Mechanisms of action of lipoxygenase and cytochrome P‐450‐mono‐oxygenase inhibitors in blocking endothelium‐dependent vasodilatation

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

1985 • 1,266 citations

The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs

1984 • 937 citations

Cyclic guanosine monophosphate as a mediator of vasodilation.

1986 • 811 citations

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

1985 • 685 citations

The nature of endothelium-derived vascular relaxant factor

1984 • 591 citations

A new approach to anti-inflammatory drugs

1979 • 501 citations

Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries.

1986 • 295 citations

2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone (AA861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis

1982 • 251 citations

Release and properties of endothelium‐derived relaxing factor (EDRF) from endothelial cells in culture

1985 • 230 citations

Mechanism of action of some inhibitors of endothelium-derived relaxing factor.

1986 • 218 citations

Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase

1983 • 202 citations

Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase

1969 • 185 citations

In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin

1983 • 155 citations

Purifieation of a Soluble, Sodium‐Nitroprusside‐Stimulated Guanylate Cyclase from Bovine Lung

1981 • 147 citations

The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat

1980 • 147 citations

1-phenyl-3-pyrazolidone: An inhibitor of cyclo-oxygenase and lipoxygenase pathways in lung and platelets

1978 • 139 citations

Species-dependent differences in the nature of endothelium-derived vascular relaxing factor

1984 • 114 citations

Effects of cimetidine and ranitidine on hepatic drug metabolism

1982 • 111 citations

Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor.

1986 • 80 citations

Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid.

1986 • 77 citations

Effects of Cytochrome P-450 Inhibitors on Endothelium-Dependent Relaxation in Rabbit Aorta

1984 • 76 citations

Endothelium-dependent relaxation of rabbit aorta. II. Inhibition of relaxation stimulated by methacholine and A23187 with antagonists of arachidonic acid metabolism.

1983 • 74 citations

The endothelium-dependent vasodilator effect of acetylcholine: Characterization of the endothelial relaxing factor with inhibitors of arachidonic acid metabolism

1984 • 73 citations

6,9-deepoxy-6,9,-(phenylimino)-delta 6,8-prostaglandin I1, (U-60,257), a new inhibitor of leukotriene C and D synthesis: in vitro studies.

1982 • 71 citations

Characterization of vascular relaxant factor released from cultured endothelial cells.

1987 • 71 citations

Presence of cytochrome P-450-dependent monooxygenase in intimal cells of the hog aorta.

1985 • 70 citations

Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells

1987 • 68 citations

Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases

1985 • 64 citations

Endothelium-dependent vasodilation by melittin: are lipoxygenase products involved?

1985 • 51 citations

Arachidonate 5-lipoxygenase and its new inhibitors

1984 • 45 citations

Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H₂-receptor blockers

1984 • 45 citations

Selective inhibition by gossypol of endothelium‐dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery

1987 • 43 citations

Inhibitors of Leukotriene Synthesis and Action

1984 • 22 citations

The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.

1972 • 22 citations

Modulation of guanylate cyclase by lipoxygenase inhibitors.

1986 • 18 citations