Transcription Activation of Mouse Mammary Tumor Virus-Chloramphenicol Acetyltransferase: A Model To Study the Metabolism of Cortisol

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

1988 • 1,047 citations

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

1984 • 891 citations

The neuronal mineralocorticoid eeceptor as a mediator of glucocorticoid response

1988 • 576 citations

Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.

1983 • 515 citations

A Syndrome of Apparent Mineralocorticoid Excess Associated with Defects in the Peripheral Metabolism of Cortisol*

1979 • 490 citations

Cloning and Expression of Rat cDNA Encoding Corticosteroid 11β-Dehydrogenase

1989 • 452 citations

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

1991 • 434 citations

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.

1988 • 420 citations

Licorice Inhibits Corticosteroid 1lβ-Dehydrogenase of Rat Kidney and Liver:In Vivoandin VitroStudies*

1989 • 306 citations

Ontogeny of cortisol-cortisone interconversion in human tissues: A role for cortisone in human fetal development

1981 • 178 citations

Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action.

1993 • 158 citations

11β-Hydroxysteroid dehydrogenase: Fact or fancy?

1984 • 129 citations

Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver

1968 • 105 citations

CONGENITAL 11β‐HYDROXYSTEROID DEHYDROGENASE DEFICIENCY ASSOCIATED WITH JUVENILE HYPERTENSION: CORTICOSTEROID METABOLITE PROFILES OF FOUR PATIENTS AND THEIR FAMILIES

1985 • 102 citations

Apparent mineralocorticoid excess, pseudohypoaldosteronism, and urinary electrolyte excretion: toward a redefinition of mineralocorticoid action

1990 • 100 citations

The effects of the licorice derivative, glycyrrhetinic acid, on hepatic 3α- and 3β-hydroxysteroid dehydrogenases and 5α- and 5β-reductase pathways of metabolism of aldosterone in male rats

1990 • 96 citations

Evidence for Independent 11-Oxidase and 11-Reductase Activities of 1 lβ-Hydroxysteroid Dehydrogenase: Enzyme Latency, Phase Transitions, and Lipid Requirements*

1985 • 90 citations

Characterization of 11 β-Hydroxysteroid Dehydrogenase Gene Expression: Identification of Multiple Unique Forms of Messenger Ribonucleic Acid in the Rat Kidney

1990 • 85 citations

Cloning of the human glucocorticoid receptor cDNA

1985 • 79 citations

A new defect in the peripheral conversion of cortisone to cortisol

1985 • 79 citations

Evidence for kinetically distinct forms of corticosteroid 11β-dehydrogenase in rat liver microsomes

1989 • 78 citations

Equivalent affinity of aldosterone and corticosterone for type I receptors in kidney and hippocampus: Direct binding studies

1987 • 73 citations

Glucocorticoid metabolism in human placenta, decidua, myometrium and fetal membranes

1982 • 70 citations

High Affinity Binding and Regulatory Actions of Dexamethasone-Type I Receptor Complexes in Mouse Brain*

1989 • 55 citations

Cortisol Production and Inactivation by the Human Lung during Gestation and Infancy*

1978 • 50 citations

Extraction of 11β-hydroxysteroid dehydrogenase from rat liver microsomes by detergents

1985 • 49 citations

Ontogeny of 11 beta-hydroxysteroid dehydrogenase in rat brain and kidney.

1992 • 45 citations

Nuclear localization of aldosterone in rat brain cells assessed by autoradiography

1979 • 45 citations

Specific Region in Hormone Binding Domain Is Essential for Hormone Binding and Trans-Activation by Human Androgen Receptor

1990 • 40 citations

Cortisol-Cortisone Interconversion in Human Fetal Lung: Contrasting Results Using Explant and Monolayer Cultures Suggest That llβ-Hydroxysteroid Dehydrogenase (EC 1.1.1.146) Comprises Two Enzymes

1982 • 39 citations

APPARENT MINERALOCORTICOID EXCESS AND DEFICIENT 11β‐OXIDATION OF CORTISOL IN A YOUNG FEMALE

1984 • 35 citations

Chemical differentiation of Type I and Type II receptors for adrenal steroids in brain cytosol

1986 • 34 citations

Purification of a human glucocorticoid receptor gene promoter-binding protein. Production of polyclonal antibodies against the purified factor

1991 • 28 citations

ORGAN-SPECIFIC ONTOGENESES OF STEROID HORMONE METABOLIZING ENZYME ACTIVITIES IN THE RAT

1975 • 22 citations

11β-Hydroxysteroid dehydrogenase and tissue specificity of androgen action in human prostate cancer cell LNCaP

1994 • 22 citations

Differential regulation of mouse mammary tumor virus-bacterial chloramphenicol acetyltranferase chimeric gene by human mineralocorticoid hormone-receptor complexes

1991 • 20 citations

Epithelial and adipose cells isolated from mammary glands of pregnant and lactating rats differ in 11β-hydroxysteroid dehydrogenase activity

1990 • 19 citations

11β-Hydroxysteroid dehydrogenase in renal collecting duct cells

1994 • 18 citations