Intestinal Permeation of Organic Bases and Quaternary Ammonium Compounds

The Distinction by Means of Tracers Between Active Transport and Diffusion

1949 • 674 citations

The gastric secretion of drugs: a pH partition hypothesis.

1957 • 466 citations

On the mechanism of intestinal absorption of drugs.

1959 • 447 citations

Non-ionic diffusion and the excretion of weak acids and bases

1958 • 377 citations

Absorption of drugs from the rat small intestine.

1958 • 362 citations

Beiträge zur allgemeinen Muskel- und Nervenphysiologie

1902 • 327 citations

Absorption of drugs from the stomach. I. The rat.

1957 • 270 citations

Passage of drugs across body membranes.

1962 • 262 citations

SOME ASPECTS OF CELL PERMEABILITY TO WEAK ELECTROLYTES

1940 • 237 citations

Intestinal permeation

1978 • 192 citations

Absorption of drugs from the stomach. II. The human.

1957 • 181 citations

Renal tubule transport of organic cations

1981 • 156 citations

On the Mechanism of Absorption of Drugs from the Gastrointestinal Tract

1960 • 132 citations

ABSORPTION AND DISTRIBUTION OF DRUGS

1963 • 123 citations

Significance of sodium ions in active intestinal transport of nonelectrolytes

1961 • 122 citations

Transport of organic ions in renal cortical luminal and antiluminal membrane vesicles.

1979 • 118 citations

Mechanisms of organic cation transport in kidney plasma membrane vesicles: 2. delta pH studies.

1981 • 115 citations

Renal tubular excretion of organic bases.

1960 • 113 citations

Absorption and Distribution of Drugs

1964 • 112 citations

Experiments on the absorption of organic solutes in the small intestine of rats

1937 • 94 citations

Paraquat disposition in rats, guinea pigs and monkeys

1974 • 94 citations

Absorption of drugs from the rat colon.

1959 • 87 citations

Active transport of quaternary ammonium compounds by the choroid plexus in vitro

1965 • 80 citations

Active transport of some pyrimidines across the rat intestinal epithelium.

1960 • 78 citations

Intestinal absorption and malabsorption

1969 • 75 citations

Factors influencing the intestinal absorption of certain monoquaternary anticholinergic compounds with special reference to benzomethamine [N-diethylaminoethyl-N'-methylbenzilamide methobromide (MC-3199)].

1955 • 74 citations

The influence of experimental procedures and dose on the intestinal absorption of an onium compound, benzomethamine.

1961 • 67 citations

Mechanisms of organic cation transport in kidney plasma membrane vesicles: 1. Countertransport studies.

1980 • 64 citations

Enhancement of Gastrointestinal Absorption of a Quaternary Ammonium Compound by Trichloroacetate

1969 • 60 citations

Entry and distribution of hexamethonium in the central nervous system

1971 • 55 citations

Secretion of purines by the small intestine: general characteristics

1968 • 55 citations

Interaction between intestinal absorption and secretion of monoquaternary ammonium compounds in guinea pigs--a concept for the absorption kinetics of organic cations.

1980 • 52 citations

Absorption and secretion of monoquaternary ammonium compounds by the isolated intestinal mucosa

1977 • 50 citations

Paraquat poisoning in man

1975 • 48 citations

Excretion of Drugs in Bile

1971 • 43 citations

Intestinal Transport of Weak Electrolytes

1974 • 41 citations

Some characteristics of the pyrimidine transport process of the small intestine

1962 • 41 citations

Intestinal Absorption and Malabsorption

1976 • 41 citations

Amino acid transport by the small intestine of the rat

1965 • 40 citations

Intestinal absorption of choline in the chick

1973 • 39 citations

Renal Transport of Organic Substances

1981 • 38 citations

THE INFLUENCE OF THE HYDROGEN ION CONCENTRATION ON THE ABSORPTION OF ALKALOIDS FROM THE STOMACH

1940 • 38 citations

Transport of organic cations and anions by choroid plexus.

1976 • 38 citations

Physiological transport of drugs.

