The Atomic Mobility Component of Protein Antigenicity

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Principles of protein structure

1980 • 1,094 citations

Structure and mechanism of copper, zinc superoxide dismutase

1983 • 917 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

Structure and refinement of oxymyoglobin at 1·6 Å resolution

1980 • 641 citations

Correlation between segmental mobility and the location of antigenic determinants in proteins

1984 • 590 citations

Evolution of a Gene

1975 • 554 citations

Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

1983 • 540 citations

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

1984 • 485 citations

Cavities in proteins: structure of a metmyoglobin xenon complex solved to 1.9 .ANG.

1984 • 471 citations

Hydrophobic moments and protein structure

1982 • 434 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

The hinge-bending mode in lysozyme

1976 • 370 citations

Molecular dynamics of native protein

1983 • 358 citations

21 Vertebrate Lysozymes

1972 • 358 citations

A computer program for predicting protein antigenic determinants

1983 • 316 citations

Structural domains in proteins and their role in the dynamics of protein function

1983 • 283 citations

Structure of the semiquinone form of flavodoxin from Clostridium MP

1977 • 221 citations

Structural and functional diversity in 4-α-helical proteins

1980 • 213 citations

Tuna cytochrome c at 2.0 A resolution. I.Ferricytochrome structure analysis.

1977 • 201 citations

Structure of tomato bushy stunt virus IV

1983 • 200 citations

Functional significance of flexibility in proteins

1983 • 190 citations

Amino and carboxy-terminal regions in globular proteins

1983 • 187 citations

Structure of ribonuclease A: results of joint neutron and x-ray refinement at 2.0-.ANG. resolution

1983 • 173 citations

Primary Structure of Lysozymes from Man and Goose

1971 • 169 citations

Is the evolution of insulin Darwinian or due to selectively neutral mutation?

1975 • 151 citations

The dynamic picture of protein structure

1983 • 136 citations

ANTIBODIES TO A UNIQUE REGION IN LYSOZYME PROVOKED BY A SYNTHETIC ANTIGEN CONJUGATE

1969 • 124 citations

The immunological activity of some of the chymotryptic peptides of sperm-whale myoglobin

1965 • 114 citations

The precise and entire antigenic structure of native lysozyme

1978 • 114 citations

Structure of variant-3 scorpion neurotoxin from Centruroides sculpturatus ewing, refined at 1·8 Å resolution

1983 • 103 citations

Structural Studies of Ribonuclease. VII. Chymotryptic Hydrolysis of Ribonuclease A at Elevated Temperatures^*

1963 • 97 citations

Amino acid sequence of California quail lysozyme. Effect of evolutionary substitutions on the antigenic structure of lysozyme

1979 • 86 citations

Immunological Activity of Cytochrome c

1970 • 84 citations

Structurally inherent antigenic sites. Localization of the antigenic sites of the α-chain of human haemoglobin in three host species by a comprehensive synthetic approach

1982 • 81 citations

Structural dynamics of liganded myoglobin

1980 • 77 citations

Antigenic specificity of monoclonal antibodies to human myoglobin.

1982 • 77 citations

Evolutionary substitutions and the antigenic structure of globular proteins

1978 • 69 citations

Common precursor of lysozymes of hen egg-white and bacteriophage T4

1981 • 67 citations

Influence of solvent accessibility and intermolecular contacts on atomic mobilities in hemerythrins.

1985 • 67 citations

GRAMPS - A graphics language interpreter for real-time, interactive, three-dimensional picture editing and animation

1981 • 62 citations

The structure of mouse testicular lactate dehydrogenase isoenzyme C4 at 2.9 A resolution.

1979 • 61 citations

Ligand effects on organometallic substitution reactions

1983 • 60 citations

Preliminary crystallographic study of the complex between the Fab fragment of a monoclonal anti-lysozyme antibody and its antigen

1983 • 60 citations

Molecular dynamics of ferrocytochrome c

1980 • 58 citations

Prediction and conformation by synthesis of two antigenic sites in human haemoglobin by extrapolation from the known antigenic structure of sperm-whale myoglobin

1977 • 58 citations

Molecular features and immunological properties of lactate dehydrogenase C4 isozymes from mouse and rat testes.

1983 • 57 citations

How antigenic are antigenic peptides?

1983 • 56 citations

Specificity of the antibody response of rabbits to a self-antigen

1979 • 50 citations

Intrinsic stabilities of portions of the ribonuclease molecule

1980 • 48 citations

On topographic antigenic determinants in myoglobins

1980 • 47 citations

The primary structure of myohemerythrin

1976 • 47 citations

Adjustment of restraints in the refinement of methemerythrin and azidomethemerythrin at 2.0 Å resolution

1983 • 47 citations

The effect of a single amino acid substitution on the antigenic specificity of the loop region of lysozyme

1980 • 45 citations

Production of Monoclonal Antibodies to Surface Regions that are Non-Immunogenic in a Protein Using Free Synthetic Peptide as Immunogens: Demonstration with Sperm-Whale Myoglobin

1983 • 45 citations

Antibodies with specificities to preselected protein regions evoked by free synthetic peptides representing protein antigenic sites or other surface locations: Demonstration with myoglobin

1983 • 45 citations

Immunochemistry of scorpion α-neurotoxins. Determination of the antigenic site number and isolation of a highly enriched antibody specific to a single antigenic site of toxin II ofAndroctonus australis Hector

1983 • 44 citations

Experience with fast Fourier least squares in the refinement of the crystal structure of rhombohedral 2-zinc insulin at 1.5 Å resolution

1978 • 39 citations

The role of specific amino acid residues in the antigenic reactivity of the loop peptide of lysozyme

1973 • 38 citations

The detection of five antigenically reactive regions in the soybean leghemoglobin a molecule

1978 • 31 citations

Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides.

1985 • 29 citations

Immune recognition of cytochrome c. I. Investigation by synthesis whether antigenic sites of polymeric cytochrome coincide with locations of sequence differences between the immunizing and host cytochromes

1981 • 25 citations

Interaction of carboxypeptidase a with monoclonal antibodies

1984 • 24 citations

Characterization of monoclonal antibodies to the sperm-specific lactate dehydrogenase isozyme.

1983 • 21 citations

Cellular and humoral immune responses in guinea pigs and rabbits to chemically defined synthetic peptides

1973 • 17 citations

Structural analysis of insulin determinants seen by T cells directed by H-2 genes

1983 • 16 citations

Idiotypes on monoclonal antibodies to bovine insulin. I. Two public idiotypes on anti-bovine insulin hybridomas define idiotypically distinct families of hybridomas.

1983 • 15 citations

Identification of an idiotypic marker of a major regulatory T cell of the immune response in B10.BR mice to ferredoxin. The relationship of idiotypic regulation to conventional hapten-carrier effects.

1983 • 14 citations

Deuterium nuclear magnetic resonance of deuterium-labeled diacetyldeuterohemin incorporated into sperm whale myoglobin.

1975 • 14 citations

Antibodies specific for NADPH-binding region of enzymes possessing dehydrogenase activities.

1983 • 13 citations

Analysis of a Complex Antigenic Site on Horse Cytochrome c

1978 • 12 citations

The use of unideterminant fragments of ferredoxin in the genetic mapping of determinant specificity of the immune response

1982 • 10 citations

The Chemistry of Antigen-Antibody Union

1985 • 5 citations

Antigenic Determinants of Proteins and Synthetic Vaccines

1984 • 5 citations