Structural Enzymology of Li+-sensitive/Mg2+-dependent Phosphatases

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

1997 • 14,729 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

The development of versions 3 and 4 of the Cambridge Structural Database System

1991 • 1,299 citations

Improved R-factors for diffraction data analysis in macromolecular crystallography

1997 • 837 citations

Two‐Metal Ion Catalysis in Enzymatic Acyl‐ and Phosphoryl‐Transfer Reactions

1996 • 605 citations

Phi/Psi-chology: Ramachandran revisited

1996 • 550 citations

wARP: Improvement and Extension of Crystallographic Phases by Weighted Averaging of Multiple-Refined Dummy Atomic Models

1997 • 449 citations

Homology modeling, model and software evaluation: three related resources.

1998 • 348 citations

Lithium toxicity in yeast is due to the inhibition of RNA processing enzymes

1997 • 245 citations

Mechanisms of signaling and related enzymes

1997 • 243 citations

Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences

1991 • 223 citations

Mechanisms of signaling and related enzymes

1997 • 223 citations

A Salt-Sensitive 3′(2′),5′-Bisphosphate Nucleotidase Involved in Sulfate Activation

1995 • 203 citations

Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure.

1995 • 156 citations

Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene.

1993 • 143 citations

Structure of inositol monophosphatase, the putative target of lithium therapy.

1992 • 141 citations

The Yeast HAL2 Nucleotidase Is an in Vivo Target of Salt Toxicity

1996 • 138 citations

Chemical and kinetic mechanism of the inositol monophosphatase reaction and its inhibition by Li⁺

1993 • 91 citations

X-ray structure of yeast hal2p, a major target of lithium and sodium toxicity, and identification of framework interactions determining cation sensitivity

2000 • 74 citations

A Novel Mammalian Lithium-sensitive Enzyme with a Dual Enzymatic Activity, 3′-Phosphoadenosine 5′-Phosphate Phosphatase and Inositol-polyphosphate 1-Phosphatase

1999 • 68 citations

Stereochemical, mechanistic, and structural features of enzyme-catalysed phosphate monoester hydrolyses

1995 • 66 citations

Probing the role of metal ions in the mechanism of inositol monophosphatase by site‐directed mutagenesis

1993 • 60 citations

Crystal Structure and Catalytic Mechanism of the MJ0109 Gene Product: A Bifunctional Enzyme with Inositol Monophosphatase and Fructose 1,6-Bisphosphatase Activities^,

2001 • 54 citations

Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3′-phosphoadenosine-5′-phosphate phosphatase activities: a novel target of lithium therapy

2002 • 42 citations

3-Dimensional interactions between inositol monophosphatase and its substrates, inhibitors and metal ion cofactors

1995 • 22 citations

Probes for the position and mechanistic role of the second ‘catalytic’ magnesium ion in the inositol monophosphatase reaction

1995 • 19 citations

Inversion of Configuration during the Hydrolysis of <scp>d</scp>-1-S_p-myo-Inositol [¹⁷O]Thiophosphate Catalyzed by myo-Inositol Monophosphatase

1999 • 8 citations