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Stochastic Problems in Physics and Astronomy

1943 • 8,251 citations

Oncogenic kinase signalling

2001 • 3,632 citations

Epidermal growth factor receptor: mechanisms of activation and signalling

2003 • 1,514 citations

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains

2002 • 1,158 citations

Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor

2002 • 972 citations

An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

2003 • 873 citations

EGF Activates Its Receptor by Removing Interactions that Autoinhibit Ectodomain Dimerization

2003 • 764 citations

Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α

2002 • 751 citations

Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether

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1986 • 381 citations

Two EGF molecules contribute additively to stabilization of the EGFR dimer

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The epidermal growth factor receptor as a multifunctional allosteric protein

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A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

1986 • 222 citations

Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

1989 • 197 citations

The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function

2004 • 104 citations

Identification of a Determinant of Epidermal Growth Factor Receptor Ligand-Binding Specificity Using a Truncated, High-Affinity Form of the Ectodomain

2001 • 89 citations

A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor.

1993 • 50 citations

Interpretation of Scatchard plots for aggregating receptor systems

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Identification of an intracellular domain of the EGF receptor required for high‐affinity binding of EGF

1997 • 21 citations

Thermodynamic mixing of molecular states of the epidermal growth factor receptor modulates macroscopic ligand binding affinity

2000 • 16 citations