Metabolic activation and cytotoxicity of cyclophosphamide in primary cultures of postnatal rat hepatocytes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

BIOGENESIS OF ENDOPLASMIC RETICULUM MEMBRANES

1966 • 590 citations

Reviews in biochemical toxicology

1979 • 518 citations

Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.

1977 • 470 citations

Cytochrome P-450 and its Role in Drug Metabolism

1972 • 392 citations

Use of γ-(4-Nitrobenzyl)pyridine as Analytical Reagent for Ethylenimines and Alkylating Agents

1955 • 348 citations

Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide

1974 • 347 citations

Progress in drug metabolism

1977 • 309 citations

Metabolic Activation of Drugs to Toxic Substances

1975 • 281 citations

Advances in modern toxicology

1978 • 267 citations

Colorimetric Estimation of Nitrogen Mustards in Aqueous Media. Hydrolytic Behavior of Bis-(β-chloroethyl)amine, nor HN2

1961 • 244 citations

Drug Metabolism in Adult Rat Hepatocytes in Primary Monolayer Culture

1977 • 226 citations

Isolation and long-term cell culture of epithelial-like cells from rat liver

1971 • 211 citations

Alkylating properties of phosphoramide mustard.

1976 • 168 citations

Metabolism of cyclophosphamide by rat hepatic microsomes.

1971 • 157 citations

Drug metabolism as a cause of drug toxicity.

1973 • 133 citations

Isolation and mass spectral identification of blood metabolities of cyclophosphamide: Evidence for phosphoramide mustard as the biologically active metabolite

1975 • 124 citations

Hepatotoxicity studies with primary cultures of rat liver cells

1978 • 104 citations

A Study of Drug Metabolism Linked to Cytochrome P‐450 in Isolated Rat‐Liver Cells

1974 • 103 citations

The role of metabolism in chemical mutagenesis and chemical carcinogenesis

1980 • 102 citations

Kinetics of cyclophosphamide biotransformation in vivo.

1980 • 97 citations

An in vitro chromosome assay using cultured rat-liver cells

1979 • 95 citations

Activation of xenobiotics by monooxygenases: cultures of mammalian cells as analytical tool

1977 • 85 citations

Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver

1971 • 82 citations

Serum dependent growth of primary cultured differentiated fetal rat hepatocytes in arginine‐deficient medium

1973 • 68 citations

Cytotoxicity of acetaminophen and papaverine in primary cultures of rat hepatocytes

1980 • 67 citations

Effects of a hormone-supplemented medium on cytochrome P-450 content and mono-oxygenase activities of rat hepatocytes in primary culture

1980 • 66 citations

Primary monolayer cultures of postnatal rat liver cells with extended differentiated functions

1978 • 56 citations

Primary cultures of adult mouse and rat hepatocytes for studying the metabolism of foreign chemicals

1980 • 56 citations

Metabolism of drugs in rat liver during the perinatal period

1971 • 47 citations

A novel mixed hepatocyte-fibroblast culture system and its use as a test for metabolism-mediated cytotoxicity

1977 • 44 citations

Denaturation of cytochrome P-450 by cyclophosphamide metabolites

1978 • 37 citations

Organic compounds. Their interaction with and degradation of hepatic microsomal drug-metabolizing enzymes in vitro.

1978 • 35 citations

Comparison of cytochrome P-450 levels in adult rat liver, postnatal rat liver, and primary cultures of postnatal rat hepatocytes

1979 • 27 citations

Protection by N-acetylcysteine of cyclophosphamide metabolism - related invivo depression of mixed function oxygenase activity and invitro denaturation of cytochrome P-450

1980 • 25 citations

Metabolism-mediated cytotoxicity of chemical carcinogens and non-carcinogens

1978 • 21 citations

Clinical Cancer Chemotherapy

1976 • 16 citations

Ultrastructural Concepts of Drug Metabolism. I. The Hepatocyte: Structure and Function

1974 • 8 citations