The X-files in immunity: sex-based differences predispose immune responses

The Protective Effects of Estrogen on the Cardiovascular System

1999 • 3,003 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Sex differences in autoimmune disease

2001 • 1,233 citations

Sex hormones and the immune response in humans

2005 • 1,033 citations

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

2008 • 999 citations

The effects of hormones on sex differences in infection: from genes to behavior

2000 • 792 citations

Glycoprotein-D–Adjuvant Vaccine to Prevent Genital Herpes

2002 • 772 citations

Gonadal Steroids and Immunity*

1996 • 667 citations

Connections and Regulation of the Human Estrogen Receptor

2002 • 570 citations

Sex Differences in Pharmacokinetics and Pharmacodynamics

2004 • 491 citations

Sex-Associated Hormones and Immunity to Protozoan Parasites

2001 • 450 citations

Hurler and Hunter Syndromes: Mutual Correction of the Defect in Cultured Fibroblasts

1968 • 437 citations

Estrogen alters thresholds for B cell apoptosis and activation

2002 • 431 citations

Genetic control of the CD4/CD8 T-cell ratio in humans

1995 • 426 citations

Expansion of CD4+CD25+and FOXP3+ Regulatory T Cells during the Follicular Phase of the Menstrual Cycle: Implications for Human Reproduction

2007 • 419 citations

Estrogen alters thresholds for B cell apoptosis and activation

2002 • 387 citations

A role for sex chromosome complement in the female bias in autoimmune disease

2008 • 350 citations

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

2007 • 331 citations

PREGNANCY AND RHEUMATOID ARTHRITIS

1997 • 311 citations

The causes and effects of socio-demographic exclusions from clinical trials

2005 • 243 citations

Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood

2006 • 227 citations

Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)α and ERβ ligand treatment

2007 • 217 citations

CLINICAL DIAGNOSIS AND ASSESSMENT OF SEVERITY OF CONFIRMED DENGUE INFECTIONS IN VIETNAMESE CHILDREN: IS THE WORLD HEALTH ORGANIZATION CLASSIFICATION SYSTEM HELPFUL?

2004 • 207 citations

Cutting Edge: Cross-Regulation by TLR4 and T cell Ig Mucin-3 Determines Sex Differences in Inflammatory Heart Disease

2007 • 197 citations

17?-estradiol regulates cytokine release through modulation of CD16 expression in monocytes and monocyte-derived macrophages

2004 • 197 citations

Testosterone Treatment in Multiple Sclerosis

2007 • 194 citations

IPEX as a Result of Mutations in FOXP3

2007 • 191 citations

The Role of X Inactivation and Cellular Mosaicism in Women's Health and Sex-Specific Diseases

2006 • 174 citations

The group B coxsackieviruses and myocarditis

2001 • 169 citations

Skewed X chromosome inactivation in blood cells of women with scleroderma

2005 • 168 citations

17β-Estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells

2004 • 153 citations

Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats

2007 • 144 citations

Sex differences in the clinical, immunological and virological parameters of HIV-infected patients treated with HAART

2007 • 138 citations

Nonrandom inactivation of the X chromosome in early lineage hematopoietic cells in carriers of Wiskott-Aldrich syndrome

1995 • 137 citations

Effects of Sex Hormones on Chemotaxis of Human Peripheral Polymorphonuclear Leukocytes and Monocytes

1992 • 136 citations

A Yin-Yang Effect between Sex Chromosome Complement and Sex Hormones on the Immune Response

2005 • 134 citations

Sex issues in HIV-1-infected persons during highly active antiretroviral therapy: a systematic review

2007 • 123 citations

Estrogen Regulates CCR Gene Expression and Function in T Lymphocytes

2005 • 119 citations

Estrogen and CD4+ T cells

2007 • 118 citations

Sex differences in autoimmune disease

2006 • 118 citations

Sexual dimorphism in immune response genes as a function of puberty

2006 • 113 citations

Monocyte–Macrophage System as a Target for Estrogen and Selective Estrogen Receptor Modulators

2006 • 112 citations

Predominant type 1 CMV-Specific memory T-helper response in humans: evidence for gender differences in cytokine secretion

2004 • 105 citations

Antiretroviral pharmacokinetic profile: A review of sex differences

2007 • 100 citations

17β-Estradiol Alters the Activity of Conventional and IFN-Producing Killer Dendritic Cells

2008 • 99 citations

Estrogen Stimulates Neuronal Nitric Oxide Synthase Protein Expression in Human Neutrophils

1999 • 98 citations

Modulation of 17β-estradiol on the number and cytotoxicity of NK cells in vivo related to MCM and activating receptors

2007 • 97 citations

Plasma Sex Hormones and Aromatase Activity in Tissues of Patients with Systemic Lupus Erythematosus

1992 • 95 citations

Sex differences in susceptibility to viral infection of the central nervous system

1996 • 95 citations

Synovial fluid estrogens in rheumatoid arthritis

2003 • 94 citations

A novel X-linked combined immunodeficiency disease.

1990 • 86 citations

Sex and the course of HIV infection in the pre- and highly active antiretroviral therapy eras

2005 • 85 citations

Emergence and Persistence of Hantaviruses

2007 • 84 citations

Sex differences in coxsackievirus B3-induced myocarditis: IL-12Rβ1 signaling and IFN-γ increase inflammation in males independent from STAT4

2006 • 82 citations

Pregnancy Suppresses Experimental Autoimmune Encephalomyelitis through Immunoregulatory Cytokine Production

2007 • 71 citations

Hormones, pregnancy, and rheumatoid arthritis.

2002 • 65 citations

Cyclic Shedding of HIV‐1 RNA in Cervical Secretions during the Menstrual Cycle

2004 • 63 citations

Susceptibility of Human Female Primary Genital Epithelial Cells to Herpes Simplex Virus, Type-2 and the Effect of TLR3 Ligand and Sex Hormones on Infection1

2007 • 58 citations

Pregnancy and Multiple Sclerosis

2007 • 58 citations

Sex-Dependent Differences in Plasma Cytokine Responses to Hantavirus Infection

2008 • 52 citations

17β-Estradiol utilizes the estrogen receptor to regulate CD16 expression in monocytes

2007 • 51 citations

Sex Difference in the Serostatus of Adults to the Epstein-Barr Virus

1994 • 32 citations

Characterization of lymphocyte subsets over a 24-hour period in Pineal-Associated Lymphoid Tissue (PALT) in the chicken

2006 • 30 citations

Tissue-specific effect of estradiol on endothelial cell-dependent lymphocyte recruitment

2004 • 29 citations

Host factors mediating sex differences in viral infection

2005 • 24 citations

Immune consequences of mutations in the human common γ-chain gene

2002 • 22 citations

Are women appropriately represented and assessed in clinical trials submitted for marketing authorization? A review of the database of the European Medicines Agency

2007 • 18 citations

Is susceptibility to severe infection in low‐income countries inherited or acquired?

2007 • 15 citations

Evaluation of Sex Differences of Fosamprenavir (With and Without Ritonavir) in HIV-Infected Men and Women

2007 • 15 citations

A Rational Approach on the Use of Sex Steroids in Multiple Sclerosis

2008 • 10 citations