DNA-PKcs activates the Chk2–Brca1 pathway during mitosis to ensure chromosomal stability

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Cell Sensitivity Assays: The MTT Assay

2011 • 2,039 citations

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

2013 • 1,458 citations

A mechanism linking extra centrosomes to chromosomal instability

2009 • 1,368 citations

The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer

2010 • 1,140 citations

BRCA1 and BRCA2: 1994 and beyond

2004 • 941 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Chromosomal passengers: conducting cell division

2007 • 789 citations

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

1996 • 777 citations

Mechanisms of Chromosomal Instability

2010 • 560 citations

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

2006 • 544 citations

The role of chromosomal instability in tumor initiation

2002 • 543 citations

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

1998 • 515 citations

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

2002 • 462 citations

BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.

2003 • 383 citations

Microtubule-organizing centres: a re-evaluation

2007 • 382 citations

Sensing centromere tension: Aurora B and the regulation of kinetochore function

2010 • 358 citations

BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells

2003 • 354 citations

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

2009 • 341 citations

Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

2003 • 316 citations

Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks

2005 • 312 citations

BRCA1 is associated with the centrosome during mitosis

1998 • 311 citations

BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number

2004 • 287 citations

Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break

2006 • 284 citations

CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?

2007 • 282 citations

Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms

2003 • 266 citations

Merotelic kinetochore attachment: causes and effects

2011 • 244 citations

The Chk2 protein kinase

2004 • 239 citations

Chromosomal instability and cancer: a complex relationship with therapeutic potential

2012 • 237 citations

Merotelic kinetochore orientation, aneuploidy, and cancer

2008 • 212 citations

Polo-like Kinase 1 and Chk2 Interact and Co-localize to Centrosomes and the Midbody

2003 • 155 citations

BRCA1 Downregulation Leads to Premature Inactivation of Spindle Checkpoint and Confers Paclitaxel Resistance

2006 • 155 citations

The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

2010 • 149 citations

Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view

2009 • 135 citations

The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells

2008 • 118 citations

Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

2006 • 118 citations

Centrosomal Microtubule Nucleation Activity Is Inhibited by BRCA1-Dependent Ubiquitination

2005 • 118 citations

Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice

2009 • 107 citations

Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining

2006 • 105 citations

Inactivation of DNA-Dependent Protein Kinase Leads to Spindle Disruption and Mitotic Catastrophe with Attenuated Checkpoint Protein 2 Phosphorylation in Response to DNA Damage

2010 • 101 citations

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment.

2012 • 90 citations

The spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes

2008 • 81 citations

Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis

2011 • 78 citations

Role of BRCA1 in cellular resistance to paclitaxel and ionizing radiation in an ovarian cancer cell line carrying a defective BRCA1

2003 • 74 citations

Aurora-A Kinase Regulates Breast Cancer–Associated Gene 1 Inhibition of Centrosome-Dependent Microtubule Nucleation

2007 • 65 citations

The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer

2005 • 64 citations

Identification of Domains of BRCA1 Critical for the Ubiquitin-Dependent Inhibition of Centrosome Function

2006 • 58 citations

Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer

2007 • 43 citations

The BRCA1‐dependent ubiquitin ligase, γ‐tubulin, and centrosomes

2009 • 39 citations

Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase

2008 • 36 citations

BRCA1 is regulated by Chk2 in response to spindle damage

2008 • 31 citations

Loss of DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Expression in Gastric Cancers

2005 • 29 citations

Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability

2010 • 27 citations

The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer

2011 • 18 citations

[Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance].

2007 • 16 citations

The Spindle Checkpoint and Chromosomal Stability

2006 • 11 citations