The inflammatory function of renal glomerular mesangial cells and their interaction with the cellular immune system

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.

1990 • 555 citations

Physiology of the mesangial cell

1989 • 484 citations

Involvement of IL-6 in mesangial proliferative glomerulonephritis.

1989 • 415 citations

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

1990 • 338 citations

A mononuclear cell component in experimental immunological glomerulonephritis.

1978 • 317 citations

Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis.

1988 • 311 citations

Leukocyte analysis using monoclonal antibodies in human glomerulonephritis

1987 • 300 citations

Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat.

1991 • 293 citations

Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells

1990 • 286 citations

Role of reactive oxygen metabolites in experimental glomerular disease

1989 • 276 citations

Increased synthesis of extracellular matrix in mesangial proliferative nephritis

1991 • 265 citations

Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies. A sequential histological and ultrastructural study in the rat.

1986 • 262 citations

Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor.

1990 • 205 citations

Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis.

1990 • 199 citations

The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation. Contributions of adhesion and co-activation.

1991 • 197 citations

ELEVATED EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA AND PROTEOGLYCAN PRODUCTION IN EXPERIMENTAL GLOMERULONEPHRITIS

1990 • 196 citations

Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.

1991 • 195 citations

Interleukin 6 is an autocrine growth factor for mesangial cells

1990 • 194 citations

Mesangial cells express PDGF mRNAs and proliferate in response to PDGF

1988 • 191 citations

Intraglomerular T cells and monocytes in nephritis: Study with monoclonal antibodies

1987 • 181 citations

Reactive oxygen production by cultured rat glomerular mesangial cells during phagocytosis is associated with stimulation of lipoxygenase activity.

1983 • 180 citations

Mechanisms of glomerular injury in immune-complex disease

1985 • 172 citations

Interleukin 1 and the glomerular mesangium. I. Purification and characterization of a mesangial cell-derived autogrowth factor.

1986 • 164 citations

Transforming growth factor β2 inhibits interleukin 1β- and tumour necrosis factor α-induction of nitric oxide synthase in rat renal mesangial cells

1991 • 162 citations

Accessory Cell Signals Involved in T‐Cell Activation

1990 • 160 citations

Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells.

1991 • 159 citations

The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis.

1987 • 159 citations

Prostaglandin modulation of development of cell-mediated immunity in culture

1980 • 159 citations

T-cells and macrophages in rapidly progressive glomerulonephritis: Clinicopathologic correlations

1987 • 159 citations

Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis.

1991 • 154 citations

Functional expression of NADPH oxidase components (alpha- and beta-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells.

1991 • 146 citations

Autoreactive T cells in mercury-induced autoimmunity. Ability to induce the autoimmune disease.

1988 • 139 citations

T lymphocyte participation in antibody-induced experimental glomerulonephritis

1985 • 138 citations

Activation of glomerular mesangial cells by the terminal membrane attack complex of complement.

1987 • 135 citations

PARTICIPATION OF CELL-MEDIATED IMMUNITY IN DEPOSITION OF FIBRIN IN GLOMERULONEPHRITIS

1988 • 126 citations

Novel and enhanced IL-1 gene expression in autoimmune mice with lupus.

1988 • 126 citations

Constitutive expression of endothelin gene in cultured human mesangial cells and its modulation by transforming growth factor-beta, thrombin, and a thromboxane A2 analogue.

1991 • 124 citations

Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit.

1991 • 123 citations

Endogenous non-cyclooxygenase metabolites of arachidonic acid modulate growth and mRNA levels of immediate-early response genes in rat mesangial cells

1991 • 122 citations

Interleukin 1: more than a mediator between leukocytes

1988 • 120 citations

Production of platelet-derived growth factorlike protein by rat mesangial cells in culture.

1987 • 110 citations

Demonstration of PDGF B-chain mRNA in glomeruli in mesangial proliferative nephritis by in situ hybridization

1991 • 110 citations

Preferential binding of oxidized LDL to rat glomeruli in vivo and cultured mesangial cells in vitro

1991 • 105 citations

Immune complexes bind to cultured rat glomerular mesangial cells to stimulate superoxide release. Evidence for an Fc receptor.

1987 • 100 citations

Contribution of mononuclear leucocytes to the progression of experimental focal glomerular sclerosis

1990 • 99 citations

Mesangial cell accessory functions: Mediation by intercellular adhesion molecule-1

1990 • 97 citations

Platelets mediate neutrophil-dependent immune complex nephritis in the rat.

