Soluble polymers for lectin-mediated drug targeting

Structure and properties of pharmacologically active polymers

1975 • 1,069 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

2001 • 644 citations

Tumoritropic and lymphotropic principles of macromolecular drugs.

1989 • 576 citations

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo

1992 • 548 citations

Drug-polymer conjugates

1992 • 441 citations

Effect of molecular weight (M_w) ofN‐(2‐hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats

1987 • 428 citations

The uses and properties of PEG-linked proteins.

1992 • 425 citations

Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.

1982 • 357 citations

Passive tumor targeting of soluble macromolecules and drug conjugates.

1992 • 315 citations

A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain

1992 • 290 citations

Uptake of neoglycoproteins via membrane lectin(s) of L1210 cells evidenced by quantitative flow cytofluorometry and drug targeting

1984 • 222 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

1991 • 209 citations

Polyvinyl Pyrrolidone as a Plasma Expander

1952 • 192 citations

Preclinical evaluation of polymer-bound doxorubicin

1992 • 189 citations

Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma

1984 • 163 citations

Binding of N-linked bovine fetuin glycopeptides to isolated rabbit hepatocytes: Gal/GalNAc hepatic lectin discrimination between Gal.beta.(1,4)GlcNAc and Gal.beta.(1,3)GlcNAc in a triantennary structure

1986 • 146 citations

Block copolymers as drug carriers.

1992 • 140 citations

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats

1986 • 133 citations

Targeting of N-(2-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues

1983 • 128 citations

Adherence of Shigella flexneri to guinea pig intestinal cells is mediated by a mucosal adhesion

1982 • 124 citations

Turnover of the surface proteins and the receptor for serum asialoglycoproteins in primary cultures of rat hepatocytes.

1981 • 122 citations

Hepatic tissue distribution of doxorubicin-loaded nanoparticles after i.v. administration in reticulosarcoma M 5076 metastasis-bearing mice

1990 • 121 citations

Recognition of complex oligosaccharides by the multi-subunit asialoglycoprotein receptor

1991 • 120 citations

N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice

1991 • 116 citations

Doxorubicin-Loaded Nanoparticles: Increased Efficiency in Murine Hepatic Metastases

1989 • 102 citations

Advances in Biomedical Polymers

1987 • 95 citations

Polymers containing enzymatically degradable bonds, XII. Effect of spacer structure on the rate of release of daunomycin and adriamycin from poly [N-(2-hydroxypropyl)-methacrylamide] copolymer drag carriers in vitro and antitumour activity measured in vivo

1992 • 95 citations

Abnormal surface distribution of the human asialoglycoprotein receptor in cirrhosis

1992 • 87 citations

The role of extra-hepatic tissues in the receptor-mediated plasma clearance of glycoproteins terminated by mannose or N-acetylglucosamine

1980 • 81 citations

Antibody directed enzyme prodrug therapy (ADEPT): clinical report.

1991 • 79 citations

Endocytosis via galactose receptors in vivo

1986 • 78 citations

N‐(2‐hydroxypropyl) methacrylamide copolymers containing pendant saccharide moieties: Synthesis and bioadhesive properties

1991 • 63 citations

Advances in biomedical polymers

1987 • 60 citations

Antibody directed enzyme prodrug therapy (ADEPT): a three phase system.

1991 • 58 citations

In vivo quantification of receptor-mediated uptake of asialoglycoproteins by rat liver.

1983 • 46 citations

Synthetic Polymers Conjugated to Monoclonal Antibodies: Vehicles for Tumour-Targeted Drug Delivery

1991 • 44 citations

Decreased hepatic function in patients with hepatoma or liver metastasis monitored by a hepatocyte specific galactosylated radioligand

1990 • 44 citations

Immunological problems of polymer-bound drugs.

1985 • 43 citations

Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers

1986 • 42 citations

Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug carriers

1986 • 41 citations

The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour

1991 • 39 citations

In vitro bioadhesion of carbohydrate-containing N-(2-hydroxypropyl) methacrylamide copolymers to the GI tract of guinea pigs

1992 • 38 citations

Immunogenicity of Protein-N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates in A/J and B10 Mice

1990 • 38 citations

POLYVINYLPYRROLIDONE‐STORAGE DISEASE.

1976 • 36 citations

Potential of Sugar Residues Attached to N-(2- Hydroxypropyl)methacryl amide Copolymers as Targeting Groups for the Selective Delivery of Drugs

1987 • 35 citations

Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat

1991 • 35 citations

Biodistribution of ricin toxin A chain-monoclonal antibody 791T/36 immunotoxin and influence of hepatic blocking agents.

1987 • 30 citations

Fate of glycosylated dextrans after in vivo administration

1991 • 30 citations

Polymer‐bound derivatives of sarcolysin and their antitumour activity against mouse and human leukaemia in vitro

1987 • 27 citations

Targeting of daunorubicin by association with DNA or proteins: a review.

1984 • 25 citations

Intraperitoneal and subcutaneous retention of a soluble polymeric drug-carrier bearing galactose

1991 • 22 citations

Targeted protection of hepatocytes from galactosamine toxicity in vivo

1990 • 19 citations

Immunotoxins: the power and the glory

1992 • 13 citations

Hepatic uptake of asialoglycoprotein is different among mammalian species due to different receptor distribution

1988 • 12 citations

Chemoembolism in cancer chemotherapy.

1991 • 9 citations

The specificity of recognition by isolated rat peritoneal macrophages of N-(2-hydroxypropyl)methacrylamide copolymers containing mannosamine

1988 • 8 citations

Pilotage des anthracyclines et hépatomes.

1987 • 8 citations

Lymph-node Changes Due to Polyvinyl Pyrrolidone

1957 • 6 citations

Persistent perineal sinus following an abdominoperineal amputation: An unusual form of polyvinylpyrrolidone storage disease

1988 • 3 citations

Endocytosis of proteins by liver cells

1979 • 2 citations

Polymer-bound enzyme inhibitors: synthesis, properties, and physiological relevance.

1992 • 1 citations

Synthesis and in vivo evaluation of glycosylated dextrans for site-specific drug delivery

1992 • 1 citations

Deleted Work

1955 • 0 citations