Regulation of Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue: Tissue-Specific Induction by Cytokines*

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991

1994 • 2,623 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Increasing Prevalence of Overweight Among US Adults

1994 • 1,479 citations

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

1998 • 1,109 citations

Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss*

2000 • 1,011 citations

Does central obesity reflect “Cushing's disease of the omentum”?

1997 • 755 citations

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

1998 • 715 citations

Cortisol secretion in relation to body fat distribution in obese premenopausal women

1992 • 468 citations

Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor γ

1995 • 458 citations

Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss

2000 • 444 citations

Cortisol Metabolism in Human Obesity: Impaired Cortisone→Cortisol Conversion in Subjects with Central Adiposity¹

1999 • 406 citations

Understanding the Role of Glucocorticoids in Obesity: Tissue-Specific Alterations of Corticosterone Metabolism in Obese Zucker Rats1

2000 • 340 citations

Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells

1997 • 305 citations

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations.

1995 • 301 citations

Indinavir-associated lipodystrophy

1998 • 287 citations

Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells.

1986 • 280 citations

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

1997 • 277 citations

Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency

1993 • 260 citations

Differentiation of Adipose Stromal Cells: The Roles of Glucocorticoids and 11β-Hydroxysteroid Dehydrogenase*

1999 • 251 citations

Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects.

1995 • 242 citations

Obesity

1997 • 228 citations

Tumor Necrosis Factor α and Interleukin 1β Enhance the Cortisone/Cortisol Shuttle

1997 • 183 citations

Pseudo‐Cushing's Syndrome in Human Immunodeficiency Virus– Infected Patients

1998 • 176 citations

Modulation of 11β-Hydroxysteroid Dehydrogenase Isozymes by Growth Hormone and Insulin-Like Growth Factor: In Vivo and In Vitro Studies1

1999 • 158 citations

Tumor necrosis factor-alpha prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells.

1993 • 146 citations

Recent advances in the molecular basis of TNF signal transduction.

1999 • 131 citations

The effect of growth hormone replacement therapy on cortisol-cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11beta-hydroxysteroid dehydrogenase activity

1998 • 125 citations

Variation Among Cell Types in the Signaling Pathways by which IGF-I Stimulates Specific Cellular Responses*

1999 • 122 citations

11β-hydroxysteroid dehydrogenase 1 in adipocytes: Expression is differentiation-dependent and hormonally regulated

1998 • 119 citations

Sexual dimorphism of hepatic 11β-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns

1994 • 112 citations

Human 11β-hydroxysteroid dehydrogenase: Studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue

1997 • 100 citations

Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes

1998 • 79 citations

Upper-body fat distribution: a hyperinsulinemia-independent predictor of coronary heart disease mortality. The Paris Prospective Study.

1992 • 76 citations

Long-Term Follow-Up of Hypopituitary Patients Treated with Human Growth Hormone

1990 • 62 citations

Body fat distribution and coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes mellitus: the Paris Prospective Study, 15-year follow-up

1992 • 56 citations

The effect of growth hormone replacement therapy on cortisol-cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11beta-hydroxysteroid dehydrogenase activity

1998 • 51 citations

Effect of growth hormone, insulin and dexamethasone on 11 β -hydroxysteroid dehydrogenase activity on a primary culture of rat hepatocytes

1996 • 48 citations

15-deoxy-Δ12,14 prostaglandin J2: A putative endogenous promoter of adipogenesis suppresses the ob gene

1999 • 45 citations

Insulin attenuates the stimulatory effects of tumor necrosis factor α on 11β-hydroxysteroid dehydrogenase 1 in human adipose stromal cells

2000 • 44 citations

Increased Soft Tissue in the Posterior Cervical and Upper Back Area of Patients on HIV-1 Protease Inhibitors

1999 • 8 citations