1988 • 95 citations

The presence and possible role of monocyte infiltration in human chronic proliferative glomerulonephritides. Light microscopic, immunofluorescence, and histochemical correlations.

1979 • 87 citations

A cell-mediated reaction against glomerular-bound immune complexes.

1979 • 87 citations

Possible regulatory functions of protein kinase C-α and -ε isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis

1991 • 87 citations

Autoreactive T cells in mercury-induced autoimmune disease: in vitro demonstration.

1986 • 86 citations

Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells.

1991 • 85 citations

Interleukin-1β stimulates human mesangial cells to synthesize and release interleukins-6 and -8

1991 • 83 citations

Mitogenic effect of platelet-derived growth factor in human glomerular mesangial cells: modulation and/or suppression by inflammatory cytokines

1991 • 83 citations

Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex. VII. Immune-complex glomerulonephritis.

1983 • 80 citations

Glomerular interleukin 1 production is dependent on macrophage infiltration in anti-GBM glomerulonephritis

1991 • 78 citations

Glomeruli synthesize nitrite in active Heymann nephritis; the source is infiltrating macrophages

1991 • 76 citations

Glomerular mesangial cells in local inflammation. Induction of the expression of MHC class II antigens by IFN-gamma.

1989 • 73 citations

Studies of the mitogenic effect of serotonin in rat renal mesangial cells

1989 • 73 citations

The prognostic significance of urinary interleukin 6 in IgA nephropathy.

1991 • 73 citations

Synthesis and Binding of Insulin-Like Growth Factor I by Human Glomerular Mesangial Cells*

1989 • 73 citations

Regulation of human mesangial cell growth in culture by thromboxane A2 and prostacyclin

1990 • 69 citations

Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells

1986 • 68 citations

Activated (IL-2R+) intraglomerular mononuclear cells in crescentic glomerulonephritis

1991 • 68 citations

Mononuclear cells in acute allograft glomerulopathy.

1987 • 67 citations

Transfer of experimental glomerulonephritis in chickens by mononuclear cells

1988 • 63 citations

Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells.

1988 • 62 citations

Monokines and platelet-derived growth factor modulate prostanoid production in growth arrested, human mesangial cells

1990 • 62 citations

Insulinlike growth factor-1 is a progression factor for human mesangial cells.

1989 • 62 citations

Interleukin I and the glomerular mesangium. II. Monokine stimulation of mesangial cell prostanoid secretion.

1987 • 60 citations

Functional characteristics of macrophages in glomerulonephritis in the rat. O2- generation, MHC class II expression, and eicosanoid synthesis.

1989 • 59 citations

Regulation of Mesangial Cell Proliferation

1991 • 58 citations

Monoclonal antibody analysis of glomerular hypercellularity in human glomerulonephritis.

1984 • 58 citations

Autoreactive T cells in mercury‐induced autoimmunity. Demonstration by limiting dilution analysis

1988 • 58 citations

Synthesis and release of insulinlike growth factor I by mesangial cells in culture

1988 • 56 citations

The mesangium and glomerulonephritis

1982 • 56 citations

Glomerular nitrite synthesis in in situ immune complex glomerulonephritis in the rat.

1991 • 54 citations

Mouse mesangial cells produce colony-stimulating factor-1 (CSF-1) and express the CSF-1 receptor.

1990 • 54 citations

Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1

1991 • 50 citations

Effector mechanisms in organ-specific autoimmunity. I. Characterization of a CD8+ T cell line that mediates murine interstitial nephritis.

1991 • 48 citations

Mesangial cell immune injury. Synthesis, origin, and role of eicosanoids.

1991 • 47 citations

Lymphokine (MIF) production by glomerular T-lymphocytes in experimental glomerulonephritis

1986 • 46 citations

Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor synthesis in rat mesangial cells

1991 • 43 citations

Mononuclear Leukocytes, Expression of HLA Class II Antigens and Intercellular Adhesion Molecule 1 in Focal Segmental Glomerulosclerosis

1991 • 42 citations

Serotonin and the glomerular mesangium. Mechanisms of intracellular signaling.

1991 • 41 citations

Cell-Mediated Immunity in Glomerular Disease

1991 • 41 citations

PDGF suppresses the activation of group II phospholipase A₂ gene expression by interleukin I and forskolin in mesangial cells

1991 • 41 citations

Increased class I and class II MHC products and mRNA in kidneys of MRL-lpr/lpr mice during autoimmune nephritis and inhibition by cyclosporine.

