Rapid Activation of Tyrosine Hydroxylase in Response to Nerve Growth Factor

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Tyrosine Hydroxylase

1964 • 2,038 citations

Nerve growth factor.

1968 • 2,025 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

PC12 Pheochromocytoma Cultures in Neurobiological Research

1982 • 728 citations

Characterization and isolation of proteolytically modified nerve growth factor

1976 • 677 citations

A rapid and simple radioassay for tyrosine hydroxylase activity

1964 • 506 citations

Non-Inverted Versus Inverted Plots in Enzyme Kinetics

1959 • 463 citations

Selective Induction by Nerve Growth Factor of Tyrosine Hydroxylase and Dopamine-β-Hydroxylase in the Rat Superior Cervical Ganglia

1971 • 308 citations

Nerve growth factor mediates phosphorylation of specific proteins

1980 • 305 citations

Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell line.

1980 • 292 citations

Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.

1978 • 286 citations

Alterations in the surface properties of cells responsive to nerve growth factor

1978 • 279 citations

Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states.

1980 • 255 citations

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

1981 • 234 citations

STRUCTURAL BASIS FOR INHIBITION OF PROTEIN SYNTHESIS BY EMETINE AND CYCLOHEXIMIDE BASED ON AN ANALOGY BETWEEN IPECAC ALKALOIDS AND GLUTARIMIDE ANTIBIOTICS

1966 • 223 citations

Role of nerve growth factor in the development of rat sympathetic neurons in vitro. I. Survival, growth, and differentiation of catecholamine production.

1977 • 218 citations

Regulation of a high molecular weight microtubule-associated protein in PC12 cells by nerve growth factor.

1983 • 207 citations

Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase.

1980 • 189 citations

Binding of Nerve Growth Factor Receptor in Sympathetic Ganglia

1973 • 180 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the cAMP-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 177 citations

The regulation of norepinephrine synthesis in sympathetic nerves: effect of nerve stimulation, cocaine, and catecholamine-releasing agents.

1966 • 164 citations

Regulation of catecholamine synthesis in the rat brain in vitro by cyclic AMP

1974 • 161 citations

Rapid, sequential changes in surface morphology of PC12 pheochromocytoma cells in response to nerve growth factor

1979 • 146 citations

Increased phosphorylation of specific nuclear proteins in superior cervical ganglia and PC12 cells in response to nerve growth factor.

1980 • 132 citations

Induction of tyrosine hydroxylase by nerve growth factor and by elevated K+ concentrations in cultures of dissociated sympathetic neurons

1982 • 129 citations

alpha-Adrenergic regulation of secretion of mouse saliva rich in nerve growth factor.

1976 • 111 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the acetylcholine-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 106 citations

Multiple site phosphorylation of tyrosine hydroxylase. Differential regulation in situ by a 8-bromo-cAMP and acetylcholine.

1982 • 100 citations

Regulation of bovine adrenal tyrosine 3-monooxygenase by phosphorylation-dephosphorylation reaction, catalyzed by adenosine 3‘:5‘-monophosphate-dependent protein kinase and phosphoprotein phosphatase.

1979 • 83 citations

Rapid stimulation by nerve growth factor of amino acid uptake by clonal PC12 pheochromocytoma cells.

1979 • 79 citations

SHORT‐TERM REGULATION OF CATECHOLAMINE BIOSYNTHESIS IN A NERVE GROWTH FACTOR RESPONSIVE CLONAL LINE OF RAT PHEOCHROMOCYTOMA CELLS

1978 • 79 citations

Soluble, Membrane-bound, and Detergent-solubilized Rat Striatal Tyrosine Hydroxylase

1973 • 62 citations

Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase.

1981 • 61 citations

Studies on phenylalanine and tyrosine hydroxylation by rat brain tyrosine hydroxylase

1976 • 61 citations

Tyrosine Hydroxylase from Bovine Striatum: Catalytic Properties of the Phosphorylated and Nonphosphorylated Forms of the Purified Enzyme

1982 • 57 citations

Effect of dibutyryl cyclic adenosine monophosphate on 14C-dopamine biosynthesis in rat brain striatal slices.

1974 • 52 citations

Biosynthesis of the sympathetic neurotransmitter, norepinephrine.

1966 • 47 citations

Immunochemical properties of the nerve growth factor.

1968 • 41 citations

Differences in sensitivity to nerve growth factor of axon formation and tyrosine hydroxylase induction in cultured sympathetic neurons

1976 • 40 citations

Potassium-induced acceleration of catecholamine biosynthesis in brain slices. I. A study of the mechanism of action.

1971 • 35 citations

Tyrosine 3-monooxygenase regulates catecholamine synthesis in pheochromocytoma cells.

1980 • 34 citations

The biosynthesis of phosphorylated tyrosine hydroxylase by organ cultures of rat adrenal medulla and superior cervical ganglia: A correction

1977 • 11 citations

TYROSINE HYDROXYLASE FROM BRAIN: PHOSPHORYLATION OF THE ENZYME BY CYCLIC AMP-DEPENDENT PROTEIN KINASE

1979 • 10 citations