1964 • 37 citations

Interaction of purines with the pyrimidine transport process of the small intestine

1963 • 37 citations

Passive permeabilities of luminal and basolateral membranes in the isolated mucosal epithelium of guinea pig small intestine

1977 • 37 citations

Studies on the uptake of N'-methylnicotinamide by renal slices of the dog.

1959 • 35 citations

Choline influx across the brush border of guinea pig jejunum

1977 • 35 citations

Absorption of protein digestion products.

1974 • 34 citations

RENAL TUBULAR SECRETION AND REABSORPTION OF ORGANIC BASES IN THE DOG*

1962 • 33 citations

Fate of emepronium in man in relation to its pharmacological effects

1973 • 33 citations

Intestinal transport of weak electrolytes: Determinants of influx at the luminal surface.

1978 • 33 citations

Relations of weak-electrolyte transport and acid-base metabolism in rat small intestine in vitro

1975 • 32 citations

Intestinal Secretion of Erythromycin Base

1976 • 31 citations

The physiological disposition of oxyphenonium bromide (antrenyl) and related compounds.

1957 • 30 citations

The chemical transformations of dibenamine and dibenzyline and biological activity.

1953 • 29 citations

Inhibition of the renal tubular excretion of tetraethylammonium and N'-methylnicotinamide by basic cyanine dyes.

1956 • 29 citations

The physiological disposition of hexamethonium and related compounds.

1960 • 28 citations

The influence of the intraluminal intestinal milieu on absorption of an organic cation and an anionic agent.

1961 • 26 citations

Excretion of Drugs by the Kidney

1971 • 26 citations

Absorption, distribution and excretion of [14C]CTAB, a quaternary ammonium surfactant, in the rat

1975 • 25 citations

Absorption of Drugs from the Gastrointestinal Tract

1971 • 25 citations

Active absorption of hypoxanthine by lamb jejunum in vitro

1981 • 25 citations

Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine

1976 • 24 citations

The binding of organic bases to kidney cortex slices.

1969 • 23 citations

Secretion of monoquaternary ammonium compounds by guinea pig small intestine in vivo

1977 • 22 citations

Intestinal Absorption and Secretion of Cardiac Glycosides

1981 • 21 citations

Intestinal Absorption of Pralidoxime and other Aldoximes

1966 • 20 citations

The Physicochemical Factor Required for the Biliary Excretion of Organic Cations and Anions

1974 • 20 citations

An in vitro study of the intestinal absorption of pyridinium aldoximes

1969 • 19 citations

Adenosine uptake by the isolated epithelium of guinea pig jejunum

1977 • 19 citations

Metabolismus und enterale Resorption herzwirksamer Glykoside

1969 • 19 citations

Weak electrolyte permeation in alimentary epithelia

1981 • 19 citations

The uptake of hexamethonium-C14 by kidney slices.

1965 • 18 citations

On the Metabolic Disposition of Methylatropine in Animals and Man

1969 • 16 citations

Secretion of purines by the small intestine: transport mechanism

1968 • 16 citations

Intestinal Secretion of Sulphanilic Acid by the Isolated Mucosa of Guinea Pig Jejunum

1978 • 16 citations

Renal Tubular Transport of Organic Cations

1981 • 15 citations

Uptake of quaternary ammonium compounds into rat intestinal brush border membrane vesicles

1981 • 14 citations

Studies of the renal tubular transport characteristics of N1-methylnicotinamide and tetraalkylammonium compounds in the avian kidney.

1959 • 14 citations

Die enterale Sekretion kardiotoner Steroide — Untersuchungen zum Mechanismus des Resorptionsvorganges

1969 • 13 citations

Contribution to the intestinal absorption of ergot peptide alkaloids

1980 • 13 citations

Inhibitory effects of beta-haloalkylamines on the renal transport of N-methylnicotinamide.

