Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease

A family of human cdc2-related protein kinases.

1992 • 928 citations

Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells

1992 • 741 citations

Neurofilament gene expression: a major determinant of axonal caliber.

1987 • 705 citations

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1993 • 550 citations

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis

1993 • 549 citations

Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice

1970 • 525 citations

Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton.

1984 • 496 citations

Neurofilaments are obligate heteropolymers in vivo

1993 • 387 citations

Self-assembly in vitro of the 68,000 molecular weight component of the mammalian neurofilament triplet proteins into intermediate-sized filaments

1981 • 288 citations

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression.

1992 • 275 citations

Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments

1993 • 270 citations

Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments.

1992 • 246 citations

Purification and characterization of a novel proline-directed protein kinase from bovine brain.

1992 • 238 citations

Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing

1988 • 230 citations

Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene.

1993 • 226 citations

Dynamics of neuronal intermediate filaments: A developmental perspective

1992 • 219 citations

Pathology of amyotrophic lateral sclerosis.

1982 • 209 citations

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

1993 • 207 citations

Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M

1993 • 203 citations

Purification of individual components of the neurofilament triplet: filament assembly from the 70000-dalton subunit

1982 • 201 citations

Cytopathology of amyotrophic lateral sclerosis.

1991 • 192 citations

Glycosylation

1992 • 186 citations

Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit.

1990 • 173 citations

Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber.

1990 • 166 citations

Reduced diameter and conduction velocity of myelinated fibers in the sciatic nerve of a neurofilament-deficient mutant quail

1993 • 163 citations

The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation.

1993 • 161 citations

Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules.

1991 • 140 citations

Hereditary hypotrophic axonopathy with neurofilament deficiency in a mutant strain of the Japanese quail

1991 • 131 citations

Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M.

1990 • 116 citations

Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation by tau protein kinase II.

1993 • 110 citations

Dynamics of the neuronal intermediate filaments.

1993 • 103 citations

Defective expression of neurofilament protein subunits in hereditary hypotrophic axonopathy of quail.

1992 • 71 citations

Effects of truncated neurofilament proteins on the endogenous intermediate filaments in transfected fibroblasts

1991 • 50 citations

Antibody labeling of bovine neurofilaments: implications on the structure of neurofilament sidearms*1

1991 • 41 citations

Identification and characterization of a novel (115 kDa) neurofilament- associated kinase

1994 • 33 citations

Chemical cross-linking analyses of ox neurofilaments

1986 • 22 citations