Modulation of 11β-Hydroxysteroid Dehydrogenase Isozymes by Growth Hormone and Insulin-Like Growth Factor: In Vivo and In Vitro Studies1

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

1988 • 1,047 citations

11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1997 • 851 citations

MINERALOCORTICOID ACTIVITY OF LIQUORICE: 11-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY COMES OF AGE

1987 • 784 citations

Does central obesity reflect “Cushing's disease of the omentum”?

1997 • 755 citations

Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme

1994 • 707 citations

Clinical Aspects of Growth Hormone Deficiency in Adults

1995 • 690 citations

Growth Hormone and the Heart

1994 • 526 citations

11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess*

1997 • 515 citations

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

1991 • 434 citations

Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.

1988 • 420 citations

Clinical aspects of growth hormone deficiency in adults

1995 • 385 citations

11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations.

1995 • 301 citations

Urinary free cortisone and the assessment of 11β‐hydroxysteroid dehydrogenase activity in man

1996 • 269 citations

Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation.

1995 • 268 citations

Differentiation of Adipose Stromal Cells: The Roles of Glucocorticoids and 11β-Hydroxysteroid Dehydrogenase*

1999 • 251 citations

Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research

1993 • 247 citations

Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene

1996 • 235 citations

Immunohistochemical Localization of Type 1 11β-Hydroxysteroid Dehydrogenase in Human Tissues1

1998 • 198 citations

Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform.

1994 • 176 citations

Depot long-acting somatostatin analog (Sandostatin-LAR) is an effective treatment for acromegaly.

1995 • 151 citations

The effect of growth hormone replacement therapy on cortisol-cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11beta-hydroxysteroid dehydrogenase activity

1998 • 125 citations

BODY COMPOSITION IN ACROMEGALY

1989 • 124 citations

The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults

1994 • 121 citations

Sexual dimorphism of hepatic 11β-hydroxysteroid dehydrogenase in the rat: the role of growth hormone patterns

1994 • 112 citations

Human 11β-hydroxysteroid dehydrogenase: Studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue

1997 • 100 citations

Localization of the growth hormone receptor, identified by immunocytochemistry, in second trimester human fetal tissues and in placenta throughout gestation.

1992 • 98 citations

11β‐Hydroxysteroid dehydrogenase: implications for clinical medicine

1996 • 83 citations

Apparent cortisone reductase deficiency: a unique form of hypercortisolism.

1996 • 83 citations

Sexual dimorphism in 11 β hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects

1998 • 68 citations

A monoclonal antibody to human insulin-like growth factor-I: characterization, use in radioimmunoassay and effect on the biological activities of the growth factor

1989 • 63 citations

The effect of growth hormone replacement therapy on cortisol-cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11beta-hydroxysteroid dehydrogenase activity

1998 • 51 citations

Effect of growth hormone, insulin and dexamethasone on 11 β -hydroxysteroid dehydrogenase activity on a primary culture of rat hepatocytes

1996 • 48 citations

Clinical and biochemical response following withdrawal of a long‐acting, depot injection form of octreotide (Sandostatin‐LAR^®)

1999 • 44 citations

Apparent cortisone reductase deficiency: a unique form of hypercortisolism

1996 • 38 citations

Growth hormone replacement inhibits renal and hepatic 11β–hydroxysteroid dehydrogenases in ACTH‐deficient patients

1998 • 35 citations

Localization and characterization of IGF-I receptors in fetal and adult human kidneys.

1992 • 11 citations