Functional and structural characteristics of EGF and its receptor and their relationship to transforming proteins

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

1979 • 1,758 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

1982 • 788 citations

Recycling receptors: The round-trip itinerary of migrant membrane proteins

1983 • 780 citations

Isolation and structure of urogastrone and its relationship to epidermal growth factor

1975 • 751 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor

1982 • 675 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

1984 • 666 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431.

1978 • 578 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

The Primary Structure of Epidermal Growth Factor

1972 • 533 citations

Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.

1979 • 530 citations

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

1979 • 528 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

Biochemistry and physiology of the skin

1983 • 487 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro

1978 • 448 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.

1983 • 414 citations

Purification and initial characterization of a type beta transforming growth factor from human placenta.

1983 • 409 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Epidermal Growth Factor: Effects of Androgens and Adrenergic Agents

1974 • 393 citations

Biochemistry and physiology of the skin

1991 • 388 citations

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

1984 • 377 citations

Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells

1976 • 374 citations

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

1978 • 372 citations

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.

1983 • 369 citations

Isolation of a calcium-dependent 35-kilodalton substrate for the epidermal growth factor receptor/kinase from A-431 cells.

1984 • 366 citations

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

1982 • 366 citations

The effect of serum, EGF, PGF2α and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis

1982 • 362 citations

Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.

1984 • 357 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

Role of epidermal growth factor in carcinogenesis.

1986 • 330 citations

Serum contains a platelet-derived transforming growth factor.

1982 • 330 citations

Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages

1984 • 316 citations

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

1985 • 310 citations

Transformation by Rous sarcoma virus: effects of src gene expression on the synthesis and phosphorylation of cellular polypeptides.

1979 • 293 citations

Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in Psoriasis

1986 • 289 citations

Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor

1984 • 267 citations

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

1984 • 266 citations

Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells.

1982 • 263 citations

Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factor

1979 • 254 citations

Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor

1985 • 249 citations

Synthetic tyrosine polymers as substrates and inhibitors of tyrosine-specific protein kinases.

1984 • 246 citations

Human transforming growth factors induce tyrosine phosphorylation of EGF receptors

1981 • 244 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Epidermal Growth Factor

1973 • 233 citations

Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells.

1982 • 232 citations

alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions.

1979 • 232 citations

Glycosylation of the epidermal growth factor receptor in A-431 cells. The contribution of carbohydrate to receptor function.

1984 • 229 citations

Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

1984 • 219 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Epidermal Growth Factor: High and Low Molecular Weight Forms

1970 • 206 citations

Inhibition of epidermal growth factor binding to surface receptors by tumor promotors

1979 • 206 citations

Production of an Epidermal Growth Factor Receptor-Related Protein

1984 • 202 citations

Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors.

1984 • 201 citations

Immunohistochemical localisation of urogastrone to human duodenal and submandibular glands.

1978 • 198 citations

Growth factors: The epidermal growth factor receptor gene and its product

1984 • 187 citations

In vitro phosphorylation of angiotensin analogs by tyrosyl protein kinases.

1983 • 186 citations

Immunoaffinity purification of the epidermal growth factor receptor. Stoichiometry of binding and kinetics of self-phosphorylation.

1984 • 186 citations

Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver.

1982 • 183 citations

Epidermal Growth Factor (Urogastrone) in Human Fluids: Size Heterogeneity*

1979 • 183 citations

Radioimmunoassay of Human Epidermal Growth Factor (Urogastrone)1

1977 • 182 citations

Cellular localisation of human urogastrone/epidermal growth factor

1978 • 179 citations

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts.

1982 • 171 citations

Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.

1983 • 168 citations

Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro

1985 • 160 citations

Diverse Mitogenic Agents Induce the Phosphorylation of Two Related 42,000-Dalton Proteins on Tyrosine in Quiescent Chick Cells

1984 • 159 citations

Effect of L-alpha-phosphatidylinositol on a vascular smooth muscle Ca2+-dependent protease. Reduction of the Ca2+ requirement for autolysis.

