Neuroprotective Effects of Estradiol in Middle-Aged Female Rats¹

Comparative distribution of estrogen receptor-? and -? mRNA in the rat central nervous system

1997 • 2,244 citations

Estrogen Actions in the Central Nervous System¹

1999 • 1,381 citations

Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood

1990 • 1,352 citations

The Control of Progesterone Secretion During the Estrous Cycle and Early Pseudopregnancy in the Rat: Prolactin, Gonadotropin and Steroid Levels Associated with Rescue of the Corpus Luteum of Pseudopregnancy¹²

1975 • 1,281 citations

Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat

1993 • 1,066 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

1997 • 769 citations

Gender-Linked Brain Injury in Experimental Stroke

1998 • 730 citations

17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro

1995 • 612 citations

The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons

1999 • 581 citations

Estradiol Protects against Ischemic Injury

1998 • 548 citations

Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat

1997 • 512 citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

1997 • 478 citations

Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways

1999 • 474 citations

Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors

1999 • 453 citations

Chronological Changes in Sex Steroid, Gonadotropin and Prolactin Secretion in Aging Female Rats Displaying Different Reproductive States1

1979 • 403 citations

Regulation of Dendritic Spine Density in Cultured Rat Hippocampal Neurons by Steroid Hormones

1996 • 402 citations

Estrogen-Mediated Neuroprotection After Experimental Stroke in Male Rats

1998 • 362 citations

Neuroprotective Effects of Female Gonadal Steroids in Reproductively Senescent Female Rats

2000 • 336 citations

Gender influences outcome of brain injury: progesterone plays a protective role

1993 • 320 citations

Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.

1996 • 283 citations

17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors

1997 • 278 citations

Estradiol upregulates Bcl-2 expression in adult brain neurons

1998 • 253 citations

Sex Differences in Postischemic Neuronal Necrosis in Gerbils

1991 • 253 citations

Estradiol Exerts Neuroprotective Effects When Administered After Ischemic Insult

2000 • 233 citations

Estrogens: Trophic and Protective Factors in the Adult Brain

2001 • 232 citations

Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury

1993 • 221 citations

Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rat

1996 • 219 citations

Effects of gender and estradiol treatment on focal brain ischemia

1998 • 215 citations

17 beta-Estradiol enhances the outgrowth and survival of neocortical neurons in culture.

1997 • 184 citations

Modulation of Bcl-2 expression

1998 • 173 citations

17?-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid ?-peptide and iron

1997 • 163 citations

Postischemic Cerebral Blood Flow Recovery in the Female: Effect of 17β-Estradiol

1995 • 151 citations

Cerebral vasodilating capacity during forebrain ischemia

1998 • 146 citations

Experimental Stroke and Neuroprotection in the Aging Rat Brain

1995 • 136 citations

Effect of Age in Rodent Models of Focal and Forebrain Ischemia

1996 • 135 citations

Estradiol-Induced Daily Luteinizing Hormone and Prolactin Surges in Young and Middle-Aged Rats: Correlations with Age-Related Changes in Pituitary Responsiveness and Catecholamine Turnover Rates in Microdissected Brain Areas*

1984 • 133 citations

Local Uncoupling of the Cerebrovascular and Metabolic Responses to Somatosensory Stimulation after Neuronal Nitric Oxide Synthase Inhibition

1997 • 131 citations

Aging Alters the Rhythmic Expression of Vasoactive Intestinal Polypeptide mRNA But Not Arginine Vasopressin mRNA in the Suprachiasmatic Nuclei of Female Rats

1998 • 120 citations

Decline in immediate early gene expression in gonadotropin-releasing hormone neurons during proestrus in regularly cycling, middle-aged rats.

1994 • 109 citations

Estrogen status affects sensitivity to focal cerebral ischemia in stroke-prone spontaneously hypertensive rats

2000 • 106 citations

Norepinephrine and Dopamine Activity in Microdissected Brain Areas of the Middle-Aged and Young Rat on Proestrus1

1982 • 98 citations

Organotypic culture of the developing cerebral cortex and hypothalamus: Relevance to sexual differentiation

1991 • 94 citations

Estradiol Protects Against Ischemic Brain Injury in Middle-Aged Rats1

2000 • 92 citations

The effects of 17β-estradiol on ischemia-induced neuronal damage in the gerbil hippocampus

1998 • 87 citations

Regional Cerebral Blood Flow during and after 2 Hours of Middle Cerebral Artery Occlusion in the Rat

1997 • 74 citations

Embolic stroke in aged rats.

1991 • 64 citations

Age-related vulnerability to cerebral ischemia in spontaneously hypertensive rats.

1991 • 62 citations

Effect of Age and Sex on N -Methyl- <scp>d</scp> -Aspartate Antagonist-Induced Neuronal Necrosis in Rats

1996 • 60 citations

Estrogen-dependent modulation of rat brain ascorbate levels and ischemia-induced ascorbate loss

1998 • 55 citations

Age-Related Changes in the Diurnal Rhythm of Serotonin Turnover in Microdissected Brain Areas of Estradiol-Treated Ovariectomized Rats*

1988 • 45 citations

A Reproducible Model of Middle Cerebral Infarcts, Compatible with Long-term Survival, in Aged Rats

1995 • 41 citations

Aging abolishes the estradiol-induced suppression and diurnal rhythm of proopiomelanocortin gene expression in the arcuate nucleus.

1992 • 40 citations

Age-related changes in cytoplasmic estradiol receptor concentrations in microdissected brain nuclei: Correlations with changes in steroid-induced sexual behavior

1984 • 39 citations

Age-associated increases in serum follicle-stimulating hormone levels on estrus are accompanied by a reduction in the ovarian secretion of inhibin

1987 • 33 citations

Transient global brain ischemia in young and aged rats: differences in severity and progression, but not localisation, of lesions evaluated by magnetic resonance imaging

1998 • 21 citations

Neurologic Outcome in Aged Rats After Incomplete Cerebral Ischemia

1988 • 10 citations