Interplay between the DNA Damage Proteins MDC1 and ATM in the Regulation of the Spindle Assembly Checkpoint

The spindle-assembly checkpoint in space and time

2007 • 2,120 citations

A quantitative atlas of mitotic phosphorylation

2008 • 1,566 citations

Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

2004 • 1,178 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

On the road to cancer: aneuploidy and the mitotic checkpoint

2005 • 1,162 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks

2005 • 1,036 citations

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

2005 • 1,034 citations

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

2004 • 979 citations

Molecular architecture of the kinetochore–microtubule interface

2007 • 891 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

DNA damage checkpoints: from initiation to recovery or adaptation

2007 • 755 citations

The Spindle Assembly Checkpoint

2012 • 716 citations

Stuck in Division or Passing through

2004 • 630 citations

MDC1 is required for the intra-S-phase DNA damage checkpoint

2003 • 508 citations

Timing and Checkpoints in the Regulation of Mitotic Progression

2004 • 468 citations

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

2004 • 395 citations

ATM Activation and DNA Damage Response

2007 • 378 citations

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

2004 • 337 citations

Dynamics of Centromere and Kinetochore Proteins

2004 • 264 citations

Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

2009 • 244 citations

Recombinant ATM protein complements the cellular A-T phenotype

1997 • 242 citations

Chk1 Is Required for Spindle Checkpoint Function

2007 • 230 citations

Structural and Functional Versatility of the FHA Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2

2002 • 228 citations

DNA Damage during Mitosis in Human Cells Delays the Metaphase/Anaphase Transition via the Spindle-Assembly Checkpoint

2002 • 216 citations

Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells

2001 • 214 citations

The Chromatin Response to DNA Breaks: Leaving a Mark on Genome Integrity

2013 • 128 citations

NFBD1/MDC1 regulates ionizing radiation‐induced focus formation by DNA checkpoint signaling and repair factors

2003 • 124 citations

Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain

2009 • 120 citations

Early events in the mammalian response to DNA double-strand breaks

2008 • 117 citations

NFBD1/KIAA0170 Is a Chromatin-associated Protein Involved in DNA Damage Signaling Pathways

2003 • 115 citations

Dynamics of Centromere and Kinetochore ProteinsImplications for Checkpoint Signaling and Silencing

2004 • 113 citations

Centrosomal localization of DNA damage checkpoint proteins

2006 • 110 citations

The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions

2010 • 106 citations

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

2011 • 103 citations

p53 Localization at Centrosomes during Mitosis and Postmitotic Checkpoint Are ATM-dependent and Require Serine 15 Phosphorylation

2004 • 97 citations

The cellular response to DNA damage: A focus on MDC1 and its interacting proteins

2010 • 97 citations

The spindle checkpoint

2006 • 96 citations

MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres

2006 • 93 citations

Mad2 Prolongs DNA Damage Checkpoint Arrest Caused by a Double-Strand Break via a Centromere-Dependent Mechanism

2010 • 92 citations

MDC1: The art of keeping things in focus

2010 • 91 citations

Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1

2006 • 86 citations

Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis

2011 • 78 citations

Kinetochore-microtubule interactions “in check” by Bub1, Bub3 and BubR1: The dual task of attaching and signalling

2008 • 77 citations

ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development

2005 • 76 citations

Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint

2007 • 75 citations

The cellular response to DNA damage: A focus on MDC1 and its interacting proteins

2010 • 71 citations

Modulation of Cellular Response to Anticancer Treatment by Caffeine: Inhibition of Cell Cycle Checkpoints, DNA Repair and More

2008 • 70 citations

ATM is Activated by Default in Mitosis, Localizes at Centrosomes and Monitors Mitotic Spindle Integrity

2005 • 69 citations

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63

2009 • 61 citations

The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents

2009 • 57 citations

Mitotic DNA damage response: Polo-like Kinase-1 is dephosphorylated through ATM-Chk1 pathway

2010 • 56 citations

Defective control of apoptosis, radiosensitivity, and spindle checkpoint in ataxia telangiectasia.

1998 • 55 citations

The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond

2008 • 50 citations

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling

2009 • 50 citations

Mediator of DNA Damage Checkpoint 1 (MDC1) Regulates Mitotic Progression

2009 • 49 citations

Centromeres: Old tales and new tools

2008 • 39 citations

Kinetochore-Microtubule Interactions

2008 • 21 citations

NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells

2010 • 14 citations

ATM-mediated NuSAP phosphorylation induces mitotic arrest

2010 • 14 citations