The relationship between traumatic brain injury-induced changes in brain temperature and behavioral and anatomical outcome

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

1987 • 1,821 citations

Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain.

1989 • 1,110 citations

Animal Physiology: Adaptation and environment

1985 • 1,049 citations

Amphetamine, Haloperidol, and Experience Interact to Affect Rate of Recovery After Motor Cortex Injury

1982 • 916 citations

Responses to cortical injury: I. Methodology and local effects of contusions in the rat

1981 • 691 citations

Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state

1991 • 571 citations

Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury

1991 • 529 citations

Changes in Cortical Extracellular Levels of Energy-Related Metabolites and Amino Acids following Concussive Brain Injury in Rats

1990 • 521 citations

Thermal biology of the laboratory rat

1990 • 518 citations

Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury

1989 • 461 citations

The Importance of Brain Temperature in Alterations of the Blood-Brain Barrier Following Cerebral Ischemia

1990 • 373 citations

Mild Cerebral Hypothermia during and after Cardiac Arrest Improves Neurologic Outcome in Dogs

1990 • 363 citations

The Significance of Brain Temperature in Focal Cerebral Ischemia: Histopathological Consequences of Middle Cerebral Artery Occlusion in the Rat

1992 • 353 citations

The Influence of Mild Body and Brain Hypothermia on Ischemic Brain Damage

1990 • 351 citations

Effects of normothermic versus mild hyperthermic forebrain ischemia in rats.

1990 • 327 citations

Intraoperative warming therapies: a comparison of three devices

1992 • 318 citations

The importance of brain temperature in cerebral ischemic injury.

1989 • 318 citations

A comparative study of the role of the cerebral arterial blood in the regulation of brain temperature in five mammals

1969 • 272 citations

The importance of avoiding ?dark? neurons in experimental neuropathology

1961 • 259 citations

Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain

1980 • 252 citations

The Metabolic Effects of Mild Hypothermia on Global Cerebral Ischemia and Recirculation in the Cat: Comparison to Normothermia and Hyperthermia

1989 • 240 citations

The metabolic response to severe head injury

1984 • 239 citations

Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in Rats as Measured with Radiolabeled Microspheres

1989 • 216 citations

Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats.

1992 • 210 citations

A Comparison of the Cerebrovascular and Metabolic Effects of Halothane and Isolflurane in the Cat

1984 • 208 citations

Mechanical brain injury: the sympathoadrenal response

1984 • 203 citations

Mild hypothermia and Mg++ protect against irreversible damage during CNS ischemia.

1984 • 196 citations

Prevention of Postischemic Hyperthermia Prevents Ischemic Injury of CA₁ Neurons in Gerbils

1990 • 186 citations

Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats

1992 • 180 citations

Protection from cerebral ischemia by brain cooling without reduced lactate accumulation in dogs.

1989 • 145 citations

Interrelationships between increased vascular permeability and acute neuronal damage following temperature-controlled brain ischemia in rats

1991 • 142 citations

Effects of fluid-percussion brain injury on regional cerebral blood flow and pial arteriolar diameter

1986 • 139 citations

Integration and Central Processing in Temperature Regulation

1986 • 137 citations

The acute-phase response of the brain-injured patient

1988 • 130 citations

Relationship between body and brain temperature in traumatically brain-injured rodents

1991 • 126 citations

Experimental head injury in the rat

1977 • 123 citations

Stress-induced rise of body temperature in rats is the same in warm and cool environments

1990 • 120 citations

Traumatic Brain Injury in the Rat: Alterations in Brain Lactate and pH as Characterized by ¹H and ³¹P Nuclear Magnetic Resonance

1987 • 120 citations

THE EFFECT OF VOLATILE ANAESTHETICS ON LEVELS OF METABOLITES AND ON METABOLIC RATE IN BRAIN¹

1971 • 119 citations

Effects of Traumatic Brain Injury on Cerebral High-Energy Phosphates and pH: A³¹P Magnetic Resonance Spectroscopy Study

1987 • 119 citations

Temperature regulation in laboratory mammals following acute toxic insult

1988 • 115 citations

Preservation of brain temperature during ischemia in rats.

