Apoptosomes: engines for caspase activation

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

The Inflammasome

2002 • 5,445 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Mechanisms of Caspase Activation and Inhibition during Apoptosis

2002 • 1,731 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Apoptosis Signaling

2000 • 1,290 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

Caspase activation: The induced-proximity model

1999 • 920 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

Three-Dimensional Structure of the Apoptosome

2002 • 879 citations

Negative regulation of the Apaf-1 apoptosome by Hsp70

2000 • 819 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

1999 • 725 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

1998 • 628 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Caspase-9 and APAF-1 form an active holoenzyme

1999 • 566 citations

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

2002 • 564 citations

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

2000 • 558 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

The CARD domain: a new apoptotic signalling motif

1997 • 532 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

ASC, a Novel 22-kDa Protein, Aggregates during Apoptosis of Human Promyelocytic Leukemia HL-60 Cells

1999 • 516 citations

The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

2001 • 514 citations

Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation

1999 • 502 citations

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

2000 • 501 citations

Caspase-9 Can Be Activated without Proteolytic Processing

1999 • 498 citations

Cytochrome c Promotes Caspase-9 Activation by Inducing Nucleotide Binding to Apaf-1

2000 • 493 citations

Genetic Control of Programmed Cell Death in the Nematode Caenorhabditis Elegans

1994 • 488 citations

Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1

2001 • 439 citations

Dimer formation drives the activation of the cell death protease caspase 9

2001 • 425 citations

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

1999 • 415 citations

Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway

1999 • 329 citations

The Drosophila caspase DRONC is regulated by DIAP1

2000 • 322 citations

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

2000 • 321 citations

Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis

1998 • 269 citations

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

1998 • 252 citations

Nods: a family of cytosolic proteins that regulate the host response to pathogens

2002 • 250 citations

Control of the Cell Death Pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-Related Caspase Activator

1999 • 242 citations

Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death

2000 • 236 citations

The Drosophila caspase DRONC is a glutamate/aspartate protease whose activity is regulated by DIAP1, HID and GRIM

2000 • 226 citations

HAC-1, a Drosophila Homolog of APAF-1 and CED-4, Functions in Developmental and Radiation-Induced Apoptosis

1999 • 203 citations

Adult Apaf-1-Deficient Mice Exhibit Male Infertility

2000 • 202 citations

The Drosophila Caspase DRONC Cleaves following Glutamate or Aspartate and Is Regulated by DIAP1, HID, and GRIM

2000 • 190 citations

The role of cytochrome c in caspase activation in Drosophila melanogaster cells

2002 • 188 citations

A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis

2001 • 183 citations

The role of ARK in stress-induced apoptosis in Drosophila cells

2002 • 162 citations

An Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death in Drosophila

2000 • 160 citations

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1999 • 157 citations

Molecular Cloning and Characterization of DEFCAP-L and -S, Two Isoforms of a Novel Member of the Mammalian Ced-4 Family of Apoptosis Proteins

2001 • 149 citations

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL

2000 • 142 citations

Altered Cytochrome c Display Precedes Apoptotic Cell Death in Drosophila

1999 • 123 citations

Human CARD12 Is a Novel CED4/Apaf-1 Family Member That Induces Apoptosis

2001 • 115 citations

CLAN, a Novel Human CED-4-like Gene

2001 • 72 citations

Disruption of the CED-9/CED-4 Complex by EGL-1 is a Critical Step for Programmed Cell Death in C. elegans

2000 • 62 citations

Disruption of the CED-9·CED-4 Complex by EGL-1 Is a Critical Step for Programmed Cell Death inCaenorhabditis elegans

2000 • 54 citations

Demonstration of thein vivointeraction of key cell death regulators by structure-based design of second-site suppressors

2000 • 48 citations

Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1

2001 • 21 citations