Effect of oxidant stress in calcium signaling in vascular endothelial cells

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells

1973 • 1,303 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

Endothelium and control of vascular function. State of the Art lecture.

1989 • 661 citations

Calcium pump of the plasma membrane

1991 • 659 citations

Sarcoplasmic Reticulum

1964 • 654 citations

Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor

1989 • 531 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Fluid Flow Stimulates Tissue Plasminogen Activator Secretion by Cultured Human Endothelial Cells

1989 • 448 citations

The release of platelet-activating factor from human endothelial cells in culture.

1983 • 436 citations

Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.

1988 • 421 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential

1990 • 343 citations

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

1982 • 303 citations

Bradykinin-induced increases in cytosolic calcium and ionic currents in cultured bovine aortic endothelial cells.

1987 • 292 citations

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers.

1986 • 289 citations

Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells.

1987 • 281 citations

Agonist‐stimulated divalent cation entry into single cultured human umbilical vein endothelial cells.

1990 • 280 citations

Biosynthesis of endothelium-derived relaxing factor: A cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase

1989 • 271 citations

Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury.

1985 • 268 citations

Relationship between tissue plasminogen activator and the activators in blood and vascular wall

1980 • 254 citations

Regulation of cytosolic free calcium in fura-2-loaded rat parotid acinar cells.

1987 • 245 citations

Self-regulation of procoagulant events on the endothelial cell surface.

1985 • 231 citations

Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells.

1986 • 225 citations

Characterization of the Bradykinin-stimulated Calcium Influx Pathway of Cultured vascular Endothelial Cells

1989 • 224 citations

Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts

1990 • 204 citations

Exogenous ATP raises cytoplasmic free calcium in fura‐2 loaded piglet aortic endothelial cells

1986 • 200 citations

Thrombin-stimulated elevation of human endothelial-cell cytoplasmic free calcium concentration causes prostacyclin production

1988 • 190 citations

Depletion of the inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ store in vascular endothelial cells activates the agonist-sensitive Ca2+-influx pathway

1992 • 190 citations

Cytoskeletal and morphologic impact of cellular oxidant injury.

1986 • 190 citations

Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

1978 • 188 citations

Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs

1991 • 187 citations

Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin.

1982 • 182 citations

Polyphosphoinositide hydrolysis in endothelial cells and carotid artery segments. Bradykinin-2 receptor stimulation is calcium-independent.

1986 • 181 citations

Severe generalized glutathione reductase deficiency after antitumor chemotherapy with BCNU" [1,3-bis(chloroethyl)-1-nitrosourea].

1977 • 176 citations

Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione.

1983 • 176 citations

Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells

1987 • 175 citations

Sulfhydryl oxidation induces rapid calcium release from sarcoplasmic reticulum vesicles.

1986 • 175 citations

Critical role of sulfhydryl group(s) in ATP‐dependent Ca²⁺ sequestration by the plasma membrane fraction from rat liver

1983 • 172 citations

Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances

1991 • 171 citations

Inhibition of hepatocyte plasma membrane Ca²⁺‐ATPase activity by menadione metabolism and its restoration by thiols

1985 • 168 citations

Low Level Chemiluminescence of Liver Microsomal Fractions Initiated by tert‐Butyl Hydroperoxide

1982 • 165 citations

Reactive oxygen injury to cultured pulmonary artery endothelial cells: Mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance

1991 • 156 citations

Effects of an Imprinting Procedure on RNA Polymerase Activity in the Chick Brain

1970 • 154 citations

A direct electron spin resonance and spin-trapping investigation of peroxyl free radical formation by hematin/hydroperoxide systems.

1983 • 149 citations

Oscillatory cytosolic calcium waves independent of stimulated inositol 1,4,5-trisphosphate formation in hepatocytes

1991 • 144 citations

The agonist-sensitive calcium pool in the pancreatic acinar cell. Activation of plasma membrane Ca2+ influx mechanism.

1987 • 142 citations

Voltage-activated potassium, but not calcium currents in cultured bovine aortic endothelial cells

1987 • 142 citations

Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells.

1984 • 140 citations

Differential effects of hydrogen peroxide on indices of endothelial cell function.

1984 • 138 citations

Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool

1992 • 135 citations

Effects of bradykinin and angiotensin II on intracellular Ca2+ dynamics in endothelial cells

1987 • 133 citations

Membrane potential and Na(+)-K+ pump activity modulate resting and bradykinin-stimulated changes in cytosolic free calcium in cultured endothelial cells from bovine atria.

