Class switch from μ to δ is mediated by homologous recombination between σ_μ and σ_μ sequences in human immunoglobulin gene loci

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

The Chromosomal Basis of Human Neoplasia

1983 • 1,121 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 • 297 citations

The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes

1981 • 260 citations

Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon

1985 • 232 citations

Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes

1981 • 219 citations

Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms

1981 • 143 citations

Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant.

1984 • 127 citations

DNase I hypersensitive sites in the chromatin of human μ immunoglobulin heavy-chain genes

1983 • 110 citations

Unusual sequences in the murine immunoglobulin μ–δ heavy-chain region

1983 • 108 citations

Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.

1981 • 99 citations

Directed Ig class switch recombination in activated murine B cells.

1987 • 94 citations

Switch from hapten-specific immunoglobulin M to immunoglobulin D secretion in a hybrid mouse cell line.

1981 • 78 citations

Control of Immunoglobulin Class Switch Recombination

1986 • 60 citations

The sequence of the human immunoglobulin μ-δ intron reveals possible vestigial switch segments

1984 • 60 citations

Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.

1987 • 59 citations

Looping out and deletion mechanism for the immunoglobulin heavy-chain class switch.

1988 • 57 citations

Role of IgD and Tδ Cells in the Regulation of the Humoral Immune Response

1988 • 51 citations

The Structure and Biology of Human IgD

1977 • 49 citations

Illegitimate recombination generates a class switch from C mu to C delta in an IgD-secreting plasmacytoma.

1984 • 36 citations

Lymphocyte Membrane IgD

1977 • 34 citations

Allotypes of IgM and IgD Receptors in the Mouse: A Probe for Lymphocyte Differentiation

1978 • 29 citations

Sigma region located between C, and C, genes of human immunoglobulin heavy chain: possible involvement of tRNA-like structure in RNA splicing

1988 • 22 citations