Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Textbook of pain

1999 • 2,566 citations

Evidence for a central component of post-injury pain hypersensitivity

1983 • 2,103 citations

Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

1991 • 1,760 citations

Gabapentin for the Symptomatic Treatment of Painful Neuropathy in Patients With Diabetes Mellitus<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1998 • 1,544 citations

Gabapentin for the Treatment of Postherpetic Neuralgia<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1998 • 1,461 citations

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel

1996 • 1,164 citations

Peripheral nerve injury triggers central sprouting of myelinated afferents

1992 • 1,073 citations

Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.

1992 • 785 citations

Painful neuropathy: altered central processing maintained dynamically by peripheral input

1992 • 770 citations

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists

1989 • 671 citations

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

1991 • 616 citations

Auxiliary subunits of voltage-gated ion channels

1994 • 561 citations

Dynamic and static components of mechanical hyperalgesia in human hairy skin

1992 • 510 citations

Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain

1994 • 469 citations

Molecular Basis for CA2+ Channel Diversity

1994 • 461 citations

Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents

1997 • 329 citations

The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain

1997 • 317 citations

Gabapentin Adjunctive Therapy in Neuropathic Pain States

1996 • 309 citations

Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat

1999 • 292 citations

Mechanisms of touch-evoked pain (allodynia): a new model

1996 • 283 citations

Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn

1986 • 273 citations

Mechanical hyperalgesias in neuropathic pain patients: Dynamic and static subtypes

1993 • 256 citations

Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain.

1997 • 246 citations

The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed byd-serine

1996 • 234 citations

A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats

1990 • 221 citations

The Effect of Gabapentin on Neuropathic Pain

1997 • 217 citations

Gabapentin inhibits calcium currents in isolated rat brain neurons

1998 • 204 citations

Reflex sympathetic dystrophy treated with gabapentin

1997 • 204 citations

Capsaicin and pain mechanisms

1995 • 203 citations

Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain

1991 • 191 citations

Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats

1995 • 180 citations

Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model

1995 • 179 citations

Effect of subarachnoid gabapentin on tactile-evoked allodynia in a surgically induced neuropathic pain model in the rat‡§

1997 • 172 citations

Characterization of the Effects of Gabapentin and 3-Isobutyl-γ-Aminobutyric Acid on Substance P-induced Thermal Hyperalgesia

1998 • 147 citations

Gabapentin for the Treatment of Postherpetic Neuralgia

1999 • 133 citations

Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat?

1993 • 127 citations

Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation

1997 • 121 citations

Gabapentin for idiopathic trigeminal neuralgia

1997 • 119 citations

Spinal gabapentin is antinociceptive in the rat formalin test

1997 • 116 citations

Evolution: The causes of mass extinctions

1984 • 114 citations

Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats

1997 • 108 citations

Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat

1994 • 100 citations

Time course of degeneration and regeneration of myelinated nerve fibres following chronic loose ligatures of the rat sciatic nerve: can nerve lesions be linked to the abnormal pain-related behaviours?

1993 • 91 citations

Erythromelalgia Pain Managed with Gabapentin

1997 • 88 citations

Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve

1994 • 81 citations

Differential action of morphine and various opioid agonists on thermal allodynia and hyperalgesia in mononeuropathic rats

1994 • 74 citations

Further evidence for myelinated as well as unmyelinated fibre damage in a rat model of neuropathic pain

1992 • 65 citations

The depressive effect of morphine on the C fibre response of dorsal horn neurones in the spinal rat pretreated or not by pCPA

1979 • 61 citations

Pain characterization in cancer patients and the analgetic response to epidural morphine

1991 • 59 citations

Sprouting of A‐fibre primary afferents into lamina II in two rat models of neuropathic pain

1997 • 53 citations

Modern Concepts of Pain and Hyperalgesia: Beyond the Polymodal C-Nociceptor

1995 • 48 citations

Neonatal capsaicin treatment prevents the development of the thermal hyperalgesia produced in a model of neuropathic pain in the rat

1992 • 46 citations

Painful Neuropathy

1995 • 23 citations

A case of ‘pure’ dynamic mechano-allodynia due to a lesion of the spinal cord: pathophysiological considerations

1998 • 16 citations

Dynamic mechanical allodynia is not mediated by a central presynaptic interaction of aβ-mechanoceptive and nociceptive c-afferents

1998 • 3 citations