1990 • 126 citations

Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase

1991 • 123 citations

Oxidant-mediated activation of phospholipase A2 in pulmonary endothelium

1989 • 116 citations

Inhibition of erythrocyte Ca2+-ATPase by activated oxygen through thiol- and lipid-dependent mechanisms

1986 • 113 citations

Production of a fibrinolytic inhibitor by cultured endothelial cells derived from human umbilical vein

1978 • 111 citations

Enhancement of intracellular glutathione protects endothelial cells against oxidant damage

1985 • 110 citations

Bradykinin‐evoked changes in cytosolic calcium and membrane currents in cultured bovine pulmonary artery endothelial cells.

1989 • 108 citations

External ATP triggers a biphasic activation process of a calcium-dependent K+ channel in cultured bovine aortic endothelial cells

1988 • 105 citations

Bradykinin and inositol 1,4,5-trisphosphate-stimulated calcium release from intracellular stores in cultured bovine endothelial cells

1989 • 103 citations

Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids

1988 • 100 citations

Nitroxides block DNA scission and protect cells from oxidative damage

1991 • 94 citations

Angiogenin activates endothelial cell phospholipase C.

1988 • 88 citations

Nature of Thrombin-induced Sustained Increase in Cytosolic Calcium Concentration in Cultured Endothelial Cells

1989 • 85 citations

Bradykinin-stimulated calcium influx in cultured bovine aortic endothelial cells

1988 • 78 citations

Refill status of the agonist-sensitive Ca2+ pool regulates Mn2+ influx into parotid acini.

1990 • 78 citations

Blockade of endothelium-dependent relaxation by the amiloride analog dichlorobenzamil: possible role of Na+/Ca++ exchange in the release of endothelium-derived relaxant factor.

1985 • 78 citations

Effect of membrane potential on cytosolic calcium of bovine aortic endothelial cells

1989 • 77 citations

Oxidant- and lipid-induced pulmonary vasoconstriction mediated by arachidonic acid metabolites

1983 • 77 citations

DNA Strand Break Formation Following Exposure of Bovine Pulmonary Artery and Aortic Endothelial Cells to Reactive Oxygen Products

1991 • 75 citations

Effects of sulfhydryl reagents and other inhibitors on Ca2+ transport and inositol trisphosphate-induced Ca2+ release from human platelet membranes.

1986 • 72 citations

Lipid peroxidation and hemoglobin degradation in red blood cells exposed to t-butyl hydroperoxideDependence on glucose metabolism and hemoglobin status

1981 • 72 citations

Expression of I-region-associated antigen (Ia) and interleukin 1 by subcultured human endothelial cells

1985 • 72 citations

A simple and sensitive method for monitoring drug-induced cell injury in cultured cells

1985 • 72 citations

On the inter-relationship between glucagon action, the oxidation-reduction state of pyridine nucleotides, and calcium retention by rat liver mitochondria.

1980 • 71 citations

Endothelial nitric oxide generating enzyme(s) in the bovine aorta: subcellular location and metabolic characterization.

1990 • 67 citations

Mechanisms of Endothelial Cell ATP Depletion after Oxidant Injury

1989 • 66 citations

Effects of pH, Reducing and Alkylating Reagents on the Binding and Ca²⁺Release Activities of Inositol 1,4,5-Triphosphate in the Bovine Adrenal Cortex

1988 • 66 citations

Effect of membrane potential on divalent cation transport catalyzed by the “electroneutral” ionophores A23187 and ionomycin

1989 • 66 citations

Hyperoxia reduces plasma membrane fluidity: a mechanism for endothelial cell dysfunction

1986 • 64 citations

Progressive oxidative membrane damage in erythrocytes after pulse treatment with t-butylhydroperoxide

1987 • 63 citations

Effect of t-Butyl-hydroperoxide on Bradykinin-stimulated Changes in Cytosolic Calcium in Vascular Endothelial Cells

1989 • 63 citations

H2O2-mediated cytotoxicity of rat pulmonary endothelial cells. Changes in adenosine triphosphate and purine products and effects of protective interventions.

1990 • 60 citations

Possible participation of membrane thiol groups on the mechanism of NAD(P)+-stimulated Ca2+ efflux from mitochondria

1984 • 60 citations

Alterations in human vascular endothelial cell function by oxygen free radicals. Platelet adherence and prostacyclin release.

