Phenotypic Mechanism of HIV-1 Resistance to 3‘-Azido-3‘-deoxythymidine (AZT): Increased Polymerization Processivity and Enhanced Sensitivity to Pyrophosphate of the Mutant Viral Reverse Transcriptase

Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase

1994 • 512 citations

Production of single-stranded DNA templates by exonuclease digestion following the polymerase chain reaction

1989 • 342 citations

Mechanism of action of foscarnet against viral polymerases

1992 • 189 citations

Studies on the mechanism of human immunodeficiency virus reverse transcriptase. Steady-state kinetics, processivity, and polynucleotide inhibition.

1988 • 167 citations

Prevalence and Clinical Significance of Zidovudine Resistance Mutations in Human Immunodeficiency Virus Isolated from Patients after Long-Term Zidovudine Treatment

1995 • 141 citations

Catalytic properties of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2.

1991 • 124 citations

Reduced Frameshift Fidelity and Processivity of HIV-1 Reverse Transcriptase Mutants Containing Alanine Substitutions in Helix H of the Thumb Subdomain

1995 • 121 citations

Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain.

1994 • 106 citations

Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication

1996 • 94 citations

Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet

1996 • 71 citations

Single-Step Purification of Recombinant Wild-Type and Mutant HIV-1 Reverse Transcriptase

1996 • 67 citations

Site-directed Mutagenesis of Arginine 72 of HIV-1 Reverse Transcriptase

1995 • 66 citations

The K65R Mutation Confers Increased DNA Polymerase Processivity to HIV-1 Reverse Transcriptase

1996 • 55 citations

Enhanced Binding of Azidothymidine-resistant Human Immunodeficiency Virus 1 Reverse Transcriptase to the 3′-Azido-3′-deoxythymidine 5′-Monophosphate-terminated Primer

1998 • 55 citations

Characterisation of Foscarnet-Resistant Strains of Human Immunodeficiency Virus Type 1

1995 • 39 citations

Developmental pharmacology and toxicology of anti‐HIV therapeutic agents: dideoxynucleosides ¹

1995 • 33 citations

Mutagenic study of codons 74 and 215 of the human immunodeficiency virus type 1 reverse transcriptase, which are significant in nucleoside analog resistance

1994 • 33 citations

Analysis of HIV-2 RT mutants provides evidence that resistance of HIV-1 RT and HIV-2 RT to nucleoside analogs involves a repositioning of the template-primer

1997 • 23 citations

The time of administration of 3'-azido-3'-deoxythymidine (AZT) determines its host toxicity with possible relevance to AZT chemotherapy

1993 • 17 citations