1984 • 156 citations

Biosynthesis of the epidermal growth factor receptor in A431 cells.

1984 • 156 citations

beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.

1983 • 156 citations

Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor

1979 • 154 citations

Characterization by electrophoresis of epidermal growth factor stimulated phosphorylation using A-431 membranes

1980 • 153 citations

Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor.

1983 • 148 citations

Evidence That the v- sis Gene Product Transforms by Interaction with the Receptor for Platelet-Derived Growth Factor

1985 • 138 citations

Evidence that viral transforming gene products and epidermal growth factor stimulate phosphorylation of the same cellular protein with similar specificity.

1981 • 137 citations

A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta.

1984 • 137 citations

Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region.

1984 • 133 citations

Hepatic sequestration and biliary secretion of epidermal growth factor: evidence for a high-capacity uptake system.

1983 • 131 citations

The biosynthetic precursor of epidermal growth factor and the mechanism of its processing.

1979 • 131 citations

Purified EGF receptor–kinase interacts specifically with antibodies to Rous sarcoma virus transforming protein

1981 • 130 citations

EPIDERMAL GROWTH FACTOR STIMULATES SECRETION OF HUMAN CHORIONIC GONADOTROPIN BY CULTURED HUMAN CHORIOCARCINOMA CELLS

1978 • 126 citations

The kinetics of tyrosine phosphorylation by the purified epidermal growth factor receptor kinase of A-431 cells.

1983 • 124 citations

Modelling the ATP‐binding site of oncogene products, the epidermal growth factor receptor and related proteins

1984 • 121 citations

Post-translational processing of the epidermal growth factor receptor. Glycosylation-dependent acquisition of ligand-binding capacity.

1985 • 119 citations

Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblasts.

1983 • 118 citations

The Human Gene for the β Subunit of Nerve Growth Factor Is Located on the Proximal Short Arm of Chromosome 1

1983 • 113 citations

Concentrations of Epidermal Growth Factor, Nerve Growth Factor, and Submandibular Gland Renin in Male and Female Mouse Tissue and Fluids*

1979 • 110 citations

Transformation Induced by Abelson Murine Leukemia Virus Involves Production of a Polypeptide Growth Factor

1982 • 108 citations

Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus.

1981 • 108 citations

Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.

1985 • 101 citations

Visualization of Epidermal Growth Factor Receptors in Human Epidermis

1984 • 100 citations

Epidermal Growth Factor Inhibits Cysteamine-Induced Duodenal Ulcers

1983 • 100 citations

Conformation and unfolding thermodynamics of epidermal growth factor and derivatives

1976 • 98 citations

The identification of urogastrone in serum, saliva, and gastric juice

1979 • 98 citations

Alteration of epidermal growth factor-dependent phosphorylation during rat liver regeneration.

1982 • 96 citations

Similarity between the vaccinia virus 19K early protein and epidermal growth factor

1985 • 95 citations

Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase.

1985 • 94 citations

Effects of Epidermal Growth Factor and 12-O-Tetradecanoylphorbol-13-Acetate on Metabolism of the Epidermal Growth Factor Receptor in Normal Human Fibroblasts

1984 • 94 citations

Characterization of the metabolic turnover of epidermal growth factor receptor protein in A‐431 cells

1984 • 94 citations

Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells.

1984 • 90 citations

Inhibition of epidermal growth factor binding to mouse cultured cells by fibroblast-derived growth factor. Evidence for an indirect mechanism.

1982 • 90 citations

A synthetic fragment of rat transforming growth factor α with receptor binding and antigenic properties

1985 • 86 citations

42,000-molecular weight EGF receptor has protein kinase activity

1984 • 85 citations

Characterization of the interaction of 5'-p-fluorosulfonylbenzoyl adenosine with the epidermal growth factor receptor/protein kinase in A431 cell membranes.

