Phosphorylation of Isolated Human Phosphodiesterase-5 Regulatory Domain Induces an Apparent Conformational Change and Increases cGMP Binding Affinity

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

2000 • 739 citations

The GAF domain: an evolutionary link between diverse phototransducing proteins

1997 • 572 citations

Energetics of Ligand Binding to Proteins

1975 • 519 citations

Stimulation of Adenosine 3',5'-Monophosphate Hydrolysis by Guanosine 3',5'-Monophosphate

1971 • 275 citations

Phosphorylation of phosphodiesterase‐5 by cyclic nucleotide‐dependent protein kinase alters its catalytic and allosteric cGMP‐binding activities

2000 • 273 citations

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

1990 • 232 citations

Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase

1998 • 221 citations

Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells

2002 • 216 citations

Characterization of a novel cGMP binding protein from rat lung.

1980 • 179 citations

Cyclic nucleotide phosphodiesterases: Structure, regulation and drug action

1991 • 176 citations

Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases.

1990 • 174 citations

The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone.

1993 • 169 citations

Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.

1990 • 161 citations

Cyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase.

1980 • 141 citations

Rapid nitric oxide–induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme

2001 • 130 citations

Cyclic nucleotide phosphodiesterases : structure, regulation and drug action

1990 • 112 citations

An Essential Aspartic Acid at Each of Two Allosteric cGMP-binding Sites of a cGMP-specific Phosphodiesterase

1995 • 96 citations

Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation

1998 • 89 citations

Brain Receptor Methodologies

1984 • 73 citations

Structure and function studies of the cGMP-stimulated phosphodiesterase.

1991 • 73 citations

Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase

2002 • 54 citations

Ligand-Induced Conformational Changes in Cyclic Nucleotide Phosphodiesterases and Cyclic Nucleotide-Dependent Protein Kinases

1998 • 34 citations

2 From phosphorylase to phosphorylase kinase

1997 • 8 citations