1988 • 40 citations

T cell receptor V_β genes expressed by IgG anti‐DNA autoantibody‐inducing T cells in lupus nephritis: Forbidden receptors and double‐negative T cells

1990 • 39 citations

Polyclonal activation and experimental nephropathies

1988 • 38 citations

Cyclosporin A in the prevention and treatment of experimental autoimmune glomerulonephritis in the brown Norway rat

1991 • 38 citations

Platelet-derived growth factor inhibits cytokine induction of nitric oxide synthase in rat renal mesangial cells

1991 • 38 citations

Increased expression of class II major histocompatibility complex molecules on B cells in rats susceptible or resistant to HgC12-induced autoimmunity

1991 • 37 citations

Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease.

1991 • 37 citations

Proteinases and the glomerulus: Their role in glomerular diseases

1990 • 37 citations

Mononuclear-cell subsets in human idiopathic crescentic glomerulonephritis (ICGN): Analysis in tissue sections with monoclonal antibodies

1984 • 37 citations

Effect of prostaglandin E2 on the γ-interferon induction of antigen-presenting ability in P388D1 cells and on IL-2 production by T-cell hybridomas

1985 • 35 citations

Immune recognition and response to the renal interstitium

1991 • 34 citations

T cell regulation, anti-idiotypic immunity, and the nephritogenic immune response

1983 • 33 citations

Biphasic effect of oxygen radicals on prostaglandin production by rat mesangial cells

1987 • 32 citations

Desferrioxamine regulates tumor necrosis factor release in mesangial cells

1991 • 30 citations

Mesangial cell activation by bacterial endotoxin. Induction of rapid cytoskeletal reorganization and gene expression.

1991 • 29 citations

Prostaglandin E1 suppresses macrophage infiltration and ameliorates injury in an experimental model of macrophage-dependent glomerulonephritis

1990 • 29 citations

Mechanisms underlying the anti-inflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis. Inhibited release of a monocyte chemoattractant by glomeruli.

1990 • 28 citations

Activation of glomerular mesangial cells by gram-negative bacterial cell wall components.

1988 • 27 citations

Treatment of murine immune complex glomerulonephritis with prostaglandin E2: Dose-response of immune complex deposition, antibody synthesis, and glomerular damage

1983 • 26 citations

Activation of MHC-restricted rat T cells by cloned syngeneic thyrocytes.

1988 • 26 citations

Autoimmunity in rapidly progressive glomerulonephritis

1989 • 26 citations

Effect of prostaglandin E1 treatment on murine acute immune complex glomerulonephritis

1980 • 25 citations

Interferon gamma-mediated renal MHC expression in mercuric chloride-induced glomerulonephritis

1991 • 25 citations

Relevance of experimental models for human nephropathology

1989 • 23 citations

Regulatory functions of protein kinase c in glomerular mesangial cells

1990 • 20 citations

Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid

1992 • 20 citations

Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor

1989 • 20 citations

Additive and synergistic effects of cyclosporine metabolites on glomerular mesangial cells

1991 • 20 citations

Murine interstitial nephritis. VII. Suppression of renal injury after treatment with soluble suppressor factor TsF1.

1987 • 18 citations

Murine interstitial nephritis. IX. Induction of the nephritogenic effector T cell repertoire with an antigen-specific T cell cytokine.

1990 • 18 citations

Experimental strategies for the study of cellular immunity in renal disease

1986 • 13 citations

Effects of PGE2 and a thromboxane A2 analogue on uptake of IgG complexes and LDL by mesangial cells

1991 • 12 citations

Contributions of mesangial cells to glomerular immune functions

1990 • 12 citations

Analysis of T cells and major histocompatibility complex class I and class II mRNA and protein content and distribution in antiglomerular basement membrane disease in the rabbit.

1991 • 10 citations

Complement and leukocyte independent proteinuria and eicosanoid synthesis in rat membranous nephropathy.

1988 • 8 citations

New concepts of glomerular injury.

1984 • 8 citations

Recent progress in renal immunopathology

1988 • 7 citations

Differential biological activities of human interleukin-1 alpha and interleukin-1 beta.

1991 • 5 citations

T lymphocyte participation in acute serum sickness glomerulonephritis in rabbits

1991 • 5 citations

Modulation of glomerular mesangial cell growth and prostaglandin release by T-lymphocyte products

1991 • 5 citations

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