Structure-pharmacokinetics relationship of quaternary ammonium compounds

Methods in enzymology, vol. 174

1991 • 1,216 citations

Intestinal permeation

1978 • 192 citations

Renal tubule transport of organic cations

1981 • 156 citations

Quantitative structure-pharmacokinetic relationships and drug design

1981 • 147 citations

Functional group behaviour in ion-pair reversed-phase high-performance liquid chromatography using surface- active pairing ions

1979 • 121 citations

Renal tubular excretion of organic bases.

1960 • 113 citations

Pharmacokinetic concepts ? Drug binding, apparent volume of distribution and clearance

1981 • 90 citations

Regional blood flows measured in conscious rats by combined Fick and microsphere methods

1978 • 87 citations

Quantitaton of rate of gastrointestinal and buccal absorption of acidic and basic drugs based on extraction theory

1973 • 83 citations

Lipophilicity and drug activity

1979 • 79 citations

Estimation of aqueous solubilities of organic non-electrolytes using liquid chromatographic retention data

1981 • 69 citations

Hepatic drug transport in the rat

1982 • 57 citations

Biliary excretion of some diquaternary ammonium cations in the rat, guinea pig and rabbit

1973 • 57 citations

Molecular weight as a factor in the excretion of monoquaternary ammonium cations in the bile of the rat, rabbit and guinea pig

1973 • 54 citations

Intestinal absorption-partition relationships: A tentative functional nonlinear model

1981 • 50 citations

Structure-pharmacokinetics relationship of quaternary ammonium compounds

1984 • 49 citations

[4] Collection of metabolites in bile and urine from the rat

1981 • 44 citations

Hepatic uptake and biliary excretion of d-tubocurarine and trimethyltubocurarine in the rat in vivo and in isolated perfused rat livers.

1976 • 35 citations

Tissue distribution kinetics of tetraethylammonium ion in the rat

1980 • 32 citations

Pharmacokinetic Aspects of Elimination from Plasma and Distribution to Brain and Liver of Barbiturates in Rat

1973 • 26 citations

Choleresis and hepatic transport mechanisms

1978 • 25 citations

Quantitative structure–activity relationships in drug metabolism and disposition: Pharmacokinetics of N-substituted amphetamines in humans

1980 • 20 citations

The Physicochemical Factor Required for the Biliary Excretion of Organic Cations and Anions

1974 • 20 citations

Partition of Alkylsulfates of Quaternary Ammonium Compounds: Structure Dependence and Transport Study

1970 • 20 citations

Automated pharmacokinetic analysis: Experiences of a user

1982 • 15 citations

Transport rates of hepatic uptake and biliary excretion of an organic cation, acetyl procainamide ethobromide

1980 • 10 citations

Metabolic Disposition of Emepronium in the Dog with a Note on the Relationship between Plasma Concentration and Effect

1971 • 9 citations

Studies on the pharmacokinetics of bis-quaternary ammonium compounds

1972 • 9 citations

Hepatic Disposition and Biliary Excretion of the Organic Cations Thiazinamium and Thiazinamium Sulfoxide in Rats

1978 • 8 citations

The development of induced cervicovaginal carcinoma in intact and estrogen-treated, castrated mice studied by histochemical and enzyme histochemical methods.

1966 • 8 citations

Transport of quaternary ammonium-alkyl sulfate and sodium salicylate across rat small intestine.

1973 • 6 citations

Pharmacokinetic study on saturated hepato-biliary transport of acetyl procainamide ethobromide.

1981 • 5 citations