1968 • 13 citations

Variations in the bioavailability of thiazinamium methylsulfate

1977 • 13 citations

Weak-acid transport in the small intestine: Discrimination in the lamina propria

1981 • 11 citations

INHIBITION OF THE RENAL TUBULAR EXCRETION OF N1-METHYLNICOTINAMIDE (NMN) IN THE AVIAN KIDNEY BY A CYANINE DYE AND BY BISQUATERNARY COMPOUNDS

1960 • 11 citations

Intestinal absorption, intestinal distribution, and excretion of [14C] labelled hyoscine N-butyl bromide (butylscopolamine) in the rat

1973 • 11 citations

Intestinal transfer of the quaternary ammonium compound N-methyl-scopolamine by two transport mechanisms in series

1977 • 11 citations

Inhibition of the renal tubular excretion of N'-methylnicotinamide (NMN) by small doses of a basic cyanine dye.

1955 • 11 citations

Active secretion of hypoxanthine and xanthine by guinea pig jejunum in vitro

1980 • 10 citations

In vivo absorption studies with paraquat and diquat in the dog [proceedings].

1976 • 10 citations

The intestinal absorption of scopolamine-n-butylbromide (Buscopan®) from isolated loops in conscious rats

1969 • 10 citations

The Gastrointestinal Absorption of Anticholinergic Drugs: Comparison between Individuals

1971 • 10 citations

The reversible and irreversible inhibition of N1-methylnicotinamide uptake into rat kidney cortex slices.

1968 • 9 citations

Werden quatern�re Ammoniumverbindungen �ber einen enteralen Sekretionsmechanismus resorbiert?

1970 • 9 citations

The Structure of N-Methyl-pyridinium-2-aldoxime.

1962 • 9 citations

Enteral absorption of hyoscine N-butylbromide

1967 • 9 citations

Hepatic Disposition and Biliary Excretion of the Organic Cations Thiazinamium and Thiazinamium Sulfoxide in Rats

1978 • 8 citations

Renal Transport of Drugs

1981 • 8 citations

Intestinal absorption of a monoquaternary drug,14C-neostigmine

1971 • 8 citations

Absorption of paraquat by rat gut in vitro

1979 • 8 citations

The intestinal absorption of the quaternary derivatives of atropine and scopolamine.

1959 • 8 citations

Uptake in the human small intestine of a quaternary anticholinergic compound (Acabel)

1971 • 7 citations

[Metabolism and intestinal absorption of cardiac glycosides].

1969 • 7 citations

Absorption and Excretion of Drugs. XLI. Studies on the Gastrointestinal Absorption of 2-Pyridine Aldoxime Methiodide and Its Derivatives.

1969 • 7 citations

Gastrointestinal secretion and absorption of 3-methylaminoisocamphane hydrochloride (mecamylamine).

1958 • 7 citations

BIODYNAMICS OF THIOUREA-ALKALOID COMBINATIONS.

1963 • 7 citations

Inhibition of the renal tubular transport of N1-methylnicotinamide (NMN) by 1,1-dialkylpiperidinium compounds in the avian kidney.

1959 • 6 citations

Epithelial transport of weak electrolytes.

1979 • 6 citations

Epithelial transport of weak electrolytes. Properties of a model of the three compartment system

1977 • 5 citations

Absorption of14C-methylscopolamine from the digestive tract

1971 • 5 citations

Effect of choline on tetraethylammonium transport in mouse kidney cortex slices

1977 • 5 citations

A note on the intestinal absorption of penthienate (monodral).

1957 • 3 citations

[Apropos of the intestinal absorption of N-butyl hyoscine].

1969 • 3 citations

Die enterale Sekretion kardiotoner Steroide — Untersuchungen zum Mechanismus des Resorptionsvorganges / The Intestinal Secretion of Cardiotonic Steroids—Investigations on the Absorption Mechanism

1969 • 3 citations

Rectal absorption of homatropine [14C]methylbromide in the rat

1978 • 2 citations

Investigations on the Intestinal Secretion of Drugs by the Isolated Mucosa of Guinea-Pig Colon

1978 • 2 citations

Asymmetry of Membrane Functions in Transporting Cells

1981 • 1 citations

Effect of some cationic drugs on the intestinal absorption of pralidoxime iodide.

1975 • 1 citations