Sit4 Is Required for Proper Modulation of the Biological Functions Mediated by Pkc1 and the Cell Integrity Pathway inSaccharomyces cerevisiae

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Three new dominant drug resistance cassettes for gene disruption inSaccharomyces cerevisiae

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The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog.

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Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.

1996 • 499 citations

The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.

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Genome‐wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway

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A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae

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The SIT4 protein phosphatase functions in late G1 for progression into S phase.

1991 • 340 citations

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

1999 • 339 citations

Regulatory Mechanisms for Modulation of Signaling through the Cell Integrity Slt2-mediated Pathway in Saccharomyces cerevisiae

2000 • 337 citations

Dominant Mutations in a Gene Encoding a Putative Protein Kinase (BCKT) Bypass the Requirement for a Saccharomyces cerevisiae Protein Kinase C Homolog

1992 • 322 citations

Wsc1 and Mid2 Are Cell Surface Sensors for Cell Wall Integrity Signaling That Act through Rom2, a Guanine Nucleotide Exchange Factor for Rho1

2001 • 306 citations

MKK1 and MKK2, Which Encode Saccharomyces cerevisiae Mitogen-Activated Protein Kinase-Kinase Homologs, Function in the Pathway Mediated by Protein Kinase C

1993 • 306 citations

Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae.

1994 • 290 citations

Cell Wall Stress Depolarizes Cell Growth via Hyperactivation of Rho1

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A Second Osmosensing Signal Transduction Pathway in Yeast

1995 • 278 citations

Cell wall perturbation in yeast results in dual phosphorylation of the Slt2/Mpk1 MAP kinase and in an Slt2-mediated increase in FKS2–lacZ expression, glucanase resistance and thermotolerance

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Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity.

1996 • 266 citations

Saccharomyces cerevisiae Mid2p Is a Potential Cell Wall Stress Sensor and Upstream Activator of the PKC1-MPK1 Cell Integrity Pathway

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A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases

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SBF Cell Cycle Regulator as a Target of the Yeast PKC-MAP Kinase Pathway

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Osmotic stress and the yeast cytoskeleton: phenotype-specific suppression of an actin mutation.

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The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast.

1996 • 243 citations

Spa2p Interacts with Cell Polarity Proteins and Signaling Components Involved in Yeast Cell Morphogenesis

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Temperature-Induced Expression of Yeast FKS2 Is under the Dual Control of Protein Kinase C and Calcineurin

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A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants

1991 • 197 citations

The Cln3 cyclin is down-regulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeast

1997 • 175 citations

The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton

1998 • 157 citations

The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation

1996 • 155 citations

Activity of the yeast MAP kinase homologue Slt2 is critically required for cell integrity at 37° C

1993 • 149 citations

Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC

1994 • 147 citations

SIT4 protein phosphatase is required for the normal accumulation of SWI4, CLN1, CLN2, and HCS26 RNAs during late G1.

1992 • 144 citations

Repression of Ribosome and tRNA Synthesis in Secretion-Defective Cells Is Signaled by a Novel Branch of the Cell Integrity Pathway

2000 • 129 citations

A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway.

1993 • 127 citations

Heterologous URA3MX cassettes for gene replacement inSaccharomyces cerevisiae

1999 • 126 citations

Heat Shock-Mediated Cell Cycle Blockage and G1 Cyclin Expression in the Yeast Saccharomyces cerevisiae

1993 • 119 citations

Activation of CLN1 and CLN2 G₁ Cyclin Gene Expression by BCK2

1995 • 108 citations

Differential Regulation of the Cell Wall Integrity Mitogen-Activated Protein Kinase Pathway in Budding Yeast by the Protein Tyrosine Phosphatases Ptp2 and Ptp3

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Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization.

1995 • 97 citations

Mutations in the Saccharomyces cerevisiae Type 2A Protein Phosphatase Catalytic Subunit Reveal Roles in Cell Wall Integrity, Actin Cytoskeleton Organization and Mitosis

1997 • 96 citations

Osmotic stress causes a G₁ cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae

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Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae

2000 • 83 citations

The Yeast Ser/Thr Phosphatases Sit4 and Ppz1 Play Opposite Roles in Regulation of the Cell Cycle

1999 • 79 citations

Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants.

1995 • 78 citations

Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosis.

1993 • 76 citations

Molecular cloning and analysis of a yeast protein phosphatase with an unusual amino-terminal region.

1992 • 71 citations

The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.

1995 • 63 citations

Drosophila protein phosphatase V functionally complements a SIT4 mutant in Saccharomyces cerevisiae and its amino-terminal region can confer this complementation to a heterologous phosphatase catalytic domain.

1993 • 52 citations

LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth.

1995 • 51 citations

Regulation of Monovalent Ion Homeostasis and pH by the Ser-Thr Protein Phosphatase SIT4 in Saccharomyces cerevisiae

2000 • 45 citations

The Cak1p Protein Kinase Is Required at G1/S and G2/M in the Budding Yeast Cell Cycle

1997 • 35 citations

Elutriation of budding yeast

1997 • 24 citations

Dominant Mutations of Drosophila MAP Kinase Kinase and Their Activities in Drosophila and Yeast MAP Kinase Cascades

1997 • 16 citations