1990 • 114 citations

Early changes of intracranial pressure, perfusion pressure, and blood flow after acute head injury

1989 • 107 citations

The Significance of Posttraumatic Increase in Cerebral Blood Flow Velocity

1992 • 97 citations

Hypothermia in the Treatment of Craniocerebral Traumatism

1958 • 91 citations

Temperature dependence of hypoxia-induced calcium accumulation in gerbil hippocampal slices

1991 • 90 citations

Selective chromatolysis of neurons in the gerbil brain: A possible consequence of “epileptic” activity produced by common carotid artery occlusion

1979 • 87 citations

The Role of Cerebral Metabolism in Determining the Local Cerebral Blood Flow Effects of Volatile Anesthetics: Evidence for Persistent Flow-Metabolism Coupling

1989 • 86 citations

Cerebral energy metabolism following fluid-percussion brain injury in cats

1988 • 86 citations

Effects of hypothermia on evoked potentials, magnetic resonance imaging, and blood flow in focal ischemia in rabbits.

1992 • 83 citations

Experimental head injury in the rat

1977 • 78 citations

Responses to cortical injury: II. Widespread depression of the activity of an enzyme in cortex remote from a focal injury

1981 • 73 citations

Oxidative metabolic activity of cerebral cortex after fluid-percussion head injury in the cat

1981 • 68 citations

Methodological Requirements for Accurate Measurements of Brain and Body Temperature during Global Forebrain Ischemia of Rat

1992 • 63 citations

Rate of cerebral energy consumption in concussive head injury in the rat

1977 • 59 citations

Protective Effect of Hypothermia in Cerebral Oxygen Deficiency Caused by Arterial Hypoxia

1976 • 57 citations

Hypothermia is critical for survival during prolonged insulin-induced hypoglycemia in rats

1991 • 55 citations

Heat Balance during Physical Restraint in Rats

1979 • 54 citations

Hippocampal cell death following ischemia: Effects of brain temperature and anesthesia

1990 • 54 citations

Protective Effects of Combinations of Hypothermia and Barbiturates in Cerebral Hypoxia in the Rat

1978 • 53 citations

Trauma‐induced golgi‐like staining of neurons: A new approach to neuronal organization and response to injury

1990 • 52 citations

Global cerebral ischemia and subsequent selective hypothermia

1991 • 51 citations

Hypothermic protection following middle cerebral artery occlusion in the rat

1991 • 47 citations

The Significance of Posttraumatic Increase in Cerebral Blood Flow Velocity

1992 • 46 citations

Positron emission tomographic studies on cerebral hemodynamics in patients with cerebral contusion

1990 • 42 citations

Preservation of hippocampal brain slices with in vivo or in vitro hypothermia

1992 • 41 citations

The cortical area concerned with coordinated walking in the rat

1935 • 41 citations

Positron Emission Tomographic Studies on Cerebral Hemodynamics in Patients with Cerebral Contusion

1990 • 38 citations

Modification of the Relationship between Cerebral Metabolism, Blood Flow, and Electroencephalogram by Stimulation during Anesthesia in the Dog

1979 • 36 citations

Brain temperature and brain blood flow in unanesthetized rats

1965 • 35 citations

The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex

1991 • 30 citations

Thermal resistance and sensible heat loss from animals

1981 • 29 citations

Core Temperature Changes during N2O Fentanyl and Halothane/O2 Anesthesia

1987 • 28 citations

The influence of hypothermia on hypoglycemia-induced brain damage in the rat

1992 • 25 citations

Degeneration of hippocampal CA1 neurons following transient ischemia due to raised intracranial pressure: evidence for a temperature-dependent excitotoxic process

1990 • 24 citations

The effect of concussion on cerebral uptake of 2-deoxy-d-glucose in rat

1983 • 23 citations

Isolated Stimulation of Glycolysis Following Traumatic Brain Injury

1989 • 21 citations

The effects of brain temperature on temporary global ischaemia in rat brain. A 31‐phosphorous NMR spectroscopy study

1992 • 21 citations

Habituation of plasma catecholamine responses to chronic intermittent restraint stress

1990 • 14 citations

A simple, inexpensive method of monitoring brain temperature in conscious rodents

1990 • 14 citations