Prefrontal Cortex Stimulation Induces 2-Arachidonoyl-Glycerol-Mediated Suppression of Excitation in Dopamine Neurons

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1990 • 4,933 citations

Predictive Reward Signal of Dopamine Neurons

1998 • 4,446 citations

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

1995 • 2,837 citations

Getting Formal with Dopamine and Reward

2002 • 2,558 citations

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

1995 • 2,122 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

The endogenous cannabinoid system controls extinction of aversive memories

2002 • 1,689 citations

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

1994 • 1,564 citations

A second endogenous cannabinoid that modulates long-term potentiation

1997 • 1,474 citations

The control of firing pattern in nigral dopamine neurons: burst firing

1984 • 1,326 citations

Neurobiology of addiction

1996 • 1,082 citations

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1999 • 1,055 citations

Control of pain initiation by endogenous cannabinoids

1998 • 1,044 citations

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

2003 • 989 citations

The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis

2004 • 985 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition

1997 • 806 citations

Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro

1989 • 734 citations

Neurotransmitter regulation of dopamine neurons in the ventral tegmental area

1993 • 713 citations

Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action

1998 • 708 citations

Two types of neurone in the rat ventral tegmental area and their synaptic inputs.

1992 • 682 citations

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

1988 • 663 citations

Heterosynaptic LTD of Hippocampal GABAergic Synapses

2003 • 637 citations

Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens

2002 • 609 citations

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

1999 • 599 citations

Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids

2002 • 586 citations

Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid Receptors

2001 • 558 citations

Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat

1994 • 512 citations

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1978 • 498 citations

Burst firing in midbrain dopaminergic neurons

1997 • 482 citations

Pain modulation by release of the endogenous cannabinoid anandamide

1999 • 482 citations

Endocannabinoids Mediate Presynaptic Inhibition of Glutamatergic Transmission in Rat Ventral Tegmental Area Dopamine Neurons through Activation of CB1 Receptors

2004 • 466 citations

Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus

2001 • 421 citations

Metabotropic Glutamate Receptors Drive the Endocannabinoid System in Hippocampus

2001 • 406 citations

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB₁ Cannabinoid Receptor Knockout Mice

2000 • 399 citations

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 • 386 citations

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

1999 • 324 citations

Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor

1999 • 306 citations

Brain Regional Distribution of Endocannabinoids: Implications for Their Biosynthesis and Biological Function

1999 • 300 citations

Synaptic Regulation of Mesocorticolimbic Dopamine Neurons

1996 • 289 citations

Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons

1998 • 285 citations

Transient changes in mesolimbic dopamine and their association with ‘reward’

2002 • 282 citations

Burst firing induced in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices

1988 • 281 citations

Context‐dependent effects of CB1 cannabinoid gene disruption on anxiety‐like and social behaviour in mice

2004 • 274 citations

Structural determinants for recognition and translocation by the anandamide transporter

1999 • 270 citations

Endocannabinoid‐mediated short‐term synaptic plasticity: depolarization‐induced suppression of inhibition (DSI) and depolarization‐induced suppression of excitation (DSE)

2004 • 256 citations

Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids

2003 • 237 citations

Disruption of Endocannabinoid Release and Striatal Long-Term Depression by Postsynaptic Blockade of Endocannabinoid Membrane Transport

2004 • 232 citations

Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area

1985 • 231 citations

Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers

2002 • 207 citations

Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events

1996 • 187 citations

Transient increases in catecholaminergic activity in medial prefrontal cortex and nucleus accumbens shell during novelty

1996 • 184 citations

P2X₇receptors control 2-arachidonoylglycerol production by microglial cells

2004 • 181 citations

Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation

2002 • 181 citations

Two Intracellular Pathways Mediate Metabotropic Glutamate Receptor-Induced Ca²⁺Mobilization in Dopamine Neurons

2003 • 160 citations

Phosphatidic Acid as the Biosynthetic Precursor of the Endocannabinoid 2‐Arachidonoylglycerol in Intact Mouse Neuroblastoma Cells Stimulated with Ionomycin

1999 • 159 citations

The uptake by cells of 2‐arachidonoylglycerol, an endogenous agonist of cannabinoid receptors

2001 • 155 citations

Despite substantial degradation, 2‐arachidonoylglycerol is a potent full efficacy agonist mediating CB₁ receptor‐dependent G‐protein activation in rat cerebellar membranes

2001 • 154 citations

Local cooling of pre‐frontal cortex induces pacemaker‐like firing of dopamine neurons in rat ventral tegmental area in vivo

1989 • 151 citations

Novel selective and metabolically stable inhibitors of anandamide cellular uptake

2003 • 150 citations

Sub-second changes in accumbal dopamine during sexual behavior in male rats

2001 • 146 citations

Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens

2001 • 138 citations

Molecular biology of cannabinoid receptors

2002 • 137 citations

Endocannabinoids in cognition and dependence

2002 • 137 citations

Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor

2003 • 133 citations

Distinct cannabinoid sensitive receptors regulate hippocampal excitation and inhibition

2002 • 124 citations

Effects of long-term cannabis use on selective attention: An event-related potential study

1991 • 124 citations

Group I Metabotropic Glutamate Receptors Inhibit GABA Release at Interneuron-Purkinje Cell Synapses through Endocannabinoid Production

2004 • 114 citations

Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action

2000 • 97 citations

Antagonism of NMDA receptors but not AMPA/kainate receptors blocks bursting in dopaminergic neurons induced by electrical stimulation of the prefrontal cortex

1996 • 96 citations

Inositol 1,4,5-Triphosphate-Evoked Responses in Midbrain Dopamine Neurons

2000 • 82 citations

Brief Trains of Action Potentials Enhance Pyramidal Neuron Excitability Via Endocannabinoid-Mediated Suppression of Inhibition

2004 • 75 citations

Group I Metabotropic Glutamate Receptors Mediate an Inward Current in Rat Substantia Nigra Dopamine Neurons That Is Independent From Calcium Mobilization

1999 • 70 citations

A Slow Excitatory Postsynaptic Current Mediated by G‐protein‐coupled Metabotropic Glutamate Receptors in Rat Ventral Tegmental Dopamine Neurons

1997 • 60 citations

Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra.

1994 • 58 citations

Pharmacological Characterization of Synaptic Transmission through mGluRs in Rat Cerebellar Slices

1997 • 56 citations

Expression of metabotropic glutamate receptor 1 isoforms in the substantia nigra pars compacta of the rat

1998 • 55 citations

Functional Significance of Cannabinoid-Mediated, Depolarization-Induced Suppression of Inhibition (DSI) in the Hippocampus

2003 • 53 citations

Effects of 2-arachidonylglycerol, an endogenous cannabinoid, on neuronal activity in rat hippocampal slices

2000 • 50 citations

Two components of CA3 pyramidal neurons of the rat

1996 • 31 citations