Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

Photochemically generated cytosolic calcium pulses and their detection by fluo-3

1989 • 820 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

New roles for G-protein (βγ-dimers in transmembrane signalling

1993 • 633 citations

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

1990 • 615 citations

Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.

1990 • 567 citations

The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.

1991 • 453 citations

The signal for capacitative calcium entry

1993 • 423 citations

U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.

1992 • 302 citations

A GTP-dependent step in the activation mechanism of capacitative calcium influx.

1993 • 283 citations

Inositol phosphates and Ca ²⁺ entry: toward a proliferation or a simplification?

1992 • 184 citations

Inhibition of thapsigargin-induced calcium entry by microinjected guanine nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entry.

1993 • 183 citations

U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells.

1992 • 128 citations

Dopamine fails to inhibit renal tubular sodium pump in hypertensive rats.

1993 • 112 citations

Specificity of receptor-G protein interactions: Searching for the structure behind the signal

1993 • 106 citations

Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes

1992 • 89 citations

Actions of vasopressin and the Ca(2+)-ATPase inhibitor, thapsigargin, on Ca2+ signaling in hepatocytes.

1992 • 87 citations

Potentiation of inositol trisphosphate‐induced Ca2+ mobilization in Xenopus oocytes by cytosolic Ca2+.

1992 • 81 citations

Distinct muscarinic receptors, G proteins and phospholipases in esophageal and lower esophageal sphincter circular muscle.

1993 • 76 citations

Transient inhibition by chemotactic peptide of a store-operated Ca2+ entry pathway in human neutrophils

1993 • 74 citations

Mechanisms of receptor-mediated Ca2+ signaling in rat hepatocytes.

1991 • 64 citations

Role of Phosphoinositide Hydrolysis in Astrocyte Volume Regulation

1993 • 62 citations

U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets.

1993 • 49 citations

A slowly ADP-ribosylated pertussis-toxin-sensitive GTP-binding regulatory protein is required for vasopressin-stimulated Ca2+ inflow in hepatocytes

1994 • 34 citations

Differential Involvement of Phospholipase A2/Arachidonic Acid and Phospholipase C/Phosphoinositol Pathways during Cholecystokinin Receptor-Activated Ca2+ Oscillations in Pancreatic Acini

1993 • 34 citations

Decreased levels of internalized thyrotropin-releasing hormone receptors after uncoupling from guanine nucleotide-binding protein and phospholipase-C.

1993 • 32 citations

Inhibition of phospholipase D by agents that inhibit cell growth.

1993 • 30 citations

Evidence from studies with hepatocyte suspensions that store-operated Ca2+ inflow requires a pertussis toxin-sensitive trimeric G-protein

1994 • 28 citations

Effect of heat shock, [Ca2+]i, and cAMP on inositol trisphosphate in human epidermoid A-431 cells

1993 • 24 citations

A role for a pertussis toxin‐sensitive trimeric G‐protein in store‐operated Ca²⁺ inflow in hepatocytes

1994 • 23 citations

U-73122 does not specifically inhibit phospholipase C in rat pancreatic islets and insulin-secreting β-cell lines

1994 • 18 citations

Effect of Phospholipase C Inhibitor U-73122 on Antigen-induced Airway Smooth Muscle Contraction in Guinea Pigs

1993 • 15 citations

Contribution of G Protein Activation to Fluoride Stimulation of Phosphoinositide Hydrolysis in Human Neuroblastoma Cells

1993 • 13 citations

Stimulation of the intracellular killing of Staphylococcus aureus by human monocytes mediated by Fcγ receptors I and II

1993 • 12 citations