1983 • 83 citations

Characteristics of antibodies to the epidermal growth factor receptor-kinase

1983 • 79 citations

Virus- and cell-encoded tyrosine protein kinases inactivate DNA topoisomerases in vitro

1984 • 78 citations

Anti-pp60src antibodies are substrates for EGF-stimulated protein kinase

1981 • 78 citations

Blood group-active carbohydrate chains on the receptor for epidermal growth factor of A431 cells.

1984 • 78 citations

Two forms of murine epidermal growth factor: rapid separation by using reverse-phase HPLC.

1982 • 78 citations

Epidermal Growth Factor

1981 • 77 citations

Properties of a monoclonal antibody to epidermal growth factor receptor with implications for the mechanism of action of EGF.

1984 • 77 citations

Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase

1983 • 75 citations

Characterization of the High Molecular Weight Form of Epidermal Growth Factor

1974 • 72 citations

Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.

1985 • 72 citations

Characteristics of Insulin and Epidermal Growth Factor Stimulation of Receptor Autophosphorylation in Detergent Extracts of Rat Liver and Transplantable Rat Hepatomas*

1984 • 72 citations

Insulin and growth factors stimulate the phosphorylation of a Mr-22000 protein in 3T3-L1 adipocytes

1983 • 67 citations

Epidermal growth factor-induced topoisomerase(s)

1983 • 64 citations

Aspects of the Metabolism of the Epidermal Growth Factor Receptor in A431 Human Epidermoid Carcinoma Cells

1984 • 62 citations

Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor.

1982 • 60 citations

Synergistic stimulation of S6 ribosomal protein phosphorylation and DNA synthesis by epidermal growth factor and insulin in quiescent 3T3 cells

1982 • 60 citations

Identity of human epidermal growth factor (EGF) receptor with glycoprotein SA-7: evidence for differential phosphorylation of the two components of the EGF receptor from A431 cells.

1982 • 60 citations

ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA

1984 • 58 citations

Biology of the A‐431 cell: A useful organism for hormone research

1983 • 54 citations

Epidermal growth factor stimulates tyrosine phosphorylation of the myosin regulatory light chain from smooth muscle.

1983 • 53 citations

Controlled proteolysis of EGF receptors: Evidence for transmembrane distribution of the EGF binding and phosphate acceptor sites

1980 • 51 citations

Roles of growth factor activities in oncogenesis

1984 • 50 citations

Phosphorylation of the erbB gene product from an avian erythroblastosis virus-transformed chick fibroblast cell line.

1985 • 50 citations

cAMP-dependent protein kinase stimulates epidermal growth factor-dependent phosphorylation of epidermal growth factor receptors.

1984 • 50 citations

Solubilization of membrane receptor for epidermal growth factor

1979 • 49 citations

Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.

1984 • 49 citations

Calcium facilitates endogenous proteolysis of the EGF receptor-kinase

1982 • 48 citations

The effects of epidermal and fibroblast growth factors on the repair of corneal endothelial wounds in bovine corneas maintained in organ culture

1979 • 46 citations

Immunohistochemical localization of nerve growth factor and epidermal growth factor in guinea pig prostate gland

1984 • 45 citations

Modification of the epidermal growth factor affecting the stability of its high molecular weight complex.

1976 • 45 citations

Inhibition of the binding of 125I-labelled epidermal growth factor to mouse cells by a mitogen in goat mammary secretions

1983 • 45 citations

Characterization of structural domains of the human epidermal growth factor receptor obtained by partial proteolysis.

1984 • 44 citations

EPIDERMAL GROWTH FACTOR STIMULATES PRODUCTION OF PROGESTERONE IN CULTURED HUMAN CHORIOCARCINOMA CELLS

1980 • 44 citations

Roles of growth factor activities in oncogenesis

1984 • 44 citations

Epidermal Growth Factor in Mouse Milk during Early Lactation: Lack of Dependency on Submandibular Glands

1985 • 42 citations

Benzo[a]pyrene and other inducers of cytochrome P₁-450 inhibit binding of epidermal growth factor to cell surface receptors

1982 • 42 citations

Activation of calcium and phospholipid-dependent protein kinase by epidermal growth factor (EGF) in A431 cells: Attenuation by 12-0-tetradecanoylphorbol-13-acetate (TPA)

1982 • 40 citations

Synthetic peptide substrates for the membrane tyrosine protein kinase stimulated by epidermal growth factor

1984 • 39 citations

Similar transforming growth factors (TGFs) produced by cells transformed by different isolates of feline sarcoma virus

1983 • 39 citations

Lectin-agarose immobilization, a new method for detecting soluble membrane receptors. Application to studies with epidermal growth factor-urogastrone and transcobalamin-II.

