A Carboxyl-terminal Extension of the Zinc Finger Domain Contributes to the Specificity and Polarity of Peroxisome Proliferator-activated Receptor DNA Binding

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Structural determinants of nuclear receptor assembly on DNA direct repeats

1995 • 561 citations

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.

1994 • 485 citations

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.

1992 • 454 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

1993 • 394 citations

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

1994 • 380 citations

Polarity and Specific Sequence Requirements of Peroxisome Proliferator-activated Receptor (PPAR)/Retinoid X Receptor Heterodimer Binding to DNA

1997 • 342 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

1992 • 312 citations

Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding

1993 • 296 citations

Novel Sequence Determinants in Peroxisome Proliferator Signaling

1995 • 285 citations

Peroxisome Proliferator-Activated Receptors and Retinoic Acid Receptors Differentially Control the Interactions of Retinoid X Receptor Heterodimers with Ligands, Coactivators, and Corepressors

1997 • 279 citations

PPAR-RXR Heterodimer Activates a Peroxisome Proliferator Response Element Upstream of the Bifunctional Enzyme Gene

1993 • 265 citations

The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.

1994 • 251 citations

Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.

1992 • 233 citations

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

1993 • 218 citations

Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.

1994 • 210 citations

The Monomer-Binding Orphan Receptor Rev-Erb Represses Transcription as a Dimer on a Novel Direct Repeat

1995 • 204 citations

Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation

1993 • 199 citations

The Orphan Receptor Rev-ErbAα Activates Transcription via a Novel Response element

1993 • 199 citations

Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene

1991 • 198 citations

Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.

1994 • 194 citations

Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription

1995 • 185 citations

Role of the peroxisome proliferator‐activated receptor in cytochrome P450 4A gene regulation

1996 • 178 citations

Determinants of Target Gene Specificity for RORα1: Monomeric DNA Binding by an Orphan Nuclear Receptor

1995 • 121 citations

A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb.

1994 • 116 citations

Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator.

1994 • 109 citations

Transcriptional Activation and Repression by RORα, an Orphan Nuclear Receptor Required for Cerebellar Development

1997 • 95 citations

The Nonconserved Hinge Region and Distinct Amino-Terminal Domains of the RORα Orphan Nuclear Receptor Isoforms are Required for Proper DNA Bending and RORα-DNA Interactions

1995 • 92 citations

[1] Maximizing expression of eukaryotic cytochrome P450s in Escherichia coli

1996 • 88 citations

Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.

1994 • 85 citations

Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.

1994 • 77 citations

Identification of an extended half‐site motif required for the function of peroxisome proliferator‐activated receptor α

1997 • 48 citations

Cooperative Formation of Higher Order Peroxisome Proliferator-activated Receptor and Retinoid X Receptor Complexes on the Peroxisome Proliferator Responsive Element of the Rat Hydratase-Dehydrogenase Gene

1995 • 47 citations

Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells.

1998 • 47 citations

A single amino acid change in the mouse peroxisome proliferator-activated receptor alpha alters transcriptional responses to peroxisome proliferators.

1995 • 46 citations

Specificity and mechanism of thyroid hormone induction from an octamer response element.

1994 • 46 citations

The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs

1995 • 19 citations

[1] Purification of viral polymerases: General considerations

1996 • 4 citations