Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition.

1990 • 1,291 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family

1999 • 806 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

A proinflammatory role for IL-18 in rheumatoid arthritis

1999 • 629 citations

Revised criteria for diagnosis of coeliac disease

1990 • 562 citations

Purification and Characterization of the Human Interleukin-18 Receptor

1997 • 471 citations

Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).

1999 • 462 citations

Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease

1998 • 460 citations

Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.

1988 • 404 citations

Bioactive IL-18 Expression Is Up-Regulated in Crohn’s Disease

1999 • 399 citations

Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma.

1995 • 346 citations

Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling

1998 • 326 citations

IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes.

1998 • 306 citations

Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells.

1998 • 272 citations

Caspase-1-Independent, Fas/Fas Ligand–Mediated IL-18 Secretion from Macrophages Causes Acute Liver Injury in Mice

1999 • 245 citations

IFN-α and IL-12 Induce IL-18 Receptor Gene Expression in Human NK and T Cells

2000 • 169 citations

The costimulatory effect of IL-18 on the induction of antigen-specific IFN-γ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor β2 subunit

2000 • 160 citations

Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease

2001 • 147 citations

T cells orchestrate intestinal mucosal shape and integrity

1999 • 126 citations

The pathogenesis of celiac disease

1998 • 115 citations

Chlamydia trachomatis Infection of Epithelial Cells Induces the Activation of Caspase-1 and Release of Mature IL-18

2000 • 107 citations

Spontaneous secretion of interferon γ and interleukin 4 by human intraepithelial and lamina propria gut lymphocytes

1998 • 96 citations

Expression of Interleukin‐18, a Th1 Cytokine, in Human Gastric Mucosa Is Increased inHelicobacter pyloriInfection

2001 • 93 citations

Human Peyer’s Patch T Cells Are Sensitized to Dietary Antigen and Display a Th Cell Type 1 Cytokine Profile

2000 • 92 citations

Gluten Stimulation of Coeliac Mucosa In Vitro Induces Activation (CD25) of Lamina Propria CD4^H T cells and Macrophages but no Crypt‐Cell Hyperplasia

1993 • 90 citations

Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts.

1997 • 87 citations

FAS engagement drives apoptosis of enterocytes of coeliac patients

2001 • 83 citations

Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia.

1998 • 78 citations

Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract

2000 • 38 citations

Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.

2000 • 36 citations

Expression of interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection

2003 • 4 citations