1979 • 38 citations

Protein phosphorylation in human placenta stimulation by epidermal growth factor

1980 • 38 citations

Biosynthesis of the Epidermal Growth Factor Receptor in Cultured Human Cells*

1985 • 36 citations

Epidermal growth factor and epidermal growth factor receptor-dependent phosphorylation of a Mr = 34,000 protein substrate for pp60src.

1983 • 36 citations

Human epidermal growth factor/urogastrone: Rapid purification procedure and partial characterization

1981 • 36 citations

Selective reduction in receptors for epidermal growth factor-urogastrone in chemically transformed tumorigenic Syrian hamster embryo fibroblasts.

1979 • 36 citations

Aspects of the metabolism of the epidermal growth factor receptor in A431 human epidermoid carcinoma cells.

1984 • 33 citations

Is epidermal growth factor present in human blood? Interference with the radioreceptor assay for epidermal growth factor

1983 • 32 citations

Phosphorylation of the hepatic EGF receptor with cAMP-dependent protein kinase

1984 • 32 citations

Phosphorylation of human growth hormone by the epidermal growth factor-stimulated tyrosine kinase.

1983 • 31 citations

Enhancement of polyoma virus middle T antigen tyrosine phosphorylation by epidermal growth factor

1983 • 28 citations

Beta-epidermal growth factor is the des-asparaginyl form of the polypeptide.

1985 • 28 citations

Molecular species of epidermal growth factor carrying immunosuppressive activity

1984 • 25 citations

Secretion of Epidermal Growth Factor, Nerve Growth Factor, and Renin-Like Enzymes by Dispersed Male Mouse Submandibular Gland Cells in Vitro*

1980 • 25 citations

Epidermal growth factor precursor is related to the translation product of the Moloney sarcoma virus oncogene mos.

1985 • 24 citations

Saccharin and cyclamate inhibit binding of epidermal growth factor.

1981 • 20 citations

EGF receptor-associated DNA-nicking activity is due to a Mr-100,000 dissociable protein

1985 • 19 citations

A synthetic peptide containing the autophosphorylation site of the transforming protein of Harvey sarcoma virus is phosphorylated by the EGF‐stimulated tyrosine kinase

1983 • 18 citations

Transport of 125I-EGF into milk and effect of sialoadenectomy on milk EGF in mice

1984 • 16 citations

Direct modulation of epidermal growth factor binding by cholecystokinin

1983 • 14 citations

Phenotypic expression in Donohue syndrome (leprechaunism): A role for epidermal growth factor

1985 • 13 citations

Calmodulin antagonists decrease the binding of epidermal growth factor to transformed, but not to normal, human fibroblasts

1984 • 12 citations

Macroscale high-performance liquid chromatographic separation and instrumental identification of components of diethylaminoethyl murine epidermal growth factor

1984 • 10 citations

Modulation of protein phosphorylation in human colon adenocarcinoma cell membrane preparations by epidermal growth factor in vitro

1982 • 9 citations

Surface Iodination of Epidermal Growth Factor Receptors in Intact Cells

1984 • 7 citations

Photoaffinity labelling of the ATP-binding site of the epidermal growth factor-dependent protein kinase

1984 • 6 citations

An effect of fibronectin in epidermal growth factor (EGF)-stimulated membrane protein phosphorylation in human carcinoma cells

1982 • 3 citations

Inhibition of epidermal growth factor binding by prostaglandin A's

1981 • 2 citations