Positive and Negative Modulation of Vitamin D Receptor Function by Transforming Growth Factor-β Signaling through Smad Proteins

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1998 • 714 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

25-Hydroxyvitamin D ₃ 1α-Hydroxylase and Vitamin D Synthesis

1997 • 528 citations

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

1998 • 516 citations

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

1999 • 442 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members

1998 • 355 citations

Isoforms of steroid receptor co-activator 1differ in their ability to potentiate transcription by the oestrogen receptor

1998 • 321 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7

1998 • 240 citations

Induction of Smad6 mRNA by Bone Morphogenetic Proteins

1998 • 168 citations

Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-β in human normal lung epithelial cells

1998 • 164 citations

Intron Retention Generates a Novel Isoform of the Murine Vitamin D Receptor That Acts in a Dominant Negative Way on the Vitamin D Signaling Pathway

1996 • 82 citations

Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements.

1996 • 62 citations

1α,25-Dehydroxyvitamin D3 Synergism toward Transforming Growth Factor-β1-induced AP-1 Transcriptional Activity in Mouse Osteoblastic Cells via Its Nuclear Receptor

1998 • 35 citations

Transforming growth factor β-induced dissociation between vitamin D receptor level and 1,25-dihydroxyvitamin D3 action in osteoblast-like cells

1994 • 21 citations