Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

1995 • 1,158 citations

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene

1992 • 1,025 citations

Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection

1995 • 1,008 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

1992 • 496 citations

Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain

1996 • 433 citations

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1994 • 401 citations

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene

1994 • 372 citations

The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus

1990 • 335 citations

Vaccine protection by a triple deletion mutant of simian immunodeficiency virus

1996 • 325 citations

Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication.

1987 • 310 citations

HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

1994 • 305 citations

Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

1992 • 299 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.

1989 • 266 citations

Techniques in HIV Research

1990 • 263 citations

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.

1995 • 256 citations

Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

1995 • 252 citations

Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.

1989 • 227 citations

Human immunodeficiency virus type 1 Nef associateswith a cellular serine kinase in T lymphocytes.

1994 • 227 citations

High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection

1996 • 222 citations

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1997 • 206 citations

Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection

1995 • 191 citations

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef

1995 • 191 citations

CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals.

1993 • 186 citations

Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family

1996 • 154 citations

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

1996 • 142 citations

CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1

1996 • 137 citations

Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells

1992 • 123 citations

Human retroviruses and aids, 1992

1992 • 119 citations

Characterization of a CD4-Expressing Macaque Cell Line That Can Detect Virus after a Single Replication Cycle and Can Be Infected by Diverse Simian Immunodeficiency Virus Isolates

1995 • 105 citations

Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene

1994 • 80 citations

Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression

1995 • 65 citations

Experimental infection of macaques with HIV-2ben, a novel HIV-2 isolate

1990 • 63 citations

The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent

1996 • 56 citations

Transient assay for Nef-induced down-regulation of CD4 antigen expression on the cell surface

1995 • 8 citations