Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

2001 • 2,560 citations

Neuroblastoma: biological insights into a clinical enigma

2003 • 2,087 citations

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

2001 • 1,824 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

The RB and p53 pathways in cancer

2002 • 1,612 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Diversity of gene expression in adenocarcinoma of the lung

2001 • 1,299 citations

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

2003 • 1,066 citations

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

2001 • 1,020 citations

Induction of medulloblastomas inp53-null mutant mice by somatic inactivation ofRbin the external granular layer cells of the cerebellum

2000 • 817 citations

The retinoblastoma tumour suppressor in development and cancer

2002 • 736 citations

Targeted disruption of the three Rb-related genes leads to loss of G₁ control and immortalization

2000 • 583 citations

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

2000 • 504 citations

Focus on lung cancer

2002 • 491 citations

The Developmental Biology of Brain Tumors

2001 • 462 citations

An achaete-scute homologue essential for neuroendocrine differentiation in the lung

1997 • 439 citations

Neuroepithelial Bodies of Pulmonary Airways Serve as a Reservoir of Progenitor Cells Capable of Epithelial Regeneration

2000 • 438 citations

Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

2000 • 415 citations

The retinoblastoma gene family in differentiation and development

1999 • 409 citations

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium

2000 • 408 citations

Molecular genetics of small cell lung carcinoma

2001 • 378 citations

Cooperative tumorigenic effects of germline mutations in Rb and p53

1994 • 374 citations

Value of Thyroid Transcription Factor-1 Immunostaining in Distinguishing Small Cell Lung Carcinomas From Other Small Cell Carcinomas

2000 • 331 citations

Molecular Genetics of Lung Cancer

2003 • 316 citations

N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling

2001 • 305 citations

The p53-deficient mouse: a model for basic and applied cancer studies

1996 • 256 citations

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

1994 • 253 citations

Lung cancer in Europe in 2000: epidemiology, prevention, and early detection

2003 • 244 citations

Conditional Clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells

2000 • 233 citations

Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene

2001 • 203 citations

Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors.

1993 • 180 citations

Molecular and Genetic Aspects of Lung Cancer

2000 • 163 citations

Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC)

2001 • 143 citations

p63 and TTF-1 Immunostaining: A Useful Marker Panel for Distinguishing Small Cell Carcinoma of Lung From Poorly Differentiated Squamous Cell Carcinoma of Lung

2003 • 142 citations

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse

1998 • 138 citations

Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice.

2000 • 123 citations

Chemotherapy for small cell lung cancer

2003 • 119 citations

Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages.

1996 • 112 citations

Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation

2002 • 95 citations

Evidence That Helix-Loop-Helix Proteins Collaborate with Retinoblastoma Tumor Suppressor Protein to Regulate Cortical Neurogenesis

2000 • 94 citations

Mechanism of Retinoblastoma Gene Inactivation in the Spectrum of Neuroendocrine Lung Tumors

1998 • 81 citations

p63 and TTF-1 Immunostaining: A Useful Marker Panel for Distinguishing Small Cell Carcinoma of Lung From Poorly Differentiated Squamous Cell Carcinoma of Lung

2003 • 81 citations

Molecular and cellular biology of small cell lung cancer

2003 • 71 citations

Pathology of small-cell lung cancer

2000 • 69 citations

The biological characteristics of chromogranin A and its role as a circulating marker in neuroendocrine tumours.

2000 • 58 citations

Cyclin-dependent kinase inhibitor expression in pulmonary Clara cells transformed with SV40 large T antigen in transgenic mice.

1997 • 45 citations

Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms

1999 • 34 citations

The Significance of NSE and CEA as a Differentiation Marker for the Cellular Heterogeneity of Small Cell Lung Cancer

1999 • 8 citations