by 14-3-3 phosphorylation

2000 • 67 citations

Mild Hyperhomocysteinemia is an Independent Risk Factor of Arterial Vascular Disease

2000 • 64 citations

Oral administration of homocysteine leads to increased plasma triglycerides and homocysteic acid — additional mechanisms in homocysteine induced endothelial damage?

1995 • 63 citations

Untitled

2002 • 55 citations

The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21)

2003 • 53 citations

Protein abundance quantification in embryonic stem cells using incomplete metabolic labelling with ¹⁵N amino acids, matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry, and analysis of relative isotopologue abundances of peptides

2003 • 51 citations

Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures

2000 • 49 citations

Differential Activation of PKC Isozymes by 14-3-3 ζ Protein

1995 • 49 citations

Sequencing of peptides phosphorylated on serines and threonines by post-source decay in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

1999 • 48 citations

Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists

2001 • 44 citations

Analysis of relative isotopologue abundances for quantitative profiling of complex protein mixtures labelled with the acrylamide/D₃‐acrylamide alkylation tag system

2003 • 43 citations

Systematic screening of the 14-3-3 eta (?) chain gene for polymorphic variants and case-control analysis in schizophrenia

2000 • 43 citations

Proteasome-Dependent Turnover of Protein Disulfide Isomerase in Oxidatively Stressed Cells

2002 • 42 citations

Is homocysteine a pro-oxidant?

2001 • 42 citations

l-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients

2002 • 40 citations

Rho GTPases as therapeutic targets for the treatment of inflammatory diseases

2003 • 35 citations

DL -Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo

2002 • 34 citations

Evidence that protein disulfide isomerase (PDI) is involved in DNA–nuclear matrix anchoring

2002 • 22 citations

Homocysteine enhances the inhibitory effect of extracellular adenosine on the synthesis of proteins in isolated rat hepatocytes

1995 • 19 citations

Characterization of <scp>l</scp>-Homocysteate–Induced Currents in Purkinje Cells From Wild-Type and NMDA Receptor Knockout Mice

1999 • 19 citations