Degradation of human articular cartilage by neutrophils in synovial fluid

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid

1961 • 3,860 citations

An enzymic method for the trace iodination of immunoglobulins and other proteins

1969 • 1,414 citations

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

1987 • 823 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Elastase secretion by stimulated macrophages. Characterization and regulation.

1975 • 522 citations

The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

1971 • 513 citations

Secretion of a specific collagenase by stimulated macrophages.

1975 • 432 citations

Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor).

1981 • 390 citations

The Immunologic Release of Constituents from Neutrophil Leukocytes

1971 • 319 citations

The Effect of Synovial Tissue on the Breakdown of Articular Cartilage in Organ Culture

1977 • 312 citations

Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

1989 • 298 citations

The collagen substrate specificity of human neutrophil collagenase.

1987 • 285 citations

Biological effects of the human complement fragments C5a and C5ades Arg on neutrophil function

1980 • 265 citations

Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

1977 • 218 citations

Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis

1985 • 207 citations

The degradation of articular collagen by neutrophil proteinases

1977 • 189 citations

Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue.

1976 • 127 citations

CHARACTERIZATION OF THE "REACTANT" (GAMMA GLOBULIN FACTOR) IN THE F II PRECIPITIN REACTION AND THE F II TANNED SHEEP CELL AGGLUTINATION TEST

1958 • 119 citations

Correlated metabolism of proteoglycans and hyaluronic acid in bovine cartilage organ cultures.

1988 • 105 citations

Synovial collagenase: Its presence in culture from joint disease of diverse etiology

1969 • 83 citations

The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan heterogeneity and the pathway of proteolytic degradation

1977 • 80 citations

Interaction of polymorphonuclear leukocytes with immune complexes trapped in rheumatoid articular cartilage

1983 • 77 citations

Degradation of cartilage matrix proteoglycan by human neutrophils involves both elastase and cathepsin G.

1991 • 76 citations

Leucocyte infiltration and cartilage proteoglycan loss in immune arthritis in the rabbit

1988 • 71 citations

Interaction of polymorphonuclear leukocytes with immune complexes trapped in joint collagenous tissues

1979 • 54 citations

Mechanisms of human neutrophil‐mediated cartilage damage in vitro: The role of lysosomal enzymes, hydrogen peroxide and hypochlorous acid

1989 • 47 citations

Amino acid analysis of collagen hydrolysates by reverse-phase high-performance liquid chromatography of 9-fluorenylmethyl chloroformate derivatives

1990 • 47 citations

Activation of neutrophil collagenase by cathepsin G

1989 • 44 citations

Induction of neutrophil enzyme release by rheumatoid factors: Evidence for differences based on molecular characteristics

1986 • 37 citations

Immune deposits in articular cartilage of patients with rheumatoid arthritis have a granular pattern not seen in osteoarthritis

1990 • 26 citations

Additive enhancement of neutrophil collagenase activity by HOCl and cathepsin G

1992 • 24 citations

Ligand‐dependent release of active neutrophil collagenase

1990 • 21 citations

Immunorecognition of chondrocytes in articular cartilage activated by synovial interleukin 1

1991 • 12 citations

Lysis of fibrillar collagen by neutrophils in synovial fluid. A Role for Surface‐Bound Immunoglobulins

1990 • 12 citations

Agglutination of IgG‐coated particles by collagen

1979 • 11 citations

Role of PMN in early cartilage destruction

1991 • 6 citations

Interactions of immunoglobulins and chondrocytes.

1991 • 5 citations