1991 • 59 citations

Mechanisms of oxygen free radical-induced calcium overload in endothelial cells.

1990 • 57 citations

Oxidant stress alters Na+ pump and Na(+)-K(+)-Cl- cotransporter activities in vascular endothelial cells

1992 • 55 citations

Effect of superoxide and lipid peroxide on cytosolic free calcium concentration in cultured pig aortic endothelial cells

1988 • 54 citations

Endothelium-derived relaxing factor release associated with increased endothelial cell inositol trisphosphate and intracellular calcium

1988 • 54 citations

Calcium Channel Activation Does Not Increase Release of Endothelial-Derived Relaxant Factors (EDRF) in Rat Aorta Although Tonic Release of EDRF May Modulate Calcium Channel Activity in Smooth Muscle

1986 • 53 citations

Alterations in inositol phosphate production during oxidative stress in isolated hepatocytes.

1987 • 53 citations

GTP gamma S loading of endothelial cells stimulates phospholipase C and uncouples ATP receptors

1988 • 51 citations

Regulation of endothelial cell prostaglandin synthesis by glutathione.

1991 • 49 citations

Role of sodium-calcium exchange and effects of calcium entry blockers on endothelial-mediated responses in rat isolated aorta.

1986 • 46 citations

Oxidants, ATP depletion, and endothelial permeability to macromolecules

1990 • 45 citations

Absence of effect of calcium antagonists on endothelium‐dependent relaxation in rabbit aorta

1987 • 44 citations

Ischemia/reperfusion-induced changes in membrane fluidity characteristics of brain capillary endothelial cells and its prevention by liposomal-incorporated superoxide dismutase

1991 • 44 citations

A critical appraisal of the association between energy charge and cell damage

1989 • 43 citations

Glutathione protects against exogenous oxidant injury to rabbit renal proximal tubules

1988 • 42 citations

Bradykinin-activated calcium influx pathway in bovine aortic endothelial cells

1992 • 40 citations

The effect of bcnu (carmustine) on tissue glutathione reductase activity

1983 • 40 citations

Release of nitrogen oxides from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists.

1991 • 40 citations

Membrane depolarization selectively inhibits receptor-operated calcium channels in human T (Jurkat) lymphoblasts

1990 • 35 citations

Voltage dependence of bovine pulmonary artery endothelial cell function*1

1991 • 35 citations

GTP_γS Increases Thrombin-mediated Inositol Trisphosphate Accumulation in Permeabilized Human Endothelial Cells

1989 • 34 citations

Mechanism of protection of oxidant-injured endothelial cells by glutamine.

1990 • 32 citations

Reactive disulfide compounds induce Ca2+ release from cardiac sarcoplasmic reticulum

1990 • 32 citations

Vasopressin-stimulated Ca2+ influx in rat hepatocytes is inhibited in high-K+ medium

1989 • 32 citations

Oxidation of thiols in the Ca2+-ATPase of sarcoplasmic reticulum microsomes

1986 • 31 citations

Protein synthesis in hyperoxic endothelial cells: evidence for translational defect

1987 • 30 citations

Ascorbate protects against tert-butyl hydroperoxide inhibition of erythrocyte membrane Ca2+ + Mg2+-ATPase

1990 • 26 citations

Agonist-sensitive calcium pool in the pancreatic acinar cell. I. Permeability properties

1988 • 25 citations

Histamine and bradykinin stimulate the phosphoinositide turnover in human umbilical vein endothelial cells via different G‐proteins

1989 • 25 citations

Carmustine augments the effects of tert-butyl hydroperoxide on calcium signaling in cultured pulmonary artery endothelial cells.

1990 • 24 citations

Oxidative stress inhibits bradykinin-stimulated 45Ca2+ flux in pulmonary vascular endothelial cells

1991 • 21 citations

Mechanism of inhibition of red blood cell glutathione reductase activity by bcnu (1,3-bis(2-chloroethyl)-1-nitrosourea)

1979 • 20 citations

Membrane depolarization inhibits thrombin‐induced calcium influx and aggregation in human platelets

1990 • 12 citations

Endotoxin-induced pulmonary endothelial injury.

1989 • 12 citations

Hyperoxia increases plasminogen activator activity of cultured endothelial cells

1992 • 7 citations

Ion channels in endothelial cells

1998 • 6 citations

Pharmacologic Properties of Isolated Proximal Pulmonary Arteries after Seven-Day Exposure toIn VivoHyperoxia

1988 • 6 citations