Evidence that Unrejoined DNA Double-Strand Breaks are not Predominantly Responsible for Chromosomal Radiosensitivity of AT Fibroblasts

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Karyotyping human chromosomes by combinatorial multi-fluor FISH

1996 • 1,265 citations

The Mechanism and Regulation of Chromosomal V(D)J Recombination

2002 • 931 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

Radiation-induced apoptosis: Relevance to radiotherapy

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Repair of Potentially Lethal Damage in X-Irradiated HeLa Cells¹

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Ataxia-telangiectasia and cellular responses to DNA damage.

1995 • 378 citations

A Quantitative Comparison of Potentially Lethal Damage Repair and the Rejoining of Interphase Chromosome Breaks in Low Passage Normal Human Fibroblasts

1987 • 329 citations

Repair of Potentially Lethal Damage in X-Irradiated HeLa Cells

1966 • 310 citations

On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia

1985 • 298 citations

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells

1980 • 260 citations

Cell Death, Chromosome Damage and Mitotic Delay in Normal Human, Ataxia Telangiectasia and Retinoblastoma Fibroblasts after X-irradiation

1981 • 220 citations

Repair of Sub-lethal and Potentially Lethal Radiation Damage in Plateau Phase Cultures of Human Cells

1969 • 212 citations

Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations

1978 • 209 citations

The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasia

1977 • 203 citations

Is chromatid-type damage in ataxia telangiectasia after irradiation at G0 a consequence of defective repair?

1976 • 197 citations

Fish “painting” patterns resulting from complex exchanges

1994 • 190 citations

Unusual levels of (ADP-ribose)n and DNA synthesis in ataxia telangiectasia cells following γ-ray irradiation

1980 • 175 citations

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

1998 • 160 citations

Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum

1978 • 159 citations

Measurement of DNA Double-strand Breaks in CHO Cells at Various Stages of the Cell Cycle Using Pulsed Field Gel Electrophoresis: Calibration by Means of¹²⁵I Decay

1991 • 157 citations

In vitro chromosomal radiosensitivity in “chromosomal breakage syndromes”

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Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations

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Complex Chromosome Exchanges Induced by Gamma Rays in Human Lymphocytes: An mFISH Study

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The rejoining of double-strand breaks in DNA by human cell extracts

1990 • 135 citations

Analyzing Radiation-Induced Complex Chromosome Rearrangements by Combinatorial Painting¹

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DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. I. Determination of Induced Breaks by Centrifugation at Reduced Speed

1982 • 123 citations

Radioresistant DNA synthesis: an intrinsic feature of ataxia telangiectasia

1981 • 117 citations

Ataxia-telangiectasia: founder effect among north African Jews

1996 • 108 citations

Effect of Confluent Holding on Potentially Lethal Damage Repair, Cell Cycle Progression, and Chromosomal Aberrations in Human Normal and Ataxia-Telangiectasia Fibroblasts

1985 • 104 citations

Induction and Rejoining of DNA Double-Strand Breaks and Interphase Chromosome Breaks after Exposure to X Rays in One Normal and Two Hypersensitive Human Fibroblast Cell Lines

1995 • 99 citations

Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts

1983 • 96 citations

Abnormal Radiosensitivity of Lymphocytes from Breast Cancer Patients with Excessive Normal Tissue Damage after Radiotherapy: Chromosome Aberrations after Low Dose-rate Irradiation

1995 • 94 citations

Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia (AT) fibroblasts

1985 • 92 citations

Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe

2000 • 92 citations

Dose-response curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridization

1996 • 88 citations

Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages

1979 • 86 citations

Cellular Radiosensitivity in Ataxia-telangiectasia

1994 • 84 citations

Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation

1995 • 82 citations

Detection of incomplete exchanges and interstitial fragments in X-irradiated human lymphocytes using a telomeric PNA probe

1998 • 79 citations

Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents

1980 • 76 citations

Radiosensitivity of Ataxia Telangiectasia and Nijmegen Breakage Syndrome Homozygotes and Heterozygotes as Determined by Three-Color FISH Chromosome Painting

2002 • 76 citations

Estimating the True Frequency of X-ray-induced Complex Chromosome Exchanges Using Fluorescencein SituHybridization

1995 • 76 citations

Chromosome Instability Syndromes: Lessons for Carcinogenesis

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Chromosome Instability Syndromes

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Chromosomal breakage syndromes

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Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes

1998 • 69 citations

Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts

2000 • 67 citations

Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints

1998 • 60 citations

Estimation of minimal size of translocated chromosome segments detectable by fluorescence in situ hybridization

1997 • 58 citations

Prediction of human cell radiosensitivity: Comparison of clonogenic assay with chromosome aberrations scored using premature chromosome condensation with fluorescence in situ hybridization

1994 • 54 citations

A multifaceted role for ATM in genome maintenance

2003 • 51 citations

Effect of Dose Rate on the Survival of Irradiated Human Skin Fibroblasts

1992 • 46 citations

Human normal peripheral blood B-lymphocytes are deficient in DNA-dependent protein kinase activity due to the expression of a variant form of the Ku86 protein

1998 • 45 citations

Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: possible role of apoptosis

1995 • 44 citations

Detection of Ataxia Telangiectasia Heterozygous Cell Lines by Postirradiation Cumulative Labeling Index: Measurements with Coded Samples

1987 • 42 citations

Comparison of γ-radiation-induced accumulation of ataxia telangiectasia and control cells in G2 phase

1989 • 40 citations

Structural changes in chromatin as the basis for radiosensitivity in ataxia telangiectasia

1982 • 39 citations

Clustering of radiation-produced breaks along chromosomes: modelling the effects on chromosome aberrations

1999 • 38 citations

X-ray-induced simple, pseudosimple and complex exchanges involving two distinctly painted chromosomes

1999 • 35 citations

Influence of ATM Function on Interactions between Telomeres and Nuclear Matrix¹

2000 • 30 citations

Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors

1997 • 29 citations

Identification of X-ray-induced Complex Chromosome Exchanges Using Fluorescencein SituHybridization: A Comparison at Two Doses

1994 • 26 citations

Possible Role of Chromatin Alteration in the Radiosensitivity of Ataxia-telangiectasia

1994 • 24 citations

Radiation-induced chromosome breaks in ataxia-telangiectasia cells remain open

2003 • 19 citations

Radiation-Induced Chromosome Aberrations in Ataxia Telangiectasia Cells: High Frequency of Deletions and Misrejoining Detected by FluorescenceIn SituHybridization

2003 • 16 citations

Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein

2000 • 5 citations

TEL1 from Saccharomyces cerevisiae suppresses chromosome aberrations induced by ionizing radiation in ataxia-telangiectasia cells without affecting cell cycle checkpoints

2001 • 4 citations

Cellular radiosensitivity tn ataxia-telangiectasia